Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ETF1 - eukaryotic translation termination factor 1
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965, PubMed:24486019). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 2107 | ENSG00000120705 | ETF1 | P62495 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-1521 | Pr-131 | 1 | 1 | 20 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-194 | Pr-131 | 1 | 1 | 5 |
| R-2078 | Pr-131 | 1 | 1 | 20 |
| R-2104 | Pr-131 | 1 | 1 | 23 |
| R-2145 | Pr-131 | 1 | 1 | 21 |
| R-2372 | Pr-131 | 1 | 1 | 7 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2609 | Pr-131 | 1 | 1 | 17 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-2995 | Pr-131 | 1 | 1 | 4 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3036 | Pr-131 | 1 | 1 | 3 |
| R-3231 | Pr-131 | 1 | 1 | 53 |
| R-3449 | Pr-131 | 1 | 1 | 60 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-3481 | Pr-12 | 1 | 1 | 45 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-970 | Pr-131 | 1 | 1 | 56 |