Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation KLHL13_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-20933 | KLHL13 | down-regulates | FGF9 | represses | R-1770 | 4 | 1 | Drugs (1) |
| CMF-20934 | KLHL13 | up-regulates | ARID5B | activates | R-3008 | 4 | 1 | Drugs (1) |
| CMF-20935 | KLHL13 | up-regulates | NFKB1 | activates | R-307 | 25 | 2 | Drugs (2) |
| CMF-20936 | KLHL13 | up-regulates | NFKB1 | activates | R-299 | 25 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-20938 | KLHL13 | down-regulates | FOXD3 | represses | R-576 | 25 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20940 | KLHL13 | down-regulates | FOXD3 | represses | R-578 | 25 | 6 | Drugs (5) |
| CMF-20945 | KLHL13 | up-regulates | ELF1 | activates | R-334 | 24 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-20947 | KLHL13 | down-regulates | SOX10 | represses | R-3069 | 8 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20948 | KLHL13 | down-regulates | POU4F1 | represses | R-2758 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20951 | KLHL13 | up-regulates | IRF1 | activates | R-118 | 25 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-20953 | KLHL13 | down-regulates | HOXB13 | represses | R-3231 | 15 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20955 | KLHL13 | down-regulates | HOXB13 | represses | R-3240 | 15 | 3 | Drugs (2) |
| CMF-20956 | KLHL13 | down-regulates | POU4F2 | represses | R-2783 | 13 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20961 | KLHL13 | up-regulates | BACH1 | activates | R-2749 | 11 | 2 | Drugs (5) |
| CMF-20962 | KLHL13 | up-regulates | BACH1 | activates | R-2746 | 11 | 2 | Drugs (3) |
| CMF-20963 | KLHL13 | down-regulates | DLX2 | represses | R-3576 | 4 | 1 | Drugs (4) |