Regulon

Regulon: R-2426

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
462.53995192Pr-137Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
25937 ENSG00000018408 WWTR1 Q9GZV5
3309 ENSG00000044574 HSPA5 P11021
841 ENSG00000064012 CASP8 Q14790
6400 ENSG00000071537 SEL1L Q9UBV2
64778 ENSG00000075420 FNDC3B Q53EP0
3385 ENSG00000076662 ICAM3 P32942
334 ENSG00000084234 APLP2 Q06481
966 ENSG00000085063 CD59 P13987
10484 ENSG00000100934 SEC23A Q15436
2184 ENSG00000103876 FAH P16930
5573 ENSG00000108946 PRKAR1A P10644
10312 ENSG00000110719 TCIRG1 Q13488
523 ENSG00000114573 ATP6V1A P38606
4179 ENSG00000117335 CD46 P15529
5311 ENSG00000118762 PKD2 Q13563
2107 ENSG00000120705 ETF1 P62495
6237 ENSG00000126458 RRAS P10301
813 ENSG00000128595 CALU O43852
51303 ENSG00000134285 FKBP11 Q9NYL4
3601 ENSG00000134470 IL15RA K9N1J3
3915 ENSG00000135862 LAMC1 P11047
10097 ENSG00000138071 ACTR2 P61160
4060 ENSG00000139329 LUM P51884
8826 ENSG00000140575 IQGAP1 P46940
1213 ENSG00000141367 CLTC A0A087WVQ6
5899 ENSG00000144118 RALB P11234
56929 ENSG00000145780 FEM1C Q96JP0
3688 ENSG00000150093 ITGB1 P05556
831 ENSG00000153113 CAST P20810
5937 ENSG00000153250 RBMS1 P29558
9320 ENSG00000153827 TRIP12 Q14669
476 ENSG00000163399 ATP1A1 P05023
7534 ENSG00000164924 YWHAZ P63104
840 ENSG00000165806 CASP7 P55210
693215 ENSG00000166233 ARIH1 Q9Y4X5
2720 ENSG00000170266 GLB1 F8WEN1
3308 ENSG00000170606 HSPA4 P34932
6197 ENSG00000177189 RPS6KA3 P51812
25825 ENSG00000182240 BACE2 Q9Y5Z0
302 ENSG00000182718 ANXA2 P07355
307 ENSG00000196975 ANXA4 Q6P452
375035 ENSG00000213064 SFT2D2 O95562
81567 ENSG00000239264 TXNDC5 Q8NBS9
3460 ENSG00000262795 IFNGR2 P38484
123803 ENSG00000275779 NTAN1 H3BNJ5
8754 ENSG00000282230 ADAM9 Q13443

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
ATN-161ITGB3ProteinANTAGONISTIntegrin alpha-5/beta-1 antagonist20
TAS0612RPS6KB1Small moleculeINHIBITORp90RSK inhibitor10
LANATOSIDE CATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
NIVOCASANCASP1Small moleculeINHIBITORCaspase-9 inhibitor20
NATALIZUMABITGA4AntibodyINHIBITORIntegrin alpha-4/beta-1 inhibitor40
FIRATEGRASTITGB1Small moleculeANTAGONISTIntegrin alpha-4/beta-1 antagonist20
EMRICASANCASP4Small moleculeINHIBITORCaspase inhibitor20
DIGOXINATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
ACETYLDIGITOXINATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
OCRIPLASMINLAMA2EnzymePROTEOLYTIC ENZYMEFibronectin proteolytic enzyme40
DIGITOXINATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
VOLOCIXIMABITGB1AntibodyANTAGONISTIntegrin alpha-5/beta-1 antagonist30
RECOMBINANT HUMAN INTERLEUKIN-15IL2RBUnknownAGONISTInterleukin-15 receptor agonist20
DESLANOSIDEATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
ISTAROXIMEATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor20
ABITUZUMABITGAVAntibodyINHIBITORIntegrin alpha-V/beta-5 inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2426

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00651HMCN1up-regulatesIRF3activatesR-24262513Drugs (16)
CMF-00990TPTEup-regulatesIRF3activatesR-2426257Drugs (16)
CMF-06994ATRXdown-regulatesIRF3activatesR-24262517Drugs (16)
CMF-10977BMP5up-regulatesIRF3activatesR-2426257Drugs (16)
CMF-16456SUSD5up-regulatesIRF3activatesR-2426257Drugs (16)
CMF-18707MPP7down-regulatesIRF3activatesR-24262510Drugs (16)
CMF-21525KLHL34down-regulatesIRF3activatesR-2426254Drugs (16)
CMF-22697IDH1down-regulatesIRF3activatesR-24262520Drugs (16)
CMF-23873TP53down-regulatesIRF3activatesR-24262518Drugs (16)
CMF-28087CELSR3down-regulatesIRF3activatesR-2426256Drugs (16)
CMF-28626ARHGAP28down-regulatesIRF3activatesR-2426251Drugs (16)
CMF-30690ABCA13down-regulatesIRF3activatesR-2426258Drugs (16)
CMF-33998MCM6down-regulateshsa-mir-129repressesR-242615576Drugs (16)
CMF-34106TMPRSS15down-regulateshsa-mir-33repressesR-24262925Drugs (16)
CMF-34131TMPRSS15down-regulateshsa-mir-181brepressesR-24263633Drugs (16)
CMF-34170PCDH9up-regulateshsa-mir-181drepressesR-2426316Drugs (16)
CMF-34513JAG2down-regulateshsa-mir-181brepressesR-24263616Drugs (16)
CMF-34601MYH8down-regulateshsa-mir-33repressesR-24262911Drugs (16)
CMF-34618MYH8down-regulateshsa-mir-129repressesR-242615550Drugs (16)
CMF-34664MYH8down-regulateshsa-mir-219repressesR-24264122Drugs (16)
CMF-34684MYH8down-regulateshsa-mir-577repressesR-24266514Drugs (16)
CMF-35293ATRXup-regulateshsa-mir-181drepressesR-24263128Drugs (16)
CMF-35400ATRXup-regulateshsa-mir-219repressesR-24264139Drugs (16)
CMF-35440ATRXup-regulateshsa-mir-181brepressesR-24263636Drugs (16)
CMF-35567ATRXup-regulateshsa-mir-9repressesR-24262525Drugs (16)
CMF-35634ATRXup-regulateshsa-mir-197repressesR-242633Drugs (16)
CMF-35652ATRXup-regulateshsa-mir-577repressesR-24266565Drugs (16)
CMF-35712ATRXup-regulateshsa-mir-20brepressesR-24264435Drugs (16)
CMF-35771NOD2down-regulateshsa-mir-153repressesR-24266232Drugs (16)
CMF-35827NOD2down-regulateshsa-mir-577repressesR-24266547Drugs (16)
CMF-36429TANC2down-regulateshsa-mir-33repressesR-2426291Drugs (16)
CMF-36467RP1up-regulateshsa-mir-181drepressesR-2426314Drugs (16)
CMF-36503CUL1down-regulateshsa-mir-197repressesR-242632Drugs (16)
CMF-36842SEMG1up-regulateshsa-mir-9repressesR-2426255Drugs (16)
CMF-36906LRBAdown-regulateshsa-mir-218repressesR-24261411Drugs (16)
CMF-36932LRBAdown-regulateshsa-mir-181brepressesR-24263627Drugs (16)
CMF-37049NRKdown-regulateshsa-mir-218repressesR-2426149Drugs (16)
CMF-37062NRKdown-regulateshsa-mir-129repressesR-242615531Drugs (16)
CMF-37098NRKdown-regulateshsa-mir-338repressesR-24267926Drugs (16)
CMF-37429HTR3Eup-regulateshsa-mir-218repressesR-2426149Drugs (16)
CMF-37446HTR3Eup-regulateshsa-mir-129repressesR-242615571Drugs (16)
CMF-37528SLC5A4down-regulateshsa-mir-219repressesR-24264120Drugs (16)
CMF-37609SLC26A8down-regulateshsa-mir-490repressesR-24263519Drugs (16)
CMF-37626SLC26A8down-regulateshsa-mir-181brepressesR-24263619Drugs (16)
CMF-37663TUBA3Cdown-regulateshsa-mir-197repressesR-242631Drugs (16)
CMF-38522USP42down-regulateshsa-mir-197repressesR-242631Drugs (16)
CMF-38525USP11up-regulateshsa-mir-20brepressesR-2426444Drugs (16)
CMF-38878TBC1D8down-regulateshsa-mir-20brepressesR-2426441Drugs (16)
CMF-39181LAMA1down-regulateshsa-mir-153repressesR-24266229Drugs (16)
CMF-39232MPP7up-regulateshsa-mir-181brepressesR-24263615Drugs (16)
CMF-39376COL4A4down-regulateshsa-mir-20brepressesR-2426441Drugs (16)
CMF-39459NF1down-regulateshsa-mir-181drepressesR-24263127Drugs (16)
CMF-39503NF1down-regulateshsa-mir-153repressesR-24266228Drugs (16)
CMF-39581NF1down-regulateshsa-mir-95repressesR-24267347Drugs (16)
CMF-39652NF1down-regulateshsa-mir-9repressesR-24262510Drugs (16)
CMF-39719NF1down-regulateshsa-mir-20brepressesR-24264431Drugs (16)
CMF-39985TDRD9down-regulateshsa-mir-197repressesR-242633Drugs (16)
CMF-40019FREM1down-regulateshsa-mir-153repressesR-24266223Drugs (16)
CMF-40048CUX2down-regulateshsa-mir-153repressesR-24266210Drugs (16)
CMF-40076CYP4B1down-regulateshsa-mir-181brepressesR-2426367Drugs (16)
CMF-40148KRTAP4-7down-regulateshsa-mir-33repressesR-24262922Drugs (16)
CMF-40175KRTAP4-7down-regulateshsa-mir-181brepressesR-24263629Drugs (16)
CMF-40407SSTR4down-regulateshsa-mir-33repressesR-2426292Drugs (16)
CMF-40539IDH1up-regulateshsa-mir-181drepressesR-24263130Drugs (16)
CMF-40594IDH1up-regulateshsa-mir-153repressesR-24266262Drugs (16)
CMF-40724IDH1up-regulateshsa-mir-219repressesR-24264141Drugs (16)
CMF-40857IDH1up-regulateshsa-mir-9repressesR-24262525Drugs (16)
CMF-40924IDH1up-regulateshsa-mir-197repressesR-242633Drugs (16)
CMF-40942IDH1up-regulateshsa-mir-577repressesR-24266565Drugs (16)
CMF-41002IDH1up-regulateshsa-mir-20brepressesR-24264435Drugs (16)
CMF-41460TP53up-regulateshsa-mir-197repressesR-242633Drugs (16)
CMF-41478TP53up-regulateshsa-mir-577repressesR-24266563Drugs (16)
CMF-41544TP53up-regulateshsa-mir-20brepressesR-24264444Drugs (16)
CMF-42062KDM2Bdown-regulateshsa-mir-33repressesR-2426291Drugs (16)
CMF-42079CTNNA2down-regulateshsa-mir-218repressesR-2426145Drugs (16)
CMF-42191NAALADL1down-regulateshsa-mir-219repressesR-2426411Drugs (16)
CMF-42192NAALADL1down-regulateshsa-mir-181brepressesR-2426361Drugs (16)
CMF-42193NAALADL1down-regulateshsa-mir-338repressesR-2426795Drugs (16)
CMF-42199C5AR1down-regulateshsa-mir-218repressesR-2426141Drugs (16)
CMF-42201C5AR1down-regulateshsa-mir-490repressesR-2426351Drugs (16)
CMF-42202C5AR1down-regulateshsa-mir-129repressesR-24261556Drugs (16)
CMF-42210C5AR1down-regulateshsa-mir-219repressesR-2426411Drugs (16)
CMF-42320CMYA5up-regulateshsa-mir-577repressesR-24266510Drugs (16)
CMF-42410ANKRD36down-regulateshsa-mir-181drepressesR-2426315Drugs (16)
CMF-42425ANKRD36down-regulateshsa-mir-219repressesR-2426415Drugs (16)
CMF-42431ANKRD36down-regulateshsa-mir-181brepressesR-2426366Drugs (16)
CMF-42445ANKRD36down-regulateshsa-mir-9repressesR-24262511Drugs (16)
CMF-42455ANKRD36down-regulateshsa-mir-338repressesR-2426798Drugs (16)
CMF-42750AQP10up-regulateshsa-mir-129repressesR-242615541Drugs (16)
CMF-42799AQP10up-regulateshsa-mir-338repressesR-24267924Drugs (16)
CMF-42887SEMA3Edown-regulateshsa-mir-218repressesR-24261411Drugs (16)
CMF-42907SEMA3Edown-regulateshsa-mir-129repressesR-242615554Drugs (16)