Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
APLP2 - amyloid beta precursor like protein 2
Function
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 334 | ENSG00000084234 | APLP2 | Q06481 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-1521 | Pr-131 | 1 | 1 | 20 |
| R-160 | Pr-131 | 1 | 1 | 10 |
| R-1699 | Pr-131 | 1 | 1 | 18 |
| R-175 | Pr-0 | 1 | 1 | 11 |
| R-176 | Pr-143 | 1 | 1 | 4 |
| R-177 | Pr-131 | 1 | 1 | 55 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-194 | Pr-131 | 1 | 1 | 5 |
| R-1945 | Pr-131 | 1 | 1 | 9 |
| R-2104 | Pr-131 | 1 | 1 | 23 |
| R-2145 | Pr-131 | 1 | 1 | 21 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2609 | Pr-131 | 1 | 1 | 17 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3449 | Pr-131 | 1 | 1 | 60 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-970 | Pr-131 | 1 | 1 | 56 |
| R-995 | Pr-131 | 1 | 1 | 19 |