Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation MST1P9_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-26052 | MST1P9 | down-regulates | POU2F2 | represses | R-1740 | 14 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)MK-8777, PERAMPANEL, PF-04958242, TEZAMPANEL, SELURAMPANEL, TALAMPANEL, FARAMPATOR, ZONAMPANEL, TAK-653, TOPIRAMATE, MIBAMPATOR |
| CMF-26055 | MST1P9 | up-regulates | TRIM28 | activates | R-763 | 7 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)RO-6870810, MOLIBRESIB, BIRABRESIB, BMS-986158, CPI-0610, APABETALONE |
| CMF-26058 | MST1P9 | up-regulates | SATB1 | activates | R-1694 | 24 | 6 | Drugs (1) |
| CMF-26077 | MST1P9 | down-regulates | MAFB | activates | R-1907 | 25 | 1 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB |
| CMF-26094 | MST1P9 | down-regulates | STAT4 | represses | R-1147 | 16 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26096 | MST1P9 | up-regulates | TBP | activates | R-3460 | 18 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)RIMEGEPANT SULFATE, TELCAGEPANT, ATOGEPANT, UBROGEPANT, ERENUMAB, 2X-121, RIMEGEPANT, BI-44370, MK3207, DAVALINTIDE, OLCEGEPANT |
| CMF-26111 | MST1P9 | up-regulates | FOXJ3 | activates | R-1162 | 23 | 5 | Drugs (2) |
| CMF-26115 | MST1P9 | up-regulates | FOXJ3 | activates | R-1167 | 23 | 5 | Drugs (2) |
| CMF-26121 | MST1P9 | up-regulates | GTF2I | represses | R-3483 | 7 | 3 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, CARFILZOMIB |
| CMF-26126 | MST1P9 | up-regulates | CEBPZ | represses | R-2999 | 12 | 3 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)MIRDAMETINIB, BINIMETINIB, COBIMETINIB FUMARATE, RO-4987655, COBIMETINIB, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, E-6201, TRAMETINIB, REFAMETINIB, CI-1040, TRAMETINIB DIMETHYL SULFOXIDE, TAK-733, AS-703988 |
| CMF-26151 | MST1P9 | up-regulates | TCF3 | activates | R-1600 | 18 | 3 | Drugs (2) |
| CMF-42101 | MST1P9 | up-regulates | hsa-mir-301 | represses | R-183 | 37 | 4 | Drugs (4) |
| CMF-42102 | MST1P9 | up-regulates | hsa-mir-301 | represses | R-2836 | 37 | 4 | Drugs (4) |
| CMF-42103 | MST1P9 | up-regulates | hsa-mir-301 | represses | R-896 | 37 | 4 | Drugs (4) |
| CMF-42104 | MST1P9 | up-regulates | hsa-mir-301 | represses | R-1613 | 37 | 4 | Drugs (4) |