Basic gene annotations are collected from Uniprot
and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser
is available.
FGF9 - fibroblast growth factor 9
Function
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Uniprot BrowserEntrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
---|---|---|---|
2254 | ENSG00000102678 | FGF9 | P31371 |
Causal Flows
are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation
may causally activate or deactivate a downstream regulator
which then might up- down-regulates a regulon
that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000102678 as Regulator
ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
---|---|---|---|---|---|---|---|---|
CMF-00512 | HMCN1 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
CMF-00513 | HMCN1 | down-regulates | FGF9 | represses | R-1770 | 4 | 3 | Drugs (1) |
CMF-00514 | HMCN1 | down-regulates | FGF9 | represses | R-1767 | 4 | 3 | Drugs (2) |
CMF-00938 | TPTE | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
CMF-00939 | TPTE | down-regulates | FGF9 | represses | R-1770 | 4 | 3 | Drugs (1) |
CMF-00940 | TPTE | down-regulates | FGF9 | represses | R-1767 | 4 | 3 | Drugs (2) |
CMF-01246 | RNF168 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-01444 | MTOR | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-01593 | MCM6 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-01784 | TMPRSS15 | down-regulates | FGF9 | represses | R-1770 | 4 | 2 | Drugs (1) |
CMF-01785 | TMPRSS15 | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-02262 | CHD9 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-02287 | ERG | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-03289 | NOTCH2 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-03521 | GRIN2A | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-04179 | RBPJL | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-04652 | DMD | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-05266 | PCSK6 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-05356 | KDELC2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-05442 | KIAA1549 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-05864 | ZNF813 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-06068 | FGFR3 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-06214 | GABRB2 | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-06413 | PODNL1 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-06664 | ATRX | up-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
CMF-06665 | ATRX | up-regulates | FGF9 | represses | R-1770 | 4 | 4 | Drugs (1) |
CMF-06666 | ATRX | up-regulates | FGF9 | represses | R-1767 | 4 | 4 | Drugs (2) |
CMF-07228 | NOD2 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-09591 | OR9G9 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-11187 | NRK | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
CMF-11188 | NRK | down-regulates | FGF9 | represses | R-1770 | 4 | 3 | Drugs (1) |
CMF-11189 | NRK | down-regulates | FGF9 | represses | R-1767 | 4 | 3 | Drugs (2) |
CMF-12119 | COL6A3 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-12379 | MAST4 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-14384 | SLC4A1 | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
CMF-14385 | SLC4A1 | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-14890 | SDHAP3 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-15107 | KCNQ5 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-15534 | TAS2R41 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-15594 | DCHS2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-15715 | FN1 | down-regulates | FGF9 | represses | R-1770 | 4 | 2 | Drugs (1) |
CMF-15716 | FN1 | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-15771 | GRM3 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-16165 | USP11 | up-regulates | FGF9 | represses | R-1770 | 4 | 2 | Drugs (1) |
CMF-16279 | COBLL1 | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
CMF-16280 | COBLL1 | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-16892 | TIE1 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-17365 | TBC1D8 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-17446 | OR5L2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-17493 | PCDH19 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-18329 | DNMBP | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-18426 | LAMA1 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
CMF-18427 | LAMA1 | down-regulates | FGF9 | represses | R-1770 | 4 | 3 | Drugs (1) |
CMF-18428 | LAMA1 | down-regulates | FGF9 | represses | R-1767 | 4 | 3 | Drugs (2) |
CMF-18796 | SLFN13 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-18967 | CLEC14A | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-20532 | ADCY1 | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
CMF-20533 | ADCY1 | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-20933 | KLHL13 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-20973 | KRTAP4-7 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
CMF-20974 | KRTAP4-7 | down-regulates | FGF9 | represses | R-1770 | 4 | 3 | Drugs (1) |
CMF-20975 | KRTAP4-7 | down-regulates | FGF9 | represses | R-1767 | 4 | 3 | Drugs (2) |
CMF-21244 | EGR1 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-21555 | MUC17 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-21875 | PRAME | down-regulates | FGF9 | represses | R-1770 | 4 | 2 | Drugs (1) |
CMF-21876 | PRAME | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-22256 | IDH1 | up-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
CMF-22257 | IDH1 | up-regulates | FGF9 | represses | R-1770 | 4 | 4 | Drugs (1) |
CMF-22258 | IDH1 | up-regulates | FGF9 | represses | R-1767 | 4 | 4 | Drugs (2) |
CMF-23154 | RNF17 | down-regulates | FGF9 | represses | R-1770 | 4 | 3 | Drugs (1) |
CMF-23155 | RNF17 | down-regulates | FGF9 | represses | R-1767 | 4 | 3 | Drugs (2) |
CMF-23557 | TP53 | up-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
CMF-23558 | TP53 | up-regulates | FGF9 | represses | R-1770 | 4 | 4 | Drugs (1) |
CMF-23559 | TP53 | up-regulates | FGF9 | represses | R-1767 | 4 | 4 | Drugs (2) |
CMF-25398 | CENPF | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-25907 | MMP13 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-25978 | CTNNA2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
CMF-26448 | EGFR | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
CMF-26449 | EGFR | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-26618 | C5AR1 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-26681 | FBN2 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-27238 | PDYN | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
CMF-27276 | CHD5 | down-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
CMF-27277 | CHD5 | down-regulates | FGF9 | represses | R-1770 | 4 | 4 | Drugs (1) |
CMF-27278 | CHD5 | down-regulates | FGF9 | represses | R-1767 | 4 | 4 | Drugs (2) |
CMF-27432 | SDK1 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-27566 | ANKRD36 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-28159 | C1S | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-28510 | CALN1 | down-regulates | FGF9 | represses | R-1767 | 4 | 1 | Drugs (2) |
CMF-29146 | AQP10 | up-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
CMF-29147 | AQP10 | up-regulates | FGF9 | represses | R-1770 | 4 | 2 | Drugs (1) |
CMF-29477 | SEMA3E | down-regulates | FGF9 | represses | R-1770 | 4 | 2 | Drugs (1) |
CMF-29478 | SEMA3E | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
CMF-29826 | ABCC9 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
CMF-29827 | ABCC9 | down-regulates | FGF9 | represses | R-1770 | 4 | 3 | Drugs (1) |
CMF-29828 | ABCC9 | down-regulates | FGF9 | represses | R-1767 | 4 | 3 | Drugs (2) |
CMF-30032 | FAM126B | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
CMF-30033 | FAM126B | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |