Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation HFM1_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02973 | HFM1 | down-regulates | ZNF263 | activates | R-557 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02975 | HFM1 | down-regulates | HOXA3 | represses | R-1466 | 22 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02978 | HFM1 | down-regulates | POU4F1 | represses | R-2760 | 11 | 1 | Drugs (3) |
| CMF-02979 | HFM1 | down-regulates | FEV | represses | R-3033 | 5 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02980 | HFM1 | down-regulates | SIX6 | represses | R-3174 | 4 | 1 | Drugs (3) |
| CMF-02982 | HFM1 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-02983 | HFM1 | down-regulates | HOXB8 | represses | R-1699 | 7 | 2 | Drugs (28) Regulator Drugs (0)Regulon Drugs (28)RUXOLITINIB, PACRITINIB, LONAFARNIB, IZENCITINIB, TOFACITINIB, GANDOTINIB, RUXOLITINIB PHOSPHATE, PEFICITINIB, FORIGERIMOD, TIPIFARNIB, LESTAURTINIB, AC-430, MOMELOTINIB, NS-018, BARICITINIB, BMS-911543, UPADACITINIB, FEDRATINIB HYDROCHLORIDE, ZOTIRACICLIB, TOFACITINIB CITRATE, FORIGERIMOD ACETATE, GUSACITINIB, XL-019, AZD-1480, DELGOCITINIB, OCRIPLASMIN, AT-9283, FEDRATINIB |
| CMF-02984 | HFM1 | down-regulates | NKX6-1 | represses | R-2841 | 20 | 1 | Drugs (2) |
| CMF-34354 | HFM1 | down-regulates | hsa-mir-105 | represses | R-2451 | 8 | 2 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-34355 | HFM1 | down-regulates | hsa-mir-105 | represses | R-3033 | 8 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34356 | HFM1 | down-regulates | hsa-mir-375 | represses | R-218 | 61 | 5 | Drugs (3) |
| CMF-34357 | HFM1 | down-regulates | hsa-mir-375 | represses | R-2459 | 61 | 5 | Drugs (3) |
| CMF-34358 | HFM1 | down-regulates | hsa-mir-375 | represses | R-655 | 61 | 5 | Drugs (3) |
| CMF-34359 | HFM1 | down-regulates | hsa-mir-375 | represses | R-2710 | 61 | 5 | Drugs (1) |
| CMF-34360 | HFM1 | down-regulates | hsa-mir-375 | represses | R-2892 | 61 | 5 | Drugs (3) |