Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

LHX3 - LIM homeobox 3

Function

Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (PubMed:21149718). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity).

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
8022	ENSG00000107187	LHX3	Q9UBR4

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000107187 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00975	TPTE	down-regulates	LHX3	represses	R-2002	24	9	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-00976	TPTE	down-regulates	LHX3	represses	R-2006	24	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-00977	TPTE	down-regulates	LHX3	represses	R-2011	24	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-00979	TPTE	down-regulates	LHX3	represses	R-2005	24	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-00981	TPTE	down-regulates	LHX3	represses	R-1994	24	9	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-00982	TPTE	down-regulates	LHX3	represses	R-1997	24	9	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-01182	SKAP2	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-01183	SKAP2	down-regulates	LHX3	represses	R-2008	24	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-01185	SKAP2	down-regulates	LHX3	represses	R-1997	24	4	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-01474	MTOR	down-regulates	LHX3	represses	R-2002	24	8	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-01475	MTOR	down-regulates	LHX3	represses	R-2006	24	8	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-01476	MTOR	down-regulates	LHX3	represses	R-2011	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01480	MTOR	down-regulates	LHX3	represses	R-1996	24	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-01481	MTOR	down-regulates	LHX3	represses	R-1994	24	8	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-01617	MCM6	down-regulates	LHX3	represses	R-1995	24	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-01618	MCM6	down-regulates	LHX3	represses	R-2008	24	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-01619	MCM6	down-regulates	LHX3	represses	R-2005	24	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-01621	MCM6	down-regulates	LHX3	represses	R-2007	24	6	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-02711	ABCA5	down-regulates	LHX3	represses	R-2006	24	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-04140	KIAA2026	down-regulates	LHX3	represses	R-1995	24	1	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-04235	RBPJL	down-regulates	LHX3	represses	R-2011	24	11	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04236	RBPJL	down-regulates	LHX3	represses	R-2015	24	11	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04238	RBPJL	down-regulates	LHX3	represses	R-1999	24	11	Drugs (84) Regulator Drugs (0) Regulon Drugs (84) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-04242	RBPJL	down-regulates	LHX3	represses	R-2007	24	11	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-04243	RBPJL	down-regulates	LHX3	represses	R-1997	24	11	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-04756	ADAMTS20	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-04759	ADAMTS20	down-regulates	LHX3	represses	R-1996	24	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-05457	KIAA1549	down-regulates	LHX3	represses	R-2011	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05460	KIAA1549	down-regulates	LHX3	represses	R-1994	24	4	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-05641	ITGB7	down-regulates	LHX3	represses	R-1994	24	2	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-06609	CACNA1D	down-regulates	LHX3	represses	R-2006	24	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-07287	NOD2	down-regulates	LHX3	represses	R-2006	24	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-07288	NOD2	down-regulates	LHX3	represses	R-1995	24	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-07289	NOD2	down-regulates	LHX3	represses	R-2011	24	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07290	NOD2	down-regulates	LHX3	represses	R-2005	24	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-07291	NOD2	down-regulates	LHX3	represses	R-1996	24	9	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-07292	NOD2	down-regulates	LHX3	represses	R-2007	24	9	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-07293	NOD2	down-regulates	LHX3	represses	R-1994	24	9	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-07294	NOD2	down-regulates	LHX3	represses	R-1997	24	9	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-07415	THOC2	down-regulates	LHX3	represses	R-2002	24	8	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07416	THOC2	down-regulates	LHX3	represses	R-2011	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07417	THOC2	down-regulates	LHX3	represses	R-2016	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07420	THOC2	down-regulates	LHX3	represses	R-1996	24	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-07421	THOC2	down-regulates	LHX3	represses	R-2007	24	8	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-07422	THOC2	down-regulates	LHX3	represses	R-1994	24	8	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-07662	DPPA4	down-regulates	LHX3	represses	R-2007	24	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-08415	ADCY2	down-regulates	LHX3	represses	R-2008	24	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-08435	COL17A1	down-regulates	LHX3	represses	R-2006	24	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-08436	COL17A1	down-regulates	LHX3	represses	R-2016	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08438	COL17A1	down-regulates	LHX3	represses	R-1996	24	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-09376	CUL1	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-09377	CUL1	down-regulates	LHX3	represses	R-2005	24	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-09427	ZIC4	down-regulates	LHX3	represses	R-1996	24	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-09428	ZIC4	down-regulates	LHX3	represses	R-1994	24	2	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-10773	LMO7	down-regulates	LHX3	represses	R-1996	24	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-11345	KCNT1	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11587	FNDC3B	down-regulates	LHX3	represses	R-2002	24	1	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-11874	PALM2-AKAP2	down-regulates	LHX3	represses	R-2002	24	5	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-11875	PALM2-AKAP2	down-regulates	LHX3	represses	R-1995	24	5	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-11876	PALM2-AKAP2	down-regulates	LHX3	represses	R-2011	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11878	PALM2-AKAP2	down-regulates	LHX3	represses	R-1994	24	5	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-11922	SPAM1	down-regulates	LHX3	represses	R-1996	24	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-12672	WDFY3	down-regulates	LHX3	represses	R-2015	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13185	SLC26A8	down-regulates	LHX3	represses	R-2005	24	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-13458	FMN1	down-regulates	LHX3	represses	R-2008	24	7	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-13459	FMN1	down-regulates	LHX3	represses	R-2011	24	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13461	FMN1	down-regulates	LHX3	represses	R-1996	24	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-13462	FMN1	down-regulates	LHX3	represses	R-1997	24	7	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-13798	ADAMTS8	up-regulates	LHX3	represses	R-2006	24	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-13799	ADAMTS8	up-regulates	LHX3	represses	R-1995	24	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-13801	ADAMTS8	up-regulates	LHX3	represses	R-2011	24	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13802	ADAMTS8	up-regulates	LHX3	represses	R-2016	24	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13803	ADAMTS8	up-regulates	LHX3	represses	R-1999	24	9	Drugs (84) Regulator Drugs (0) Regulon Drugs (84) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-13805	ADAMTS8	up-regulates	LHX3	represses	R-2005	24	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-14142	CD1D	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-14143	CD1D	down-regulates	LHX3	represses	R-1994	24	2	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-14201	ZNF516	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-14204	ZNF516	down-regulates	LHX3	represses	R-1994	24	4	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-14396	LYPLA2P1	down-regulates	LHX3	represses	R-1994	24	1	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-15111	KCNQ5	down-regulates	LHX3	represses	R-2011	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15112	KCNQ5	down-regulates	LHX3	represses	R-1994	24	4	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-15283	HCN1	down-regulates	LHX3	represses	R-2006	24	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-15284	HCN1	down-regulates	LHX3	represses	R-2011	24	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15542	TAS2R41	down-regulates	LHX3	represses	R-2005	24	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-15543	TAS2R41	down-regulates	LHX3	represses	R-1994	24	4	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-15544	TAS2R41	down-regulates	LHX3	represses	R-1997	24	4	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-15656	DCHS2	down-regulates	LHX3	represses	R-2002	24	5	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-15657	DCHS2	down-regulates	LHX3	represses	R-2011	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15658	DCHS2	down-regulates	LHX3	represses	R-1999	24	5	Drugs (84) Regulator Drugs (0) Regulon Drugs (84) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-15659	DCHS2	down-regulates	LHX3	represses	R-2007	24	5	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-15660	DCHS2	down-regulates	LHX3	represses	R-1994	24	5	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-15731	FN1	down-regulates	LHX3	represses	R-1994	24	2	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-15828	ZNF358	down-regulates	LHX3	represses	R-1995	24	1	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-16123	USP42	down-regulates	LHX3	represses	R-1997	24	1	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-16433	SUSD5	down-regulates	LHX3	represses	R-2006	24	7	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-16436	SUSD5	down-regulates	LHX3	represses	R-1996	24	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-16437	SUSD5	down-regulates	LHX3	represses	R-1994	24	7	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-16702	SI	down-regulates	LHX3	represses	R-2005	24	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-17389	TBC1D8	down-regulates	LHX3	represses	R-1994	24	4	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-17499	PCDH19	down-regulates	LHX3	represses	R-1996	24	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-17831	CSF2RB	down-regulates	LHX3	represses	R-2002	24	1	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-18138	SGIP1	down-regulates	LHX3	represses	R-2011	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18139	SGIP1	down-regulates	LHX3	represses	R-2015	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18140	SGIP1	down-regulates	LHX3	represses	R-2007	24	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-18297	MEGF8	down-regulates	LHX3	represses	R-1995	24	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-18298	MEGF8	down-regulates	LHX3	represses	R-2007	24	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-18470	LAMA1	down-regulates	LHX3	represses	R-2002	24	8	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-18471	LAMA1	down-regulates	LHX3	represses	R-2006	24	8	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-18472	LAMA1	down-regulates	LHX3	represses	R-2011	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18474	LAMA1	down-regulates	LHX3	represses	R-2005	24	8	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-18475	LAMA1	down-regulates	LHX3	represses	R-1996	24	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-18477	LAMA1	down-regulates	LHX3	represses	R-1994	24	8	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-19075	COL4A4	down-regulates	LHX3	represses	R-2006	24	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-19930	ACTL9	down-regulates	LHX3	represses	R-2006	24	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-19931	ACTL9	down-regulates	LHX3	represses	R-2016	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19932	ACTL9	down-regulates	LHX3	represses	R-1996	24	5	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-19933	ACTL9	down-regulates	LHX3	represses	R-1994	24	5	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-20184	PARP4	down-regulates	LHX3	represses	R-1994	24	1	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-20219	GPR15	down-regulates	LHX3	represses	R-2008	24	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-20220	GPR15	down-regulates	LHX3	represses	R-2011	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20222	GPR15	down-regulates	LHX3	represses	R-2007	24	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-20581	ADCY1	down-regulates	LHX3	represses	R-2011	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20582	ADCY1	down-regulates	LHX3	represses	R-2015	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20583	ADCY1	down-regulates	LHX3	represses	R-2007	24	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-20668	CYP4B1	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-20669	CYP4B1	down-regulates	LHX3	represses	R-2011	24	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20722	ALPK1	down-regulates	LHX3	represses	R-2006	24	3	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-20723	ALPK1	down-regulates	LHX3	represses	R-2011	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20749	DSG4	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20881	CLOCK	down-regulates	LHX3	represses	R-2008	24	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-21259	EGR1	down-regulates	LHX3	represses	R-2007	24	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-21951	FAT1	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-21953	FAT1	down-regulates	LHX3	represses	R-1996	24	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-21954	FAT1	down-regulates	LHX3	represses	R-1994	24	4	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-22569	IDH1	up-regulates	LHX3	represses	R-2002	24	21	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-22570	IDH1	up-regulates	LHX3	represses	R-2006	24	21	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-22571	IDH1	up-regulates	LHX3	represses	R-1995	24	21	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-22573	IDH1	up-regulates	LHX3	represses	R-2008	24	21	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-22574	IDH1	up-regulates	LHX3	represses	R-2011	24	21	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22575	IDH1	up-regulates	LHX3	represses	R-2015	24	21	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22576	IDH1	up-regulates	LHX3	represses	R-2016	24	21	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22577	IDH1	up-regulates	LHX3	represses	R-1999	24	21	Drugs (84) Regulator Drugs (0) Regulon Drugs (84) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-22578	IDH1	up-regulates	LHX3	represses	R-2005	24	21	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-22582	IDH1	up-regulates	LHX3	represses	R-1996	24	21	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-22583	IDH1	up-regulates	LHX3	represses	R-2007	24	21	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-22585	IDH1	up-regulates	LHX3	represses	R-1994	24	21	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-22586	IDH1	up-regulates	LHX3	represses	R-1997	24	21	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-24267	SIM1	down-regulates	LHX3	represses	R-2011	24	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24794	HIST1H2BE	down-regulates	LHX3	represses	R-2002	24	6	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-24795	HIST1H2BE	down-regulates	LHX3	represses	R-2006	24	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-24797	HIST1H2BE	down-regulates	LHX3	represses	R-2008	24	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-24891	ELMO1	down-regulates	LHX3	represses	R-2008	24	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-24958	NLRP1	down-regulates	LHX3	represses	R-2002	24	3	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-24959	NLRP1	down-regulates	LHX3	represses	R-2008	24	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-25141	FLT3	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-25142	FLT3	down-regulates	LHX3	represses	R-2016	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-25144	FLT3	down-regulates	LHX3	represses	R-2005	24	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-25648	SVOPL	down-regulates	LHX3	represses	R-1996	24	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-26587	NAALADL1	down-regulates	LHX3	represses	R-2016	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26588	NAALADL1	down-regulates	LHX3	represses	R-1999	24	3	Drugs (84) Regulator Drugs (0) Regulon Drugs (84) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-27323	CHD5	down-regulates	LHX3	represses	R-2011	24	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27327	CHD5	down-regulates	LHX3	represses	R-1994	24	6	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-27515	KRTAP20-2	down-regulates	LHX3	represses	R-1999	24	3	Drugs (84) Regulator Drugs (0) Regulon Drugs (84) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-27516	KRTAP20-2	down-regulates	LHX3	represses	R-1997	24	3	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-27618	ANKRD36	down-regulates	LHX3	represses	R-1995	24	5	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-27619	ANKRD36	down-regulates	LHX3	represses	R-2011	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27620	ANKRD36	down-regulates	LHX3	represses	R-1999	24	5	Drugs (84) Regulator Drugs (0) Regulon Drugs (84) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-27622	ANKRD36	down-regulates	LHX3	represses	R-2007	24	5	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-28214	REPIN1	down-regulates	LHX3	represses	R-2011	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28216	REPIN1	down-regulates	LHX3	represses	R-2007	24	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-28259	ZIC1	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-28260	ZIC1	down-regulates	LHX3	represses	R-2006	24	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-28261	ZIC1	down-regulates	LHX3	represses	R-1996	24	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-28716	TSHZ2	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28947	NPHS1	down-regulates	LHX3	represses	R-2002	24	3	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-29068	DNAH3	down-regulates	LHX3	represses	R-1996	24	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-29093	TUBB4Q	down-regulates	LHX3	represses	R-2002	24	1	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-29495	SEMA3E	down-regulates	LHX3	represses	R-2006	24	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-29496	SEMA3E	down-regulates	LHX3	represses	R-2016	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29497	SEMA3E	down-regulates	LHX3	represses	R-2005	24	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-29498	SEMA3E	down-regulates	LHX3	represses	R-1997	24	5	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-30020	MORC1	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30261	RAB3GAP2	down-regulates	LHX3	represses	R-2007	24	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-30580	C17orf71	down-regulates	LHX3	represses	R-2005	24	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB
CMF-30582	C17orf71	down-regulates	LHX3	represses	R-1997	24	4	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-30725	CDC42BPB	down-regulates	LHX3	represses	R-2008	24	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-30808	RYR1	down-regulates	LHX3	represses	R-2006	24	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-30810	RYR1	down-regulates	LHX3	represses	R-1996	24	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-30811	RYR1	down-regulates	LHX3	represses	R-1994	24	6	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-30812	RYR1	down-regulates	LHX3	represses	R-1997	24	6	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-30871	ARMC4	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB

LHX3 - LIM homeobox 3

Function

Causal Mechanistic Flows with ENSG00000107187 as Regulator

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Regulon Drugs (22)