Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

MAFB - MAF bZIP transcription factor B

Function

Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
9935	ENSG00000204103	MAFB	Q9Y5Q3

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000204103 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00738	DNAH5	up-regulates	MAFB	activates	R-1902	25	2	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-00739	DNAH5	up-regulates	MAFB	activates	R-1917	25	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01047	ZNF292	down-regulates	MAFB	activates	R-1912	25	10	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-01048	ZNF292	down-regulates	MAFB	activates	R-1901	25	10	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-01049	ZNF292	down-regulates	MAFB	activates	R-1902	25	10	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-01050	ZNF292	down-regulates	MAFB	activates	R-1900	25	10	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, MIVACURIUM, EPELSIBAN, ROCURONIUM BROMIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, CARBETOCIN, TISOTUMAB VEDOTIN, NOLASIBAN, VANTICTUMAB, ATOSIBAN, FE 202767, BARUSIBAN, ROCURONIUM, RETOSIBAN, DAVALINTIDE
CMF-01051	ZNF292	down-regulates	MAFB	activates	R-1921	25	10	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) BRICICLIB, PALBOCICLIB
CMF-01053	ZNF292	down-regulates	MAFB	activates	R-1903	25	10	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-01055	ZNF292	down-regulates	MAFB	activates	R-1904	25	10	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-01168	SKAP2	up-regulates	MAFB	activates	R-1902	25	2	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-01600	MCM6	up-regulates	MAFB	activates	R-1912	25	7	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-01601	MCM6	up-regulates	MAFB	activates	R-1901	25	7	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-01602	MCM6	up-regulates	MAFB	activates	R-1905	25	7	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-01603	MCM6	up-regulates	MAFB	activates	R-1902	25	7	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-01604	MCM6	up-regulates	MAFB	activates	R-1911	25	7	Drugs (23) Regulator Drugs (0) Regulon Drugs (23) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-01605	MCM6	up-regulates	MAFB	activates	R-1903	25	7	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-01778	TMEM146	up-regulates	MAFB	activates	R-1909	25	1	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-02682	SLC9A10	down-regulates	MAFB	activates	R-1912	25	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-02684	SLC9A10	down-regulates	MAFB	activates	R-1902	25	3	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-05199	ZFYVE26	down-regulates	MAFB	activates	R-1900	25	6	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, MIVACURIUM, EPELSIBAN, ROCURONIUM BROMIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, CARBETOCIN, TISOTUMAB VEDOTIN, NOLASIBAN, VANTICTUMAB, ATOSIBAN, FE 202767, BARUSIBAN, ROCURONIUM, RETOSIBAN, DAVALINTIDE
CMF-05202	ZFYVE26	down-regulates	MAFB	activates	R-1904	25	6	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-06322	MATN4	down-regulates	MAFB	activates	R-1921	25	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) BRICICLIB, PALBOCICLIB
CMF-07969	OR5D13	up-regulates	MAFB	activates	R-1900	25	2	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, MIVACURIUM, EPELSIBAN, ROCURONIUM BROMIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, CARBETOCIN, TISOTUMAB VEDOTIN, NOLASIBAN, VANTICTUMAB, ATOSIBAN, FE 202767, BARUSIBAN, ROCURONIUM, RETOSIBAN, DAVALINTIDE
CMF-07970	OR5D13	up-regulates	MAFB	activates	R-1906	25	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-08023	ATP10B	up-regulates	MAFB	activates	R-1916	25	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-08103	PLEKHG4B	down-regulates	MAFB	activates	R-1907	25	4	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-09601	OR9G9	up-regulates	MAFB	activates	R-1900	25	6	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, MIVACURIUM, EPELSIBAN, ROCURONIUM BROMIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, CARBETOCIN, TISOTUMAB VEDOTIN, NOLASIBAN, VANTICTUMAB, ATOSIBAN, FE 202767, BARUSIBAN, ROCURONIUM, RETOSIBAN, DAVALINTIDE
CMF-09602	OR9G9	up-regulates	MAFB	activates	R-1911	25	6	Drugs (23) Regulator Drugs (0) Regulon Drugs (23) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-09603	OR9G9	up-regulates	MAFB	activates	R-1914	25	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOMIVOSERTIB
CMF-09605	OR9G9	up-regulates	MAFB	activates	R-1917	25	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10018	ATP8A2	down-regulates	MAFB	activates	R-1905	25	10	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-10021	ATP8A2	down-regulates	MAFB	activates	R-1902	25	10	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-10023	ATP8A2	down-regulates	MAFB	activates	R-1911	25	10	Drugs (23) Regulator Drugs (0) Regulon Drugs (23) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-10024	ATP8A2	down-regulates	MAFB	activates	R-1903	25	10	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-10025	ATP8A2	down-regulates	MAFB	activates	R-1907	25	10	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-10877	SMARCA2	up-regulates	MAFB	activates	R-1902	25	3	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-10878	SMARCA2	up-regulates	MAFB	activates	R-1906	25	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-11398	CYP4F22	up-regulates	MAFB	activates	R-1905	25	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-11400	CYP4F22	up-regulates	MAFB	activates	R-1902	25	6	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-11401	CYP4F22	up-regulates	MAFB	activates	R-1906	25	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-11402	CYP4F22	up-regulates	MAFB	activates	R-1909	25	6	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-11403	CYP4F22	up-regulates	MAFB	activates	R-1916	25	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-11908	SPAM1	down-regulates	MAFB	activates	R-1909	25	1	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-12229	GPR98	down-regulates	MAFB	activates	R-1912	25	13	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-12230	GPR98	down-regulates	MAFB	activates	R-1901	25	13	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-12231	GPR98	down-regulates	MAFB	activates	R-1905	25	13	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-12233	GPR98	down-regulates	MAFB	activates	R-1921	25	13	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) BRICICLIB, PALBOCICLIB
CMF-12236	GPR98	down-regulates	MAFB	activates	R-1911	25	13	Drugs (23) Regulator Drugs (0) Regulon Drugs (23) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-12237	GPR98	down-regulates	MAFB	activates	R-1903	25	13	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-12238	GPR98	down-regulates	MAFB	activates	R-1914	25	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOMIVOSERTIB
CMF-12239	GPR98	down-regulates	MAFB	activates	R-1907	25	13	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-12770	NTN4	down-regulates	MAFB	activates	R-1907	25	2	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-13973	CDKN2C	up-regulates	MAFB	activates	R-1905	25	2	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-13974	CDKN2C	up-regulates	MAFB	activates	R-1907	25	2	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-14608	C1orf177	up-regulates	MAFB	activates	R-1902	25	1	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-15047	PTEN	up-regulates	MAFB	activates	R-1917	25	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16017	NFIX	up-regulates	MAFB	activates	R-1902	25	9	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-16018	NFIX	up-regulates	MAFB	activates	R-1900	25	9	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, MIVACURIUM, EPELSIBAN, ROCURONIUM BROMIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, CARBETOCIN, TISOTUMAB VEDOTIN, NOLASIBAN, VANTICTUMAB, ATOSIBAN, FE 202767, BARUSIBAN, ROCURONIUM, RETOSIBAN, DAVALINTIDE
CMF-16019	NFIX	up-regulates	MAFB	activates	R-1906	25	9	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-16020	NFIX	up-regulates	MAFB	activates	R-1907	25	9	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-16022	NFIX	up-regulates	MAFB	activates	R-1909	25	9	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-17899	CYLC2	down-regulates	MAFB	activates	R-1921	25	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) BRICICLIB, PALBOCICLIB
CMF-17935	PRPF40B	down-regulates	MAFB	activates	R-1912	25	10	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-17936	PRPF40B	down-regulates	MAFB	activates	R-1905	25	10	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-17938	PRPF40B	down-regulates	MAFB	activates	R-1902	25	10	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-17940	PRPF40B	down-regulates	MAFB	activates	R-1911	25	10	Drugs (23) Regulator Drugs (0) Regulon Drugs (23) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-17941	PRPF40B	down-regulates	MAFB	activates	R-1903	25	10	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-17942	PRPF40B	down-regulates	MAFB	activates	R-1907	25	10	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-19631	RPSAP58	up-regulates	MAFB	activates	R-1901	25	8	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-19632	RPSAP58	up-regulates	MAFB	activates	R-1905	25	8	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-19634	RPSAP58	up-regulates	MAFB	activates	R-1902	25	8	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-19637	RPSAP58	up-regulates	MAFB	activates	R-1903	25	8	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-19638	RPSAP58	up-regulates	MAFB	activates	R-1907	25	8	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-19688	UGT2B4	up-regulates	MAFB	activates	R-1905	25	4	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-19690	UGT2B4	up-regulates	MAFB	activates	R-1902	25	4	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-19963	ANO4	up-regulates	MAFB	activates	R-1904	25	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-20102	TDRD9	up-regulates	MAFB	activates	R-1902	25	7	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-20104	TDRD9	up-regulates	MAFB	activates	R-1906	25	7	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-20105	TDRD9	up-regulates	MAFB	activates	R-1909	25	7	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-20106	TDRD9	up-regulates	MAFB	activates	R-1904	25	7	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-20107	TDRD9	up-regulates	MAFB	activates	R-1916	25	7	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-20563	ADCY1	up-regulates	MAFB	activates	R-1901	25	6	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-20565	ADCY1	up-regulates	MAFB	activates	R-1900	25	6	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, MIVACURIUM, EPELSIBAN, ROCURONIUM BROMIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, CARBETOCIN, TISOTUMAB VEDOTIN, NOLASIBAN, VANTICTUMAB, ATOSIBAN, FE 202767, BARUSIBAN, ROCURONIUM, RETOSIBAN, DAVALINTIDE
CMF-20567	ADCY1	up-regulates	MAFB	activates	R-1904	25	6	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-21160	ADAM30	up-regulates	MAFB	activates	R-1914	25	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOMIVOSERTIB
CMF-21506	KLHL34	down-regulates	MAFB	activates	R-1901	25	4	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-21507	KLHL34	down-regulates	MAFB	activates	R-1905	25	4	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-21508	KLHL34	down-regulates	MAFB	activates	R-1903	25	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-21509	KLHL34	down-regulates	MAFB	activates	R-1916	25	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-21585	MUC17	up-regulates	MAFB	activates	R-1912	25	11	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-21586	MUC17	up-regulates	MAFB	activates	R-1901	25	11	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-21587	MUC17	up-regulates	MAFB	activates	R-1905	25	11	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-21589	MUC17	up-regulates	MAFB	activates	R-1902	25	11	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-21590	MUC17	up-regulates	MAFB	activates	R-1903	25	11	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-21591	MUC17	up-regulates	MAFB	activates	R-1907	25	11	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-21592	MUC17	up-regulates	MAFB	activates	R-1909	25	11	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-21594	MUC17	up-regulates	MAFB	activates	R-1904	25	11	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-24304	SMCHD1	up-regulates	MAFB	activates	R-1902	25	6	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-24305	SMCHD1	up-regulates	MAFB	activates	R-1914	25	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOMIVOSERTIB
CMF-24306	SMCHD1	up-regulates	MAFB	activates	R-1906	25	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-24307	SMCHD1	up-regulates	MAFB	activates	R-1909	25	6	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-24309	SMCHD1	up-regulates	MAFB	activates	R-1916	25	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-24845	NSUN5	down-regulates	MAFB	activates	R-1912	25	5	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-24846	NSUN5	down-regulates	MAFB	activates	R-1905	25	5	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-24848	NSUN5	down-regulates	MAFB	activates	R-1902	25	5	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-24849	NSUN5	down-regulates	MAFB	activates	R-1907	25	5	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-25815	CD163	down-regulates	MAFB	activates	R-1914	25	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOMIVOSERTIB
CMF-25816	CD163	down-regulates	MAFB	activates	R-1909	25	2	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-26077	MST1P9	down-regulates	MAFB	activates	R-1907	25	1	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-27203	HTR3A	up-regulates	MAFB	activates	R-1914	25	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOMIVOSERTIB
CMF-27289	CHD5	up-regulates	MAFB	activates	R-1902	25	8	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-27290	CHD5	up-regulates	MAFB	activates	R-1900	25	8	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, MIVACURIUM, EPELSIBAN, ROCURONIUM BROMIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, CARBETOCIN, TISOTUMAB VEDOTIN, NOLASIBAN, VANTICTUMAB, ATOSIBAN, FE 202767, BARUSIBAN, ROCURONIUM, RETOSIBAN, DAVALINTIDE
CMF-27291	CHD5	up-regulates	MAFB	activates	R-1903	25	8	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-27292	CHD5	up-regulates	MAFB	activates	R-1906	25	8	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-27294	CHD5	up-regulates	MAFB	activates	R-1904	25	8	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-27575	ANKRD36	up-regulates	MAFB	activates	R-1901	25	10	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-27576	ANKRD36	up-regulates	MAFB	activates	R-1905	25	10	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-27578	ANKRD36	up-regulates	MAFB	activates	R-1902	25	10	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-27580	ANKRD36	up-regulates	MAFB	activates	R-1911	25	10	Drugs (23) Regulator Drugs (0) Regulon Drugs (23) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-27581	ANKRD36	up-regulates	MAFB	activates	R-1907	25	10	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-27582	ANKRD36	up-regulates	MAFB	activates	R-1904	25	10	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-29388	PTCHD3	down-regulates	MAFB	activates	R-1907	25	4	Drugs (15) Regulator Drugs (0) Regulon Drugs (15) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB
CMF-29389	PTCHD3	down-regulates	MAFB	activates	R-1904	25	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB
CMF-30507	JHDM1D	down-regulates	MAFB	activates	R-1902	25	6	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON
CMF-30510	JHDM1D	down-regulates	MAFB	activates	R-1916	25	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-30568	C17orf71	up-regulates	MAFB	activates	R-1912	25	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-30569	C17orf71	up-regulates	MAFB	activates	R-1901	25	4	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-31089	LRFN2	down-regulates	MAFB	activates	R-1902	25	4	Drugs (29) Regulator Drugs (0) Regulon Drugs (29) FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, HYDROXYCHLOROQUINE, R-343, AME-133V, R-348, CERDULATINIB, VESATOLIMOD, AZD-8848, EFALIZUMAB, HMPL-523, HYDROXYCHLOROQUINE SULFATE, PETESICATIB, ENTOSPLETINIB, CPG-52852, R-333, IMIQUIMOD, IC14, GUSACITINIB, LIFITEGRAST, VB-201, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON

MAFB - MAF bZIP transcription factor B

Function

Causal Mechanistic Flows with ENSG00000204103 as Regulator

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