Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation LRFN2_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-31063LRFN2up-regulatesPOU3F3repressesR-2632193Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BERMEKIMAB, LUTIKIZUMAB, EMRICASAN

CMF-31065LRFN2down-regulatesCDX1activatesR-312673Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-31069LRFN2up-regulatesGTF2IRD1repressesR-318622Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

OPROZOMIB, IXAZOMIB, MARIZOMIB, BORTEZOMIB, IXAZOMIB CITRATE, CARFILZOMIB

CMF-31072LRFN2up-regulatesNR2F1repressesR-2767155Drugs (16)
CMF-31074LRFN2up-regulatesNR2F1repressesR-2778155Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-31084LRFN2up-regulatesFOXO1activatesR-701214Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

MRTX-849, SOTORASIB

CMF-31089LRFN2down-regulatesMAFBactivatesR-1902254Drugs (29)
CMF-31091LRFN2down-regulatesSREBF1activatesR-2507122Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

TOSEDOSTAT

CMF-31092LRFN2down-regulatesSREBF1activatesR-2500122Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-31105LRFN2down-regulatesSPI1activatesR-383255Drugs (12)
CMF-31108LRFN2down-regulatesSPI1activatesR-370255Drugs (199)

Regulator Drugs (0)

Regulon Drugs (199)

PF-04691502, LY-2787106, FOSTAMATINIB DISODIUM, PICOTAMIDE, SARGRAMOSTIM, UMBRALISIB, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, BGT-226, SONOLISIB, RUPATADINE, CSL-324, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, BMS-986142, HM-71224, SUNITINIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, PEXIDARTINIB HYDROCHLORIDE, PF-06651600, AMY-101, LIPEGFILGRASTIM, ABIVERTINIB, VRC-01LS, PAZOPANIB HYDROCHLORIDE, ABIVERTINIB MALEATE, VICRIVIROC, MEDI-2338, VATALANIB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, CAROTUXIMAB, L19TNFA, EDICOTINIB, APLAVIROC, MARAVIROC, AZD-8848, SUNITINIB MALATE, EFALIZUMAB, DACTOLISIB, BOSUTINIB, BAFETINIB, FILGRASTIM, ZANDELISIB, HMPL-523, PLX-7486, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, RILZABRUTINIB, BALUGRASTIM, SPEBRUTINIB, SOTRASTAURIN, PILARALISIB, ILORASERTIB, DAPANSUTRILE, ENMD-2076, RO-5458640, CCX354, PREXIGEBERSEN, AMG-820, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, IBRUTINIB, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, PLX-5622, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, ENTOLIMOD, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, AZD4818, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, EVOBRUTINIB, CPG-52852, R-333, IMIQUIMOD, IC14, OTLERTUZUMAB, GUSACITINIB, BI-836826, TOLIMIDONE, MAVRILIMUMAB, TREGALIZUMAB, ERITORAN TETRASODIUM, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, SPEBRUTINIB BESYLATE, PEGCETACOPLAN, VICRIVIROC MALEATE, LENOGRASTIM, POSELTINIB, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, ACALISIB, PF-232798, ZANOLIMUMAB, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, PIRTOBRUTINIB, TELRATOLIMOD, AZD5672, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, FOSTAMATINIB, ELSUBRUTINIB, IMC-CS4, BRANEBRUTINIB, LENIOLISIB, OZAGREL, PA-799, ARRY-382, EMACTUZUMAB, LINTUZUMAB, TIRABRUTINIB, DELCASERTIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, GSK-690693, SF-1126, ORELABRUTINIB, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AL-78898A, ENMD-981693, PANULISIB, AXATILIMAB

CMF-31109LRFN2down-regulatesSPI1activatesR-371255Drugs (31)
CMF-31119LRFN2down-regulatesTAL1activatesR-315113Drugs (158)

Regulator Drugs (0)

Regulon Drugs (158)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, PAZOPANIB, MIDOSTAURIN, ATN-161, BGT-226, SONOLISIB, RUPATADINE, CSL-324, TERBOGREL, PARSACLISIB, ONERCEPT, R-343, VOXTALISIB, SUNITINIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, DASATINIB, DS-7423, GSK-2269557, ABATACEPT, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, PEXIDARTINIB HYDROCHLORIDE, LIPEGFILGRASTIM, PEGSUNERCEPT, PAZOPANIB HYDROCHLORIDE, GOLIMUMAB, VICRIVIROC, VATALANIB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, EDICOTINIB, APLAVIROC, MARAVIROC, SUNITINIB MALATE, DACTOLISIB, FILGRASTIM, ZANDELISIB, HMPL-523, PLX-7486, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, BALUGRASTIM, AFELIMOMAB, SOTRASTAURIN, OZORALIZUMAB, PILARALISIB, ILORASERTIB, CERTOLIZUMAB PEGOL, ENMD-2076, RO-5458640, MUPARFOSTAT, CCX354, PREXIGEBERSEN, AMG-820, TASELISIB, L19SIP 131I, AMG-319, UCN-01, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, PLX-5622, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, GEMTUZUMAB, ENTOLIMOD, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, AZD4818, BELATACEPT, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, R-333, OTLERTUZUMAB, GUSACITINIB, REMTOLUMAB, BI-836826, ERITORAN TETRASODIUM, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, VICRIVIROC MALEATE, LENOGRASTIM, PEXIDARTINIB, QUIZARTINIB, DUPILUMAB, ACALISIB, PF-232798, MIVAVOTINIB CITRATE, BMS-817399, AZD5672, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, FOSTAMATINIB, IMC-CS4, LENIOLISIB, OZAGREL, PA-799, ARRY-382, EMACTUZUMAB, PLACULUMAB, LINTUZUMAB, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, GSK-690693, SF-1126, CABIRALIZUMAB, ENMD-981693, PANULISIB, AXATILIMAB, NELFINAVIR

CMF-31124LRFN2up-regulatesBCL6activatesR-627235Drugs (11)
CMF-31134LRFN2down-regulatesSTAT5AactivatesR-2943215Drugs (16)
CMF-31138LRFN2up-regulatesGTF2IrepressesR-348372Drugs (11)
CMF-31146LRFN2up-regulatesPARP1activatesR-2374112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-31149LRFN2down-regulatesSPIBactivatesR-362942Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BERMEKIMAB, LUTIKIZUMAB, EMRICASAN

CMF-31154LRFN2up-regulatesTCF3activatesR-1600187Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-31155LRFN2up-regulatesTCF3repressesR-1592187Drugs (17)
CMF-31161LRFN2up-regulatesFOXJ2activatesR-723174Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-31169LRFN2down-regulatesVDRactivatesR-232145Drugs (60)
CMF-31177LRFN2up-regulatesTCF4repressesR-1608176Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

EMRICASAN

CMF-31178LRFN2up-regulatesTCF4repressesR-1613176Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG

CMF-31183LRFN2down-regulatesIRF8activatesR-410184Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-31185LRFN2down-regulatesIRF8activatesR-397184Drugs (16)
CMF-31186LRFN2down-regulatesIRF8activatesR-395184Drugs (75)
CMF-31192LRFN2down-regulatesSTAT6activatesR-2287113Drugs (6)
CMF-31196LRFN2up-regulatesTCF7L1repressesR-44994Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BRENSOCATIB

CMF-31199LRFN2up-regulatesTCF7L1repressesR-44494Drugs (66)
CMF-43333LRFN2up-regulateshsa-mir-423repressesR-18333Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG

CMF-43334LRFN2up-regulateshsa-mir-423repressesR-283633Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG

CMF-43335LRFN2up-regulateshsa-mir-423repressesR-161333Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG

CMF-43336LRFN2up-regulateshsa-mir-30brepressesR-19294Drugs (56)
CMF-43337LRFN2up-regulateshsa-mir-30brepressesR-23294Drugs (60)
CMF-43338LRFN2up-regulateshsa-mir-30brepressesR-27594Drugs (29)
CMF-43339LRFN2up-regulateshsa-mir-30brepressesR-35094Drugs (20)