Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation CXCR4_MEDIATED_SIGNALING_EVENTS_PID_NCI_NATURE_nonsilent_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-32476CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesIRF2activatesR-413256Drugs (139)

Regulator Drugs (0)

Regulon Drugs (139)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, UMBRALISIB, FIBOFLAPON SODIUM, ATN-161, BGT-226, SONOLISIB, CSL-324, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, BMS-986142, HM-71224, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, R-348, PF-06651600, AMY-101, LIPEGFILGRASTIM, ABIVERTINIB, VRC-01LS, ABIVERTINIB MALEATE, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, EFALIZUMAB, DACTOLISIB, BOSUTINIB, FILGRASTIM, ZANDELISIB, HMPL-523, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, RILZABRUTINIB, BALUGRASTIM, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, RO-5458640, TASELISIB, L19SIP 131I, AMG-319, IBRUTINIB, TADEKINIG ALFA, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, EVOBRUTINIB, SELGANTOLIMOD, R-333, OTLERTUZUMAB, GUSACITINIB, BI-836826, MOTOLIMOD, TREGALIZUMAB, ERITORAN TETRASODIUM, TG100-801, SPEBRUTINIB BESYLATE, PEGCETACOPLAN, LENOGRASTIM, POSELTINIB, LIFITEGRAST, VB-201, ACALISIB, ZANOLIMUMAB, MIVAVOTINIB CITRATE, VELIFLAPON, PIRTOBRUTINIB, TELRATOLIMOD, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, MILATUZUMAB, VOLOCIXIMAB, FOSTAMATINIB, TOMARALIMAB, ELSUBRUTINIB, BRANEBRUTINIB, LENIOLISIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-32477CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesIRF2activatesR-424256Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-32482CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesNFKB1activatesR-302254Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-32485CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesNFKB1activatesR-290254Drugs (110)
CMF-32487CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesESRRAactivatesR-1968195Drugs (7)
CMF-32491CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesLEF1activatesR-1412186Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-32497CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesMAFactivatesR-173193Drugs (89)
CMF-32511CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5AactivatesR-2950214Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-32513CXCR4_MEDIATED_SIGNALING_EVENTSdown-regulatesEMX1repressesR-3049144Drugs (59)
CMF-32518CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-32519CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154692Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN

CMF-32531CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesCEBPGactivatesR-1047236Drugs (9)
CMF-32537CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesIRF8activatesR-403187Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-32541CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesIRF8activatesR-395187Drugs (75)