Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
BACE2 - beta-secretase 2
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (PubMed:10591213, PubMed:11083922, PubMed:11423558, PubMed:15857888, PubMed:16816112). Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets (PubMed:23754390). Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 25825 | ENSG00000182240 | BACE2 | Q9Y5Z0 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1068 | Pr-0 | 1 | 1 | 4 |
| R-1100 | Pr-0 | 1 | 1 | 8 |
| R-114 | Pr-0 | 1 | 1 | 12 |
| R-1356 | Pr-0 | 1 | 1 | 4 |
| R-1676 | Pr-0 | 1 | 1 | 13 |
| R-1806 | Pr-133 | 1 | 1 | 21 |
| R-209 | Pr-0 | 1 | 1 | 6 |
| R-2348 | Pr-0 | 1 | 1 | 9 |
| R-2358 | Pr-0 | 1 | 1 | 11 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2452 | Pr-0 | 1 | 1 | 3 |
| R-2509 | Pr-0 | 1 | 1 | 9 |
| R-258 | Pr-0 | 1 | 1 | 9 |
| R-2687 | Pr-0 | 1 | 1 | 14 |
| R-3103 | Pr-0 | 1 | 1 | 9 |
| R-3161 | Pr-0 | 1 | 1 | 13 |
| R-375 | Pr-0 | 1 | 1 | 9 |
| R-648 | Pr-0 | 1 | 1 | 7 |
| R-848 | Pr-0 | 1 | 1 | 9 |