Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

FEV - FEV transcription factor, ETS family member

Function

Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
54738 ENSG00000163497 FEV Q99581

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000163497 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00062LRP2down-regulatesFEVrepressesR-303052Drugs (71)
CMF-00063LRP2down-regulatesFEVrepressesR-303152Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-01806TMPRSS15down-regulatesFEVrepressesR-303053Drugs (71)
CMF-01807TMPRSS15down-regulatesFEVrepressesR-303353Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-01808TMPRSS15down-regulatesFEVrepressesR-303153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-02245GPR65down-regulatesFEVrepressesR-303151Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-02788DHX30down-regulatesFEVrepressesR-303052Drugs (71)
CMF-02789DHX30down-regulatesFEVrepressesR-303452Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-02979HFM1down-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-03609SSPOdown-regulatesFEVrepressesR-303252Drugs (18)
CMF-03803DSPdown-regulatesFEVrepressesR-303051Drugs (71)
CMF-04108JAG2down-regulatesFEVrepressesR-303151Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-04226RBPJLdown-regulatesFEVrepressesR-303452Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04227RBPJLdown-regulatesFEVrepressesR-303252Drugs (18)
CMF-04465MYH8down-regulatesFEVrepressesR-303453Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04466MYH8down-regulatesFEVrepressesR-303253Drugs (18)
CMF-04467MYH8down-regulatesFEVrepressesR-303153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-04746ADAMTS20down-regulatesFEVrepressesR-303151Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-04847NEFMdown-regulatesFEVrepressesR-303051Drugs (71)
CMF-05144KCNH1down-regulatesFEVrepressesR-303451Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05637ITGB7down-regulatesFEVrepressesR-303452Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05638ITGB7down-regulatesFEVrepressesR-303252Drugs (18)
CMF-06077FGFR3down-regulatesFEVrepressesR-303251Drugs (18)
CMF-06113HTR5Adown-regulatesFEVrepressesR-303251Drugs (18)
CMF-07203NELL1down-regulatesFEVrepressesR-303252Drugs (18)
CMF-07273NOD2down-regulatesFEVrepressesR-303054Drugs (71)
CMF-07274NOD2down-regulatesFEVrepressesR-303354Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07275NOD2down-regulatesFEVrepressesR-303454Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07276NOD2down-regulatesFEVrepressesR-303154Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-08636SLC4A7down-regulatesFEVrepressesR-303151Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-08971GPR132down-regulatesFEVrepressesR-303052Drugs (71)
CMF-08972GPR132down-regulatesFEVrepressesR-303152Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-09424ZIC4down-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-09489DOCK11down-regulatesFEVrepressesR-303151Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-10008ALBdown-regulatesFEVrepressesR-303251Drugs (18)
CMF-10519LRBAdown-regulatesFEVrepressesR-303052Drugs (71)
CMF-10520LRBAdown-regulatesFEVrepressesR-303352Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-10944BMP5down-regulatesFEVrepressesR-303151Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-11548PREX2down-regulatesFEVrepressesR-303251Drugs (18)
CMF-12873ATP11Cdown-regulatesFEVrepressesR-303051Drugs (71)
CMF-14387SLC4A1down-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14620C1orf177down-regulatesFEVrepressesR-303251Drugs (18)
CMF-14748SLC5A12down-regulatesFEVrepressesR-303451Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-15539TAS2R41down-regulatesFEVrepressesR-303151Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-15793GRM3down-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-16698SIdown-regulatesFEVrepressesR-303051Drugs (71)
CMF-16748CPNE8down-regulatesFEVrepressesR-303251Drugs (18)
CMF-17302SYNJ2down-regulatesFEVrepressesR-303053Drugs (71)
CMF-17303SYNJ2down-regulatesFEVrepressesR-303453Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17304SYNJ2down-regulatesFEVrepressesR-303253Drugs (18)
CMF-17384TBC1D8down-regulatesFEVrepressesR-303251Drugs (18)
CMF-17530CNTNAP3down-regulatesFEVrepressesR-303251Drugs (18)
CMF-18332DNMBPdown-regulatesFEVrepressesR-303251Drugs (18)
CMF-18452LAMA1down-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-19068COL4A4down-regulatesFEVrepressesR-303352Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-19069COL4A4down-regulatesFEVrepressesR-303152Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-19150PTPRRdown-regulatesFEVrepressesR-303352Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-19151PTPRRdown-regulatesFEVrepressesR-303152Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-19645RPSAP58down-regulatesFEVrepressesR-303054Drugs (71)
CMF-19646RPSAP58down-regulatesFEVrepressesR-303454Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-19647RPSAP58down-regulatesFEVrepressesR-303254Drugs (18)
CMF-19648RPSAP58down-regulatesFEVrepressesR-303154Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-19693UGT2B4down-regulatesFEVrepressesR-303251Drugs (18)
CMF-20118TDRD9down-regulatesFEVrepressesR-303352Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20119TDRD9down-regulatesFEVrepressesR-303252Drugs (18)
CMF-20173KIAA1598down-regulatesFEVrepressesR-303451Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20211GPR15down-regulatesFEVrepressesR-303052Drugs (71)
CMF-20212GPR15down-regulatesFEVrepressesR-303352Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20303FREM1down-regulatesFEVrepressesR-303052Drugs (71)
CMF-20304FREM1down-regulatesFEVrepressesR-303152Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-20416CUX2down-regulatesFEVrepressesR-303051Drugs (71)
CMF-21045KRTAP4-7down-regulatesFEVrepressesR-303051Drugs (71)
CMF-21163ADAM30down-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21253EGR1down-regulatesFEVrepressesR-303052Drugs (71)
CMF-21254EGR1down-regulatesFEVrepressesR-303352Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21343GRIK3down-regulatesFEVrepressesR-303052Drugs (71)
CMF-21344GRIK3down-regulatesFEVrepressesR-303152Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-21514KLHL34up-regulatesFEVrepressesR-303053Drugs (71)
CMF-21515KLHL34up-regulatesFEVrepressesR-303453Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21516KLHL34up-regulatesFEVrepressesR-303153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-21894PRAMEdown-regulatesFEVrepressesR-303053Drugs (71)
CMF-21895PRAMEdown-regulatesFEVrepressesR-303253Drugs (18)
CMF-21896PRAMEdown-regulatesFEVrepressesR-303153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-24326SMCHD1down-regulatesFEVrepressesR-303452Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24327SMCHD1down-regulatesFEVrepressesR-303252Drugs (18)
CMF-24382PREX1down-regulatesFEVrepressesR-303251Drugs (18)
CMF-24469SEMA3Cup-regulatesFEVrepressesR-303053Drugs (71)
CMF-24470SEMA3Cup-regulatesFEVrepressesR-303353Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24471SEMA3Cup-regulatesFEVrepressesR-303153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-24948NLRP1down-regulatesFEVrepressesR-303453Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24949NLRP1down-regulatesFEVrepressesR-303253Drugs (18)
CMF-24950NLRP1down-regulatesFEVrepressesR-303153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-25426PCDHGB3down-regulatesFEVrepressesR-303352Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25427PCDHGB3down-regulatesFEVrepressesR-303152Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-26584NAALADL1down-regulatesFEVrepressesR-303251Drugs (18)
CMF-27318CHD5down-regulatesFEVrepressesR-303354Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-27319CHD5down-regulatesFEVrepressesR-303454Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-27320CHD5down-regulatesFEVrepressesR-303254Drugs (18)
CMF-27321CHD5down-regulatesFEVrepressesR-303154Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-27506KRTAP20-2down-regulatesFEVrepressesR-303052Drugs (71)
CMF-27507KRTAP20-2down-regulatesFEVrepressesR-303252Drugs (18)
CMF-27608ANKRD36down-regulatesFEVrepressesR-303452Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-27609ANKRD36down-regulatesFEVrepressesR-303252Drugs (18)
CMF-31048PNPLA7down-regulatesFEVrepressesR-303251Drugs (18)
CMF-31456SIGNALING_EVENTS_MEDIATED_BY_TCPTPdown-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-32792E_CADHERIN_SIGNALING_IN_KERATINOCYTESdown-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-33795SIGNALING_EVENTS_MEDIATED_BY_PTP1Bdown-regulatesFEVrepressesR-303351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)