Regulon

Regulon: R-395

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
662.38809144Pr-7Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
23129 ENSG00000004399 PLXND1 Q9Y4D7
221 ENSG00000006534 ALDH3B1 P43353
85477 ENSG00000006747 SCIN Q9Y6U3
695 ENSG00000010671 BTK Q06187
9961 ENSG00000013364 MVP Q14764
864 ENSG00000020633 RUNX3 Q13761
50619 ENSG00000023892 DEF6 Q9H4E7
7133 ENSG00000028137 TNFRSF1B P20333
6916 ENSG00000059377 TBXAS1 P24557
11320 ENSG00000071073 MGAT4A Q9UM21
55843 ENSG00000075884 ARHGAP15 Q53QZ3
8569 ENSG00000079277 MKNK1 Q9BUB5
3912 ENSG00000091136 LAMB1 P07942
8829 ENSG00000099250 NRP1 O14786
4627 ENSG00000100345 MYH9 P35579
1522 ENSG00000101160 CTSZ Q9UBR2
3055 ENSG00000101336 HCK P08631
25939 ENSG00000101347 SAMHD1 Q9Y3Z3
29108 ENSG00000103490 PYCARD Q9ULZ3
50615 ENSG00000103522 IL21R Q9HBE5
951 ENSG00000104894 CD37 P11049
22898 ENSG00000105339 DENND3 A2RUS2
51296 ENSG00000110446 SLC15A3 Q8IY34
6404 ENSG00000110876 SELPLG Q14242
10019 ENSG00000111252 SH2B3 Q9UQQ2
202 ENSG00000112297 AIM1 Q96QW7
9450 ENSG00000112799 LY86 O95711
2335 ENSG00000115414 FN1 P02751
5906 ENSG00000116473 RAP1A P62834
56944 ENSG00000116774 OLFML3 Q9NRN5
80231 ENSG00000120280 CXorf21 Q9HAI6
5552 ENSG00000122862 SRGN P10124
22918 ENSG00000125810 CD93 Q9NPY3
1236 ENSG00000126353 CCR7 P32248
10095 ENSG00000130429 ARPC1B O15143
9535 ENSG00000130755 GMFG O60234
27141 ENSG00000136305 CIDEB Q9UHD4
1318 ENSG00000136867 SLC31A2 O15432
7057 ENSG00000137801 THBS1 P07996
11010 ENSG00000139278 GLIPR1 B4E3S5
8477 ENSG00000140030 GPR65 Q8IYL9
23533 ENSG00000141506 PIK3R5 Q8WYR1
6518 ENSG00000142583 SLC2A5 P22732
963 ENSG00000143119 CD53 P19397
3606 ENSG00000150782 IL18 Q14116
23643 ENSG00000154589 LY96 Q9Y6Y9
64092 ENSG00000155307 SAMSN1 Q9NSI8
9056 ENSG00000155465 SLC7A7 Q9UM01
81035 ENSG00000158270 COLEC12 Q5KU26
2207 ENSG00000158869 FCER1G P30273
6464 ENSG00000160691 SHC1 P29353
3570 ENSG00000160712 IL6R P08887
7805 ENSG00000162511 LAPTM5 Q13571
114548 ENSG00000162711 NLRP3 A0A7I2PRX0
26225 ENSG00000162980 ARL5A Q9Y689
1520 ENSG00000163131 CTSS A0A7P0TB77
7048 ENSG00000163513 TGFBR2 A3QNQ0
1508 ENSG00000164733 CTSB E9PSG5
7096 ENSG00000174125 TLR1 Q15399
2 ENSG00000175899 A2M P01023
4261 ENSG00000179583 CIITA Q29704
4600 ENSG00000183486 MX2 P20592
7100 ENSG00000187554 TLR5 B1AZ06
51393 ENSG00000187688 TRPV2 Q9Y5S1
26112 ENSG00000198624 CCDC69 A6NI79
10628 ENSG00000265972 TXNIP Q9H3M7

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
PF-04691502PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
PICOTAMIDETBXAS1Small moleculeINHIBITORThromboxane-A synthase inhibitor40
BGT-226PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
SONOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
TERBOGRELTBXA2RSmall moleculeINHIBITORThromboxane-A synthase inhibitor20
VOXTALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor21
BMS-986142BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
HM-71224BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor10
APITOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
DASATINIBABL1Small moleculeINHIBITORPlatelet-derived growth factor receptor beta inhibitor42
DS-7423PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
L19IL2FN1AntibodyBINDING AGENTFibronectin binding agent30
MSC-2364447BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor10
PAXALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
AS-1409FN1AntibodyBINDING AGENTFibronectin binding agent10
PICTILISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
PF-06651600BTKSmall moleculeINHIBITORTEC family kinase inhibitor30
ABIVERTINIBBTKSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor30
ABIVERTINIB MALEATEEGFRSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
MEDI-2338IL18AntibodyCROSS-LINKING AGENTInterleukin-18 cross-linking agent10
VS-5584PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
SAMOTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
VOBARILIZUMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor20
L19TNFAFN1AntibodyBINDING AGENTFibronectin binding agent20
DACTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor30
BOSUTINIBABL1Small moleculeINHIBITORBcr/Abl fusion protein42
TOCILIZUMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor42
GNF-Pf-5468PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
WX-037PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
RILZABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
SPEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
PILARALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor21
ILORASERTIBPDGFRBSmall moleculeINHIBITORSerine/threonine-protein kinase Aurora inhibitor20
DAPANSUTRILENLRP3Small moleculeINHIBITORNACHT, LRR and PYD domains-containing protein 3 inhibitor20
TASELISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor30
L19SIP 131IFN1AntibodyOTHERFibronectin other20
IBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor41
TADEKINIG ALFAIL18ProteinINHIBITORInterleukin-18 inhibitor30
PETESICATIBCTSSSmall moleculeINHIBITORCathepsin S inhibitor20
GEDATOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
OMIPALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
SARILUMABIL6RAntibodyANTAGONISTInterleukin-6 receptor alpha subunit antagonist40
NEIHULIZUMABSELPLGAntibodyINHIBITORP-selectin glycoprotein ligand 1 inhibitor20
ENTOLIMODTLR5UnknownAGONISTToll-like receptor 5 agonist20
ZANUBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor40
XL-228ABL1Small moleculeINHIBITORTyrosine-protein kinase ABL inhibitor10
SATRALIZUMABIL6RAntibodyANTAGONISTIL6Ralpha/GP130 antagonist40
EVOBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
OTLERTUZUMABCD37AntibodyBINDING AGENTLeukocyte antigen CD37 binding agent10
BI-836826CD37UnknownINHIBITORLeukocyte antigen CD37 inhibitor20
ERITORAN TETRASODIUMTLR4Small moleculeANTAGONISTToll-like receptor 4/MD-2 antagonist30
TOMIVOSERTIBMKNK2Small moleculeINHIBITORMAP kinase-interacting serine/threonine-protein kinase 1/2 inhibitor20
TG100-801EPHB4Small moleculeINHIBITORSRC inhibitor20
SPEBRUTINIB BESYLATEBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
POSELTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
PIRTOBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
OCRIPLASMINLAMA2EnzymePROTEOLYTIC ENZYMEFibronectin proteolytic enzyme40
ACALABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor41
ERITORANTLR4Small moleculeANTAGONISTToll-like receptor 4/MD-2 antagonist30
ELSUBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
BRANEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
OZAGRELTBXAS1Small moleculeINHIBITORThromboxane-A synthase inhibitor30
PA-799PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
TIRABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
FENEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
LEVILIMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor30
GSK-1059615PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
BUPARLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor32
VESENCUMABNRP1AntibodyINHIBITORNeuropilin-1 inhibitor10
NARATUXIMAB EMTANSINECD37AntibodyBINDING AGENTLeukocyte antigen CD37 binding agent10
SF-1126PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
ORELABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
GSK-1070806IL18AntibodyINHIBITORInterleukin-18 inhibitor20
ENMD-981693PDGFRBSmall moleculeINHIBITORPlatelet-derived growth factor receptor inhibitor20
PANULISIBACVRL1Small moleculeINHIBITORSerine/threonine-protein kinase receptor R3 inhibitor10

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-395

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-07594AHNAK2down-regulatesIRF8activatesR-395184Drugs (75)
CMF-11442CYP4F22up-regulatesIRF8activatesR-395187Drugs (75)
CMF-13856ADAMTS8down-regulatesIRF8activatesR-395184Drugs (75)
CMF-14643C1orf177up-regulatesIRF8activatesR-395182Drugs (75)
CMF-14882COL6A2up-regulatesIRF8activatesR-395181Drugs (75)
CMF-15230OR51F1down-regulatesIRF8activatesR-395188Drugs (75)
CMF-15497ZFP57down-regulatesIRF8activatesR-395181Drugs (75)
CMF-15869ZNF845down-regulatesIRF8activatesR-395184Drugs (75)
CMF-19673RPSAP58up-regulatesIRF8activatesR-395185Drugs (75)
CMF-27236PCDH11Xdown-regulatesIRF8activatesR-395181Drugs (75)
CMF-28744SYN3down-regulatesIRF8activatesR-395184Drugs (75)
CMF-31186LRFN2down-regulatesIRF8activatesR-395184Drugs (75)
CMF-35053FGFR3down-regulateshsa-mir-454-3prepressesR-3953129Drugs (75)
CMF-35085FGFR3down-regulateshsa-mir-20brepressesR-3954426Drugs (75)
CMF-35975AHNAK2up-regulateshsa-mir-106brepressesR-3952116Drugs (75)
CMF-35997AHNAK2up-regulateshsa-mir-93repressesR-3954426Drugs (75)
CMF-36025AHNAK2up-regulateshsa-mir-20brepressesR-3954426Drugs (75)
CMF-36156TNK2up-regulateshsa-mir-17-3prepressesR-3955240Drugs (75)
CMF-36691ATP8A2up-regulateshsa-mir-454-3prepressesR-3953127Drugs (75)
CMF-36732ATP8A2up-regulateshsa-mir-17-3prepressesR-3955240Drugs (75)
CMF-36762ATP8A2up-regulateshsa-mir-93repressesR-3954432Drugs (75)
CMF-36796ATP8A2up-regulateshsa-mir-20brepressesR-3954431Drugs (75)
CMF-37699ADAMTS8up-regulateshsa-mir-17-3prepressesR-3955240Drugs (75)
CMF-37963COL6A2down-regulateshsa-mir-17-3prepressesR-3955217Drugs (75)
CMF-38089OR51F1up-regulateshsa-mir-106brepressesR-3952117Drugs (75)
CMF-38109OR51F1up-regulateshsa-mir-93repressesR-3954435Drugs (75)
CMF-38323ZNF845up-regulateshsa-mir-454-3prepressesR-3953127Drugs (75)
CMF-39144DNMBPdown-regulateshsa-mir-17-3prepressesR-3955235Drugs (75)
CMF-39561NF1down-regulateshsa-mir-106brepressesR-3952120Drugs (75)
CMF-39629NF1down-regulateshsa-mir-93repressesR-3954431Drugs (75)
CMF-39720NF1down-regulateshsa-mir-20brepressesR-3954431Drugs (75)
CMF-39774RPSAP58down-regulateshsa-mir-17-3prepressesR-3955240Drugs (75)
CMF-39828UGT2B4down-regulateshsa-mir-149repressesR-3955135Drugs (75)
CMF-39933TDRD9down-regulateshsa-mir-106brepressesR-3952121Drugs (75)
CMF-39966TDRD9down-regulateshsa-mir-17-3prepressesR-3955242Drugs (75)
CMF-41340TP53up-regulateshsa-mir-17-3prepressesR-3955252Drugs (75)
CMF-41383TP53up-regulateshsa-mir-93repressesR-3954444Drugs (75)
CMF-41545TP53up-regulateshsa-mir-20brepressesR-3954444Drugs (75)
CMF-41775IQSEC3up-regulateshsa-mir-454-3prepressesR-3953125Drugs (75)
CMF-41906IQSEC3up-regulateshsa-mir-20brepressesR-3954434Drugs (75)
CMF-31341CLASS_I_PI3K_SIGNALING_EVENTSup-regulatesIRF8activatesR-395183Drugs (75)
CMF-31701PDGFR_BETA_SIGNALING_PATHWAYup-regulatesIRF8activatesR-395184Drugs (75)
CMF-32541CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesIRF8activatesR-395187Drugs (75)
CMF-33697BCR_SIGNALING_PATHWAYup-regulatesIRF8activatesR-395183Drugs (75)