Program

Program Pr-25

Genes (25)

MGST2, SLC2A9, TRIM38, PPARG, P2RX4, POLD4, PRR13, HEXA, HLA-DRB1, IGF1, ATP8B4, ACSL1, MERTK, FMNL1, GIMAP5, HERPUD1, ITGA4, MBD4, PTPN7, MYD88, ATG7, HTATIP2, VNN1, DOK1, CRTAP

Regulons (10)

R-133, R-156, R-289, R-690, R-1443, R-2012, R-2595, R-2728, R-2856, R-3503

Regulons in program Pr-25

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-133	2.0947	8	15
R-156	2.18451	6	6
R-289	2.52035	5	15
R-690	1.63432	6	8
R-1443	2.20598	9	6
R-2012	1.91034	6	9
R-2595	1.87814	13	22
R-2728	2.38301	6	2
R-2856	2.22285	6	8
R-3503	1.97337	6	3

Genes in program Pr-25

EnsEMBL Id	Entrez Id	Preferred
ENSG00000085871	4258	MGST2
ENSG00000109667	56606	SLC2A9
ENSG00000112343	10475	TRIM38
ENSG00000132170	5468	PPARG
ENSG00000135124	5025	P2RX4
ENSG00000175482	57804	POLD4
ENSG00000205352	54458	PRR13
ENSG00000213614	3073	HEXA
ENSG00000236884	3123	HLA-DRB1
ENSG00000017427	3479	IGF1
ENSG00000104043	79895	ATP8B4
ENSG00000151726	2180	ACSL1
ENSG00000153208	10461	MERTK
ENSG00000184922	752	FMNL1
ENSG00000196329	55340	GIMAP5
ENSG00000051108	9709	HERPUD1
ENSG00000115232	3676	ITGA4
ENSG00000129071	8930	MBD4
ENSG00000143851	5778	PTPN7
ENSG00000172936	4615	MYD88
ENSG00000197548	10533	ATG7
ENSG00000109854	10553	HTATIP2
ENSG00000112299	8876	VNN1
ENSG00000115325	1796	DOK1
ENSG00000170275	10491	CRTAP

Causal Mechanistic Flows with Program Pr-25

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00325	COL6A3	up-regulates	IRF1	activates	R-133	25	4	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-01674	MMRN1	up-regulates	MAX	activates	R-3503	18	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ABRILUMAB, NATALIZUMAB, FIRATEGRAST, VEDOLIZUMAB
CMF-03493	SLC4A10	down-regulates	POU2F1	represses	R-1443	19	1	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-04222	RBPJL	up-regulates	IRF1	activates	R-133	25	10	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-06853	ATRX	down-regulates	IRF1	activates	R-133	25	13	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-08011	OR5D13	down-regulates	POU2F1	represses	R-1443	19	2	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-09197	TANC2	up-regulates	IRF1	activates	R-133	25	6	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-09216	TANC2	up-regulates	PRDM1	activates	R-156	21	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TROXACITABINE, CLOFARABINE, CYTARABINE, GEMCITABINE HYDROCHLORIDE, GEMCITABINE, ASPACYTARABINE, FLUDARABINE PHOSPHATE
CMF-12912	KCNS2	down-regulates	POU2F1	represses	R-1443	19	1	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-14462	ANKRD33	up-regulates	IRF1	activates	R-133	25	4	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-14501	PRKCD	down-regulates	MAX	activates	R-3503	18	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ABRILUMAB, NATALIZUMAB, FIRATEGRAST, VEDOLIZUMAB
CMF-14771	SLC5A12	down-regulates	POU2F1	represses	R-1443	19	1	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-18876	INPP5J	down-regulates	IRF1	activates	R-133	25	6	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-19495	NF1	up-regulates	PRDM1	activates	R-156	21	16	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TROXACITABINE, CLOFARABINE, CYTARABINE, GEMCITABINE HYDROCHLORIDE, GEMCITABINE, ASPACYTARABINE, FLUDARABINE PHOSPHATE
CMF-19826	OR6C75	up-regulates	MAX	activates	R-3503	18	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ABRILUMAB, NATALIZUMAB, FIRATEGRAST, VEDOLIZUMAB
CMF-21646	MUC17	up-regulates	IRF1	activates	R-133	25	12	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-22499	IDH1	down-regulates	IRF1	activates	R-133	25	14	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-22765	IDH1	down-regulates	PRDM1	activates	R-156	21	18	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TROXACITABINE, CLOFARABINE, CYTARABINE, GEMCITABINE HYDROCHLORIDE, GEMCITABINE, ASPACYTARABINE, FLUDARABINE PHOSPHATE
CMF-22964	IDH1	up-regulates	POU2F1	represses	R-1443	19	11	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-23755	TP53	down-regulates	IRF1	activates	R-133	25	14	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-24097	TP53	up-regulates	POU2F1	represses	R-1443	19	11	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-24944	NLRP1	up-regulates	IRF1	activates	R-133	25	10	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-25030	IQSEC3	down-regulates	IRF1	activates	R-133	25	6	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-25754	INPP5D	down-regulates	IRF1	activates	R-133	25	5	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-26272	CEP250	down-regulates	PRDM1	activates	R-156	21	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TROXACITABINE, CLOFARABINE, CYTARABINE, GEMCITABINE HYDROCHLORIDE, GEMCITABINE, ASPACYTARABINE, FLUDARABINE PHOSPHATE
CMF-27317	CHD5	up-regulates	IRF1	activates	R-133	25	7	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-27682	FAM83H	down-regulates	IRF1	activates	R-133	25	5	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-28097	CELSR3	down-regulates	PRDM1	activates	R-156	21	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TROXACITABINE, CLOFARABINE, CYTARABINE, GEMCITABINE HYDROCHLORIDE, GEMCITABINE, ASPACYTARABINE, FLUDARABINE PHOSPHATE
CMF-28480	OR4A47	down-regulates	IRF1	activates	R-133	25	1	Drugs (42) Regulator Drugs (0) Regulon Drugs (42) EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR
CMF-30700	ABCA13	down-regulates	PRDM1	activates	R-156	21	9	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TROXACITABINE, CLOFARABINE, CYTARABINE, GEMCITABINE HYDROCHLORIDE, GEMCITABINE, ASPACYTARABINE, FLUDARABINE PHOSPHATE

Pr-25

Program Pr-25

Genes (25)

Regulons (10)

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Genes in program Pr-25

Causal Mechanistic Flows with Program Pr-25

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