Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation COL6A3_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00305 | COL6A3 | up-regulates | IRF9 | activates | R-1457 | 15 | 3 | Drugs (2) |
| CMF-00306 | COL6A3 | up-regulates | IRF9 | activates | R-1446 | 15 | 3 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-00307 | COL6A3 | up-regulates | IRF9 | activates | R-1451 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00309 | COL6A3 | down-regulates | POU3F4 | represses | R-3552 | 10 | 3 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-00312 | COL6A3 | up-regulates | ESRRA | activates | R-1970 | 19 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-00314 | COL6A3 | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00318 | COL6A3 | up-regulates | ARID3A | activates | R-680 | 19 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-00319 | COL6A3 | up-regulates | ARID3A | activates | R-683 | 19 | 4 | Drugs (2) |
| CMF-00321 | COL6A3 | down-regulates | THRA | represses | R-99 | 11 | 3 | Drugs (5) |
| CMF-00324 | COL6A3 | up-regulates | IRF1 | activates | R-123 | 25 | 4 | Drugs (1) |
| CMF-00325 | COL6A3 | up-regulates | IRF1 | activates | R-133 | 25 | 4 | Drugs (42) Regulator Drugs (0)Regulon Drugs (42)EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR |
| CMF-00326 | COL6A3 | up-regulates | TEAD3 | activates | R-2100 | 15 | 3 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-00327 | COL6A3 | up-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-00329 | COL6A3 | up-regulates | JUN | activates | R-222 | 25 | 4 | Drugs (5) |
| CMF-00330 | COL6A3 | up-regulates | JUN | activates | R-231 | 25 | 4 | Drugs (2) |
| CMF-00331 | COL6A3 | up-regulates | JUN | activates | R-224 | 25 | 4 | Drugs (1) |
| CMF-00332 | COL6A3 | up-regulates | JUN | activates | R-211 | 25 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB |
| CMF-00333 | COL6A3 | up-regulates | HLX | represses | R-3585 | 10 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00335 | COL6A3 | up-regulates | HLX | activates | R-3582 | 10 | 3 | Drugs (4) |
| CMF-00338 | COL6A3 | down-regulates | SOX5 | represses | R-274 | 18 | 3 | Drugs (2) |
| CMF-00343 | COL6A3 | up-regulates | FOSL1 | activates | R-1988 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00344 | COL6A3 | down-regulates | POU6F1 | represses | R-3377 | 8 | 3 | Drugs (2) |
| CMF-00346 | COL6A3 | down-regulates | POU6F1 | represses | R-3379 | 8 | 3 | Drugs (2) |
| CMF-00347 | COL6A3 | up-regulates | HMGA2 | activates | R-3603 | 2 | 1 | Drugs (3) |
| CMF-00348 | COL6A3 | down-regulates | PBX1 | represses | R-3161 | 12 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-00350 | COL6A3 | down-regulates | PBX1 | represses | R-3166 | 12 | 3 | Drugs (4) |
| CMF-00357 | COL6A3 | up-regulates | NFATC4 | activates | R-2712 | 10 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00358 | COL6A3 | up-regulates | NFATC4 | activates | R-2705 | 10 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-00359 | COL6A3 | up-regulates | NFATC4 | activates | R-2710 | 10 | 4 | Drugs (1) |
| CMF-00360 | COL6A3 | up-regulates | STAT6 | activates | R-2279 | 11 | 2 | Drugs (2) |
| CMF-00361 | COL6A3 | up-regulates | STAT6 | activates | R-2280 | 11 | 2 | Drugs (2) |
| CMF-00363 | COL6A3 | up-regulates | PLAG1 | activates | R-2509 | 5 | 4 | Drugs (2) |
| CMF-00364 | COL6A3 | up-regulates | PLAG1 | activates | R-2508 | 5 | 4 | Drugs (4) |
| CMF-00365 | COL6A3 | up-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-00366 | COL6A3 | up-regulates | PLAG1 | activates | R-2510 | 5 | 4 | Drugs (5) |
| CMF-12119 | COL6A3 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-12127 | COL6A3 | up-regulates | RFX2 | activates | R-2298 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12129 | COL6A3 | down-regulates | TEF | represses | R-2656 | 15 | 1 | Drugs (4) |