Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation ZIC1_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-28250ZIC1down-regulatesIRF9activatesR-1446152Drugs (12)
CMF-28251ZIC1up-regulatesTEAD1activatesR-2399151Drugs (11)
CMF-28254ZIC1down-regulatesELF5repressesR-3359162Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-28258ZIC1down-regulatesSTAT4repressesR-1144162Drugs (92)

Regulator Drugs (0)

Regulon Drugs (92)

PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, OLECLUMAB, HYDROXYZINE, LORATADINE, LY2624803, BELZUTIFAN, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, OCRIPLASMIN, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

CMF-28259ZIC1down-regulatesLHX3repressesR-2002244Drugs (19)
CMF-28260ZIC1down-regulatesLHX3repressesR-2006244Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-28261ZIC1down-regulatesLHX3repressesR-1996244Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

IMSIDOLIMAB, SPESOLIMAB

CMF-28263ZIC1down-regulatesPAX7repressesR-369731Drugs (7)

Regulator Drugs (0)

Regulon Drugs (7)

AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB

CMF-28268ZIC1down-regulatesCEBPAactivatesR-2605212Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NI-0801, ELDELUMAB

CMF-28272ZIC1up-regulatesSOX11activatesR-851191Drugs (11)
CMF-28274ZIC1down-regulatesELF3repressesR-3683141Drugs (20)
CMF-28281ZIC1down-regulatesHBP1activatesR-1931122Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ZIMLOVISERTIB

CMF-42583ZIC1down-regulateshsa-mir-105repressesR-245181Drugs (14)
CMF-42584ZIC1up-regulateshsa-mir-10brepressesR-189145Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-42585ZIC1up-regulateshsa-mir-10brepressesR-274145Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NI-0801, ELDELUMAB

CMF-42586ZIC1up-regulateshsa-mir-10brepressesR-411145Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NI-0801, ELDELUMAB

CMF-42587ZIC1up-regulateshsa-mir-10brepressesR-2605145Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NI-0801, ELDELUMAB

CMF-42588ZIC1up-regulateshsa-mir-10brepressesR-1847145Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NI-0801, ELDELUMAB

CMF-42589ZIC1down-regulateshsa-mir-338repressesR-21457926Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN

CMF-42590ZIC1down-regulateshsa-mir-338repressesR-1777926Drugs (7)
CMF-42591ZIC1down-regulateshsa-mir-338repressesR-2187926Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-42592ZIC1down-regulateshsa-mir-338repressesR-24517926Drugs (14)
CMF-42593ZIC1down-regulateshsa-mir-338repressesR-24597926Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-42594ZIC1down-regulateshsa-mir-338repressesR-4157926Drugs (8)
CMF-42595ZIC1down-regulateshsa-mir-338repressesR-26227926Drugs (8)
CMF-42596ZIC1down-regulateshsa-mir-338repressesR-6557926Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-42597ZIC1down-regulateshsa-mir-338repressesR-27107926Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN

CMF-42598ZIC1down-regulateshsa-mir-338repressesR-6797926Drugs (8)
CMF-42599ZIC1down-regulateshsa-mir-338repressesR-27607926Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-42600ZIC1down-regulateshsa-mir-338repressesR-7387926Drugs (8)
CMF-42601ZIC1down-regulateshsa-mir-338repressesR-27987926Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-42602ZIC1down-regulateshsa-mir-338repressesR-28927926Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-42603ZIC1down-regulateshsa-mir-338repressesR-30137926Drugs (8)
CMF-42604ZIC1down-regulateshsa-mir-338repressesR-9707926Drugs (8)
CMF-42605ZIC1down-regulateshsa-mir-338repressesR-30727926Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-42606ZIC1down-regulateshsa-mir-338repressesR-34497926Drugs (8)
CMF-42607ZIC1down-regulateshsa-mir-338repressesR-36437926Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-42608ZIC1down-regulateshsa-mir-338repressesR-16457926Drugs (8)
CMF-42609ZIC1down-regulateshsa-mir-338repressesR-20067926Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB