Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ACTR2 - actin related protein 2
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10097 | ENSG00000138071 | ACTR2 | P61160 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-1463 | Pr-131 | 1 | 1 | 6 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-175 | Pr-0 | 1 | 1 | 11 |
| R-176 | Pr-143 | 1 | 1 | 4 |
| R-177 | Pr-131 | 1 | 1 | 55 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-2145 | Pr-131 | 1 | 1 | 21 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3231 | Pr-131 | 1 | 1 | 53 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-970 | Pr-131 | 1 | 1 | 56 |
| R-995 | Pr-131 | 1 | 1 | 19 |