Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TRIM38 - tripartite motif containing 38
Function
E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470). Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10475 | ENSG00000112343 | TRIM38 | O00635 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1289 | Pr-15 | 1 | 1 | 4 |
| R-133 | Pr-25 | 1 | 1 | 15 |
| R-1443 | Pr-25 | 1 | 1 | 6 |
| R-146 | Pr-15 | 1 | 1 | 16 |
| R-156 | Pr-25 | 1 | 1 | 6 |
| R-165 | Pr-15 | 1 | 1 | 10 |
| R-1728 | Pr-15 | 1 | 1 | 9 |
| R-180 | Pr-15 | 1 | 1 | 6 |
| R-1970 | Pr-15 | 1 | 1 | 10 |
| R-2039 | Pr-15 | 1 | 1 | 2 |
| R-2101 | Pr-15 | 1 | 1 | 10 |
| R-222 | Pr-15 | 1 | 1 | 10 |
| R-2541 | Pr-15 | 1 | 1 | 3 |
| R-2805 | Pr-15 | 1 | 1 | 4 |
| R-3137 | Pr-15 | 1 | 1 | 16 |
| R-3293 | Pr-15 | 1 | 1 | 6 |
| R-3582 | Pr-15 | 1 | 1 | 12 |
| R-3776 | Pr-15 | 1 | 1 | 3 |
| R-405 | Pr-15 | 1 | 1 | 2 |