Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
HSPA5 - heat shock protein family A (Hsp70) member 5
Function
(Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:24355926, PubMed:20484814, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3309 | ENSG00000044574 | HSPA5 | P11021 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-1463 | Pr-131 | 1 | 1 | 6 |
| R-160 | Pr-131 | 1 | 1 | 10 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-194 | Pr-131 | 1 | 1 | 5 |
| R-2078 | Pr-131 | 1 | 1 | 20 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2798 | Pr-17 | 1 | 1 | 50 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2995 | Pr-131 | 1 | 1 | 4 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3449 | Pr-131 | 1 | 1 | 60 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-970 | Pr-131 | 1 | 1 | 56 |