Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation CTNNA2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-25978 | CTNNA2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-25981 | CTNNA2 | up-regulates | STAT3 | activates | R-1521 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-25982 | CTNNA2 | up-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-25983 | CTNNA2 | up-regulates | NFKB1 | activates | R-297 | 25 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)MIDOSTAURIN, DIPYRIDAMOLE, SOTRASTAURIN, UCN-01, DELCASERTIB, GSK-690693 |
| CMF-25986 | CTNNA2 | down-regulates | FOXD3 | represses | R-576 | 25 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-25990 | CTNNA2 | up-regulates | RORA | activates | R-1945 | 8 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-25996 | CTNNA2 | up-regulates | MAFG | activates | R-1510 | 13 | 4 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-26000 | CTNNA2 | up-regulates | ARID3A | activates | R-679 | 19 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-26006 | CTNNA2 | down-regulates | NEUROD1 | represses | R-3572 | 5 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26017 | CTNNA2 | down-regulates | GBX2 | represses | R-2078 | 7 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-26021 | CTNNA2 | up-regulates | BACH1 | activates | R-2748 | 11 | 2 | Drugs (2) |
| CMF-26022 | CTNNA2 | up-regulates | BACH1 | activates | R-2746 | 11 | 2 | Drugs (3) |
| CMF-42078 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 5 | Drugs (1) |
| CMF-42079 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2426 | 14 | 5 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-42080 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 5 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-42081 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2837 | 14 | 5 | Drugs (1) |
| CMF-42082 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 5 | Drugs (1) |
| CMF-42083 | CTNNA2 | down-regulates | hsa-mir-329 | represses | R-2402 | 6 | 2 | Drugs (1) |
| CMF-42084 | CTNNA2 | down-regulates | hsa-mir-329 | represses | R-2837 | 6 | 2 | Drugs (1) |