Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
hsa-mir-105 -
Function
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| - | hsa-mir-105 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with hsa-mir-105 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-33887 | SKAP2 | down-regulates | hsa-mir-105 | represses | R-2431 | 8 | 3 | Drugs (2) |
| CMF-33888 | SKAP2 | down-regulates | hsa-mir-105 | represses | R-2830 | 8 | 3 | Drugs (2) |
| CMF-33889 | SKAP2 | down-regulates | hsa-mir-105 | represses | R-3180 | 8 | 3 | Drugs (1) |
| CMF-34160 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-61 | 8 | 8 | Drugs (1) |
| CMF-34161 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-2431 | 8 | 8 | Drugs (2) |
| CMF-34162 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-2451 | 8 | 8 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-34163 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-651 | 8 | 8 | Drugs (2) |
| CMF-34164 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-2830 | 8 | 8 | Drugs (2) |
| CMF-34165 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-2864 | 8 | 8 | Drugs (2) |
| CMF-34166 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-3033 | 8 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34167 | TMPRSS15 | down-regulates | hsa-mir-105 | represses | R-3180 | 8 | 8 | Drugs (1) |
| CMF-34354 | HFM1 | down-regulates | hsa-mir-105 | represses | R-2451 | 8 | 2 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-34355 | HFM1 | down-regulates | hsa-mir-105 | represses | R-3033 | 8 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37092 | NRK | down-regulates | hsa-mir-105 | represses | R-2451 | 8 | 2 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-37093 | NRK | down-regulates | hsa-mir-105 | represses | R-3180 | 8 | 2 | Drugs (1) |
| CMF-38305 | GRM3 | down-regulates | hsa-mir-105 | represses | R-61 | 8 | 7 | Drugs (1) |
| CMF-38306 | GRM3 | down-regulates | hsa-mir-105 | represses | R-2431 | 8 | 7 | Drugs (2) |
| CMF-38307 | GRM3 | down-regulates | hsa-mir-105 | represses | R-651 | 8 | 7 | Drugs (2) |
| CMF-38308 | GRM3 | down-regulates | hsa-mir-105 | represses | R-2830 | 8 | 7 | Drugs (2) |
| CMF-38309 | GRM3 | down-regulates | hsa-mir-105 | represses | R-2864 | 8 | 7 | Drugs (2) |
| CMF-38310 | GRM3 | down-regulates | hsa-mir-105 | represses | R-3033 | 8 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38311 | GRM3 | down-regulates | hsa-mir-105 | represses | R-3180 | 8 | 7 | Drugs (1) |
| CMF-40000 | GPR15 | down-regulates | hsa-mir-105 | represses | R-2431 | 8 | 2 | Drugs (2) |
| CMF-40001 | GPR15 | down-regulates | hsa-mir-105 | represses | R-3033 | 8 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-40096 | ALPK1 | down-regulates | hsa-mir-105 | represses | R-2431 | 8 | 3 | Drugs (2) |
| CMF-40097 | ALPK1 | down-regulates | hsa-mir-105 | represses | R-651 | 8 | 3 | Drugs (2) |
| CMF-40098 | ALPK1 | down-regulates | hsa-mir-105 | represses | R-2830 | 8 | 3 | Drugs (2) |
| CMF-40277 | EGR1 | down-regulates | hsa-mir-105 | represses | R-61 | 8 | 5 | Drugs (1) |
| CMF-40278 | EGR1 | down-regulates | hsa-mir-105 | represses | R-651 | 8 | 5 | Drugs (2) |
| CMF-40279 | EGR1 | down-regulates | hsa-mir-105 | represses | R-2830 | 8 | 5 | Drugs (2) |
| CMF-40280 | EGR1 | down-regulates | hsa-mir-105 | represses | R-2864 | 8 | 5 | Drugs (2) |
| CMF-40281 | EGR1 | down-regulates | hsa-mir-105 | represses | R-3033 | 8 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41290 | TP53 | up-regulates | hsa-mir-105 | represses | R-61 | 8 | 8 | Drugs (1) |
| CMF-41291 | TP53 | up-regulates | hsa-mir-105 | represses | R-2431 | 8 | 8 | Drugs (2) |
| CMF-41292 | TP53 | up-regulates | hsa-mir-105 | represses | R-2451 | 8 | 8 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-41293 | TP53 | up-regulates | hsa-mir-105 | represses | R-651 | 8 | 8 | Drugs (2) |
| CMF-41294 | TP53 | up-regulates | hsa-mir-105 | represses | R-2830 | 8 | 8 | Drugs (2) |
| CMF-41295 | TP53 | up-regulates | hsa-mir-105 | represses | R-2864 | 8 | 8 | Drugs (2) |
| CMF-41296 | TP53 | up-regulates | hsa-mir-105 | represses | R-3033 | 8 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41297 | TP53 | up-regulates | hsa-mir-105 | represses | R-3180 | 8 | 8 | Drugs (1) |
| CMF-42583 | ZIC1 | down-regulates | hsa-mir-105 | represses | R-2451 | 8 | 1 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-42951 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-61 | 8 | 8 | Drugs (1) |
| CMF-42952 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-2431 | 8 | 8 | Drugs (2) |
| CMF-42953 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-2451 | 8 | 8 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-42954 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-651 | 8 | 8 | Drugs (2) |
| CMF-42955 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-2830 | 8 | 8 | Drugs (2) |
| CMF-42956 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-2864 | 8 | 8 | Drugs (2) |
| CMF-42957 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-3033 | 8 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42958 | SEMA3E | down-regulates | hsa-mir-105 | represses | R-3180 | 8 | 8 | Drugs (1) |