Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation GABRB2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-06214 | GABRB2 | down-regulates | FGF9 | represses | R-1767 | 4 | 2 | Drugs (2) |
| CMF-06220 | GABRB2 | down-regulates | POU4F1 | activates | R-2757 | 11 | 1 | Drugs (2) |
| CMF-06223 | GABRB2 | up-regulates | NFE2L2 | activates | R-1379 | 10 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06224 | GABRB2 | down-regulates | TCF3 | activates | R-1600 | 18 | 3 | Drugs (2) |
| CMF-06231 | GABRB2 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-06235 | GABRB2 | down-regulates | HLF | activates | R-3311 | 5 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-35133 | GABRB2 | up-regulates | hsa-mir-30e-3p | represses | R-2679 | 11 | 5 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |
| CMF-35134 | GABRB2 | up-regulates | hsa-mir-30e-3p | represses | R-1734 | 11 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-35135 | GABRB2 | up-regulates | hsa-mir-30e-3p | represses | R-3789 | 11 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-35136 | GABRB2 | up-regulates | hsa-mir-30e-3p | represses | R-2008 | 11 | 5 | Drugs (1) |
| CMF-35137 | GABRB2 | up-regulates | hsa-mir-30e-3p | represses | R-2043 | 11 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |