Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

LEF1 - lymphoid enhancer binding factor 1

Function

Isoform 5Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
51176 ENSG00000138795 LEF1 Q9UJU2

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000138795 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01058ZNF292down-regulatesLEF1activatesR-1408184Drugs (19)
CMF-04452MYH8up-regulatesLEF1activatesR-1408185Drugs (19)
CMF-06762ATRXdown-regulatesLEF1activatesR-14181812Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-06763ATRXdown-regulatesLEF1activatesR-14081812Drugs (19)
CMF-06764ATRXdown-regulatesLEF1activatesR-14121812Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-06770ATRXdown-regulatesLEF1activatesR-14251812Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-13765ADAMTS8down-regulatesLEF1activatesR-1412184Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-13768ADAMTS8down-regulatesLEF1activatesR-1425184Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-14055ANO9down-regulatesLEF1activatesR-1412182Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-14292STK31down-regulatesLEF1activatesR-1412182Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-15252HCN1up-regulatesLEF1activatesR-1412183Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-15253HCN1up-regulatesLEF1activatesR-1425183Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-16026NFIXup-regulatesLEF1activatesR-1408184Drugs (19)
CMF-18694MPP7down-regulatesLEF1activatesR-1425182Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-22067SSTR4up-regulatesLEF1activatesR-1418182Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22386IDH1down-regulatesLEF1activatesR-14181813Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22387IDH1down-regulatesLEF1activatesR-14081813Drugs (19)
CMF-22388IDH1down-regulatesLEF1activatesR-14121813Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-22394IDH1down-regulatesLEF1activatesR-14251813Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-24590THADAdown-regulatesLEF1activatesR-1425182Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-28396MYO9Bdown-regulatesLEF1activatesR-1412186Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-28399MYO9Bdown-regulatesLEF1activatesR-1425186Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-29108FOLH1Bdown-regulatesLEF1activatesR-1418184Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-29109FOLH1Bdown-regulatesLEF1activatesR-1408184Drugs (19)
CMF-29110FOLH1Bdown-regulatesLEF1activatesR-1412184Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-29605ESRRBdown-regulatesLEF1activatesR-1412185Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-31308CLASS_I_PI3K_SIGNALING_EVENTSup-regulatesLEF1activatesR-1412184Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-31641PDGFR_BETA_SIGNALING_PATHWAYup-regulatesLEF1activatesR-1412185Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-32491CXCR4_MEDIATED_SIGNALING_EVENTSup-regulatesLEF1activatesR-1412186Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-33404TCR_SIGNALING_IN_NAIVE_CD4+_T_CELLSup-regulatesLEF1activatesR-1418185Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-33405TCR_SIGNALING_IN_NAIVE_CD4+_T_CELLSup-regulatesLEF1activatesR-1408185Drugs (19)
CMF-33406TCR_SIGNALING_IN_NAIVE_CD4+_T_CELLSup-regulatesLEF1activatesR-1412185Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB