Regulon

Regulon: R-1544

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
72.12611130Pr-49Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
4313 ENSG00000087245 MMP2 P08253
1021 ENSG00000105810 CDK6 Q00534
7043 ENSG00000119699 TGFB3 P10600
3709 ENSG00000123104 ITPR2 Q14571
693216 ENSG00000140400 MAN2C1 Q9NTJ4
79839 ENSG00000150636 CCDC102B Q68D86
7767 ENSG00000267680 ZNF224 Q9NZL3

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
BINTRAFUSP ALFATGFB1ProteinBINDING AGENTProgrammed cell death 1 ligand 1 binding agent30
TRILACICLIBCDK6Small moleculeINHIBITORCyclin-dependent kinase 4 inhibitor40
RIBOCICLIBCDK4Small moleculeINHIBITORCyclin-dependent kinase 4 inhibitor41
PALBOCICLIBCDK4Small moleculeINHIBITORCyclin-dependent kinase 4/cyclin D1 inhibitor42
ABEMACICLIBCDK4Small moleculeINHIBITORCyclin-dependent kinase 4 inhibitor42
PHA-793887CDK4Small moleculeINHIBITORCyclin-dependent kinase inhibitor10
LUSPATERCEPTTGFB1ProteinINHIBITORTransforming growth factor beta inhibitor40
AZD-5438CDK4Small moleculeINHIBITORCyclin-dependent kinase inhibitor10
RIBOCICLIB SUCCINATECDK4Small moleculeINHIBITORCyclin-dependent kinase 4 inhibitor40
TRILACICLIB DIHYDROCHLORIDECDK6Small moleculeINHIBITORCyclin-dependent kinase 4 inhibitor40
UCN-01CDK4Small moleculeINHIBITOR3-phosphoinositide dependent protein kinase-1 inhibitor20
ALVOCIDIBCDK6Small moleculeINHIBITORCyclin-dependent kinase 7 inhibitor30
FRESOLIMUMABTGFB2AntibodyINHIBITORTransforming growth factor beta-1 inhibitor20
RONICICLIBCDK4Small moleculeINHIBITORCyclin-dependent kinase inhibitor20
AT-7519CDK4Small moleculeINHIBITORCyclin-dependent kinase inhibitor20
MARIMASTATMMP7Small moleculeINHIBITORMatrix metalloproteinase 9 inhibitor30

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1544

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-14359SIPA1L1up-regulatesSTAT5BactivatesR-154491Drugs (16)
CMF-16572RBM19down-regulatesSTAT5BactivatesR-154494Drugs (16)
CMF-25461PCDHGB3up-regulatesSTAT5BactivatesR-154494Drugs (16)
CMF-31331CLASS_I_PI3K_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-31382ANGIOPOIETIN_RECEPTOR_TIE2_MEDIATED_SIGNALINGup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-31420IL3_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-31679PDGFR_BETA_SIGNALING_PATHWAYup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-31740PAR1_MEDIATED_THROMBIN_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-31795ERBB4_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154494Drugs (16)
CMF-31818SIGNALING_EVENTS_MEDIATED_BY_VEGFR1_AND_VEGFR2up-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-31997E_CADHERIN_SIGNALING_NASCENT_ADHERENS_JUNCTIONup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-32053SIGNALING_EVENTS_MEDIATED_BY_HEPATOCYTE_GFRup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-32178VEGFR3_SIGNALING_IN_LYMPHATIC_ENDOTHELIUMup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-32471IL4_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154491Drugs (16)
CMF-32518CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-32600IL23_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-32704NONGENOTROPIC_ANDROGEN_SIGNALINGup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-33094GMCSF_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-33120IL5_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-33204FC_EPSILON_RECEPTOR_I_SIGNALING_IN_MAST_CELLSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-33245EPHRIN_B_REVERSE_SIGNALINGup-regulatesSTAT5BactivatesR-154494Drugs (16)
CMF-33278IL2_SIGNALING_EVENTS_MEDIATED_BY_PI3Kup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-33503NEPHRIN_NEPH1_SIGNALING_IN_THE_KIDNEY_PODOCYTEup-regulatesSTAT5BactivatesR-154494Drugs (16)
CMF-33609ERBB2_ERBB3_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-33618PLASMA_MEMBRANE_ESTROGEN_RECEPTOR_SIGNALINGup-regulatesSTAT5BactivatesR-154491Drugs (16)
CMF-33689BCR_SIGNALING_PATHWAYup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-33731IL6_MEDIATED_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-33766FGF_SIGNALING_PATHWAYup-regulatesSTAT5BactivatesR-154493Drugs (16)
CMF-33836N_CADHERIN_SIGNALING_EVENTSup-regulatesSTAT5BactivatesR-154492Drugs (16)
CMF-33845P75_MEDIATED_SIGNALINGup-regulatesSTAT5BactivatesR-154492Drugs (16)