Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation TG_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-14992TGup-regulatesTEAD1activatesR-2399151Drugs (11)
CMF-14994TGup-regulatesMTF1activatesR-983235Drugs (16)
CMF-15009TGup-regulatesBPTFrepressesR-2879214Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-15011TGdown-regulatesALX4repressesR-2914201Drugs (19)
CMF-15015TGdown-regulatesLMX1BrepressesR-2927114Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-15017TGdown-regulatesIRF7activatesR-2489212Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NI-0801, ELDELUMAB

CMF-15018TGdown-regulatesIRF7activatesR-2476212Drugs (12)
CMF-15020TGup-regulatesSOX9activatesR-1234162Drugs (16)
CMF-15021TGup-regulatesSOX9activatesR-1225162Drugs (9)
CMF-15027TGdown-regulatesTLX2repressesR-1571256Drugs (18)
CMF-15031TGdown-regulatesTLX2repressesR-1568256Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE

CMF-15032TGdown-regulatesSPIBactivatesR-362941Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BERMEKIMAB, LUTIKIZUMAB, EMRICASAN

CMF-15036TGup-regulatesFOXO3repressesR-748244Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-15041TGdown-regulatesELF3repressesR-3683143Drugs (20)
CMF-15042TGdown-regulatesELF3activatesR-3695143Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NI-0801, ELDELUMAB