Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation OR4A47_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-28480 | OR4A47 | down-regulates | IRF1 | activates | R-133 | 25 | 1 | Drugs (42) Regulator Drugs (0)Regulon Drugs (42)EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR |
| CMF-28481 | OR4A47 | down-regulates | ELF4 | activates | R-3028 | 20 | 1 | Drugs (2) |
| CMF-42672 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-171 | 14 | 11 | Drugs (2) |
| CMF-42673 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 11 | Drugs (2) |
| CMF-42674 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 11 | Drugs (2) |
| CMF-42675 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 11 | Drugs (2) |
| CMF-42676 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 11 | Drugs (2) |
| CMF-42677 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 11 | Drugs (2) |
| CMF-42678 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 11 | Drugs (2) |
| CMF-42679 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42680 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 11 | Drugs (2) |
| CMF-42681 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 11 | Drugs (2) |
| CMF-42682 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 11 | Drugs (2) |