Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PAX7 - paired box 7
Function
Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5081 | ENSG00000009709 | PAX7 | P23759 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000009709 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01186 | SKAP2 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01546 | CACNA1B | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-02247 | GPR65 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-02401 | LRP2 | down-regulates | PAX7 | represses | R-3697 | 3 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-02402 | LRP2 | down-regulates | PAX7 | represses | R-3698 | 3 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02982 | HFM1 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-03848 | DSP | down-regulates | PAX7 | represses | R-3698 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04411 | COL12A1 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05954 | SLC9A4 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-07296 | NOD2 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-07729 | CDC27 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-08278 | KIF4A | up-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09378 | CUL1 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-09513 | DOCK11 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-10145 | EML2 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-11500 | KIAA1324L | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-11842 | SKIV2L | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11879 | PALM2-AKAP2 | down-regulates | PAX7 | represses | R-3697 | 3 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-13731 | TUBA3C | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-14390 | SLC4A1 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15661 | DCHS2 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-17156 | CDH18 | down-regulates | PAX7 | represses | R-3697 | 3 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-17157 | CDH18 | down-regulates | PAX7 | represses | R-3698 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17309 | SYNJ2 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18478 | LAMA1 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-19759 | BVES | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20223 | GPR15 | down-regulates | PAX7 | represses | R-3697 | 3 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-20224 | GPR15 | down-regulates | PAX7 | represses | R-3698 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20670 | CYP4B1 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21139 | HUWE1 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21183 | ATM | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-21360 | GRIK3 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23103 | UNC45B | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-23229 | RNF17 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-23337 | CCDC132 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-25440 | PCDHGB3 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-26320 | CHGB | down-regulates | PAX7 | represses | R-3697 | 3 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-26321 | CHGB | down-regulates | PAX7 | represses | R-3698 | 3 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27031 | DNAH5 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-27517 | KRTAP20-2 | down-regulates | PAX7 | represses | R-3698 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28263 | ZIC1 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-28594 | PCDHA7 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-29094 | TUBB4Q | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-30479 | PROKR2 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-30873 | ARMC4 | down-regulates | PAX7 | represses | R-3697 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-31547 | EGF_RECEPTOR_SIGNALING_PATHWAY | down-regulates | PAX7 | represses | R-3697 | 3 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-32810 | E_CADHERIN_SIGNALING_IN_KERATINOCYTES | down-regulates | PAX7 | represses | R-3697 | 3 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-33342 | ERBB1_DOWNSTREAM_SIGNALING | down-regulates | PAX7 | represses | R-3697 | 3 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)AMG-780, MEDI-3617, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |