Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ALX4 - ALX homeobox 4
Function
Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 60529 | ENSG00000052850 | ALX4 | Q9H161 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000052850 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00269 | SPTA1 | up-regulates | ALX4 | represses | R-2911 | 20 | 5 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)RIMEGEPANT SULFATE, TELCAGEPANT, ATOGEPANT, UBROGEPANT, ERENUMAB, 2X-121, RIMEGEPANT, BI-44370, MK3207, DAVALINTIDE, OLCEGEPANT |
| CMF-00270 | SPTA1 | up-regulates | ALX4 | represses | R-2908 | 20 | 5 | Drugs (3) |
| CMF-01079 | ZNF292 | up-regulates | ALX4 | represses | R-2924 | 20 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01081 | ZNF292 | up-regulates | ALX4 | represses | R-2926 | 20 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01607 | MCM6 | down-regulates | ALX4 | represses | R-2926 | 20 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02078 | FOXA1 | down-regulates | ALX4 | represses | R-2911 | 20 | 1 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)RIMEGEPANT SULFATE, TELCAGEPANT, ATOGEPANT, UBROGEPANT, ERENUMAB, 2X-121, RIMEGEPANT, BI-44370, MK3207, DAVALINTIDE, OLCEGEPANT |
| CMF-03215 | PTPRM | down-regulates | ALX4 | represses | R-2922 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05972 | SIRPG | down-regulates | ALX4 | represses | R-2914 | 20 | 3 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-06556 | STAG2 | down-regulates | ALX4 | represses | R-2926 | 20 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09121 | NLRP3 | down-regulates | ALX4 | represses | R-2922 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09412 | ZIC4 | down-regulates | ALX4 | represses | R-2908 | 20 | 3 | Drugs (3) |
| CMF-09413 | ZIC4 | down-regulates | ALX4 | represses | R-2922 | 20 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10400 | ZAN | down-regulates | ALX4 | represses | R-2922 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10619 | ITIH5L | down-regulates | ALX4 | represses | R-2909 | 20 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11835 | SKIV2L | down-regulates | ALX4 | represses | R-2914 | 20 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-12116 | PCDH7 | down-regulates | ALX4 | represses | R-2914 | 20 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-14094 | DENND2A | down-regulates | ALX4 | represses | R-2914 | 20 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-14186 | ZNF516 | down-regulates | ALX4 | represses | R-2914 | 20 | 2 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-15011 | TG | down-regulates | ALX4 | represses | R-2914 | 20 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-15315 | GRM8 | down-regulates | ALX4 | represses | R-2914 | 20 | 2 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-15316 | GRM8 | down-regulates | ALX4 | represses | R-2908 | 20 | 2 | Drugs (3) |
| CMF-17375 | TBC1D8 | down-regulates | ALX4 | represses | R-2909 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18979 | MLLT4 | down-regulates | ALX4 | represses | R-2914 | 20 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-19916 | ACTL9 | down-regulates | ALX4 | represses | R-2908 | 20 | 3 | Drugs (3) |
| CMF-20571 | ADCY1 | down-regulates | ALX4 | represses | R-2926 | 20 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20659 | CYP4B1 | down-regulates | ALX4 | represses | R-2914 | 20 | 3 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-20661 | CYP4B1 | down-regulates | ALX4 | represses | R-2926 | 20 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21598 | MUC17 | down-regulates | ALX4 | represses | R-2926 | 20 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21941 | FAT1 | down-regulates | ALX4 | represses | R-2914 | 20 | 3 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-21942 | FAT1 | down-regulates | ALX4 | represses | R-2908 | 20 | 3 | Drugs (3) |
| CMF-21943 | FAT1 | down-regulates | ALX4 | represses | R-2922 | 20 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22025 | WNT2 | down-regulates | ALX4 | represses | R-2914 | 20 | 2 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-23186 | RNF17 | down-regulates | ALX4 | represses | R-2914 | 20 | 7 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-23190 | RNF17 | down-regulates | ALX4 | represses | R-2908 | 20 | 7 | Drugs (3) |
| CMF-23191 | RNF17 | down-regulates | ALX4 | represses | R-2922 | 20 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24321 | SMCHD1 | down-regulates | ALX4 | represses | R-2922 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25402 | CENPF | down-regulates | ALX4 | represses | R-2914 | 20 | 2 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-26306 | CHGB | down-regulates | ALX4 | represses | R-2922 | 20 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26839 | VAV1 | down-regulates | ALX4 | represses | R-2908 | 20 | 3 | Drugs (3) |
| CMF-27302 | CHD5 | down-regulates | ALX4 | represses | R-2922 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27446 | SDK1 | down-regulates | ALX4 | represses | R-2926 | 20 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28713 | TSHZ2 | down-regulates | ALX4 | represses | R-2924 | 20 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29344 | RPL13AP6 | down-regulates | ALX4 | represses | R-2914 | 20 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-30790 | RYR1 | down-regulates | ALX4 | represses | R-2908 | 20 | 3 | Drugs (3) |