Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation ADCY1_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-20532ADCY1down-regulatesFGF9repressesR-176842Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BIVATUZUMAB

CMF-20533ADCY1down-regulatesFGF9repressesR-176742Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

GSK-1995057, VANTICTUMAB

CMF-20534ADCY1down-regulatesNR2F1repressesR-2781152Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-20535ADCY1down-regulatesNR2F1repressesR-2778152Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20537ADCY1up-regulatesNFKB1activatesR-300255Drugs (23)
CMF-20538ADCY1up-regulatesNFKB1activatesR-294255Drugs (5)
CMF-20540ADCY1up-regulatesNFKB1activatesR-292255Drugs (20)
CMF-20541ADCY1down-regulatesSATB1activatesR-1693248Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20543ADCY1down-regulatesSATB1repressesR-1680248Drugs (7)
CMF-20544ADCY1down-regulatesSATB1repressesR-1684248Drugs (9)
CMF-20547ADCY1down-regulatesSATB1repressesR-1676248Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

DAVANAT, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A

CMF-20551ADCY1down-regulatesLHX1repressesR-2971174Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20560ADCY1up-regulatesPPARGactivatesR-2317152Drugs (8)
CMF-20563ADCY1up-regulatesMAFBactivatesR-1901256Drugs (44)
CMF-20565ADCY1up-regulatesMAFBactivatesR-1900256Drugs (20)
CMF-20567ADCY1up-regulatesMAFBactivatesR-1904256Drugs (8)
CMF-20571ADCY1down-regulatesALX4repressesR-2926205Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20573ADCY1down-regulatesPOU4F1repressesR-2763113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ASK-8007

CMF-20575ADCY1down-regulatesPOU4F1activatesR-2764113Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20577ADCY1down-regulatesMAZactivatesR-613254Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

EFLORNITHINE, EFLORNITHINE HYDROCHLORIDE

CMF-20581ADCY1down-regulatesLHX3repressesR-2011243Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20582ADCY1down-regulatesLHX3repressesR-2015243Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20583ADCY1down-regulatesLHX3repressesR-2007243Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL

CMF-20587ADCY1down-regulatesEMX1repressesR-3039142Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

EMRICASAN

CMF-20592ADCY1down-regulatesPOU4F2repressesR-2790131Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ASK-8007

CMF-20596ADCY1down-regulatesE2F1activatesR-530184Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

EDIFOLIGIDE SODIUM

CMF-20597ADCY1down-regulatesPBX1repressesR-3161121Drugs (7)

Regulator Drugs (0)

Regulon Drugs (7)

ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB

CMF-20599ADCY1down-regulatesNKX6-1repressesR-2852203Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20601ADCY1up-regulatesVDRactivatesR-245142Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-20602ADCY1down-regulatesMNX1activatesR-226141Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20606ADCY1down-regulatesSOX2repressesR-2687162Drugs (9)
CMF-20607ADCY1up-regulatesLTFrepressesR-360121Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20610ADCY1down-regulatesMYCNrepressesR-180753Drugs (5)
CMF-20612ADCY1down-regulatesSCRT1repressesR-10941Drugs (17)
CMF-20615ADCY1down-regulatesSOX3repressesR-173063Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20616ADCY1down-regulatesSOX3repressesR-173163Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-20618ADCY1down-regulatesKLF12repressesR-312041Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DAVANAT, PEGINTERFERON LAMBDA-1A

CMF-20620ADCY1down-regulatesFOXA2repressesR-2020112Drugs (112)

Regulator Drugs (0)

Regulon Drugs (112)

CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, EPELSIBAN, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, OXYTOCIN, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, CARBETOCIN, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, NOLASIBAN, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, ATOSIBAN, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, FE 202767, MIZOLASTINE, HYDROXYZINE PAMOATE, BARUSIBAN, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, ROCURONIUM, CETIRIZINE, RETOSIBAN, METHDILAZINE, DAVALINTIDE

CMF-20626ADCY1down-regulatesFOXO4repressesR-3103173Drugs (8)
CMF-20627ADCY1down-regulatesNR0B1repressesR-253231Drugs (8)

Regulator Drugs (0)

Regulon Drugs (8)

ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB

CMF-40071ADCY1down-regulateshsa-mir-139repressesR-1671581Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BARDOXOLONE METHYL

CMF-40072ADCY1up-regulateshsa-mir-222repressesR-85832Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

SELPERCATINIB, PRALSETINIB

CMF-40073ADCY1up-regulateshsa-mir-222repressesR-166332Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

SELPERCATINIB, PRALSETINIB

CMF-40074ADCY1down-regulateshsa-mir-129repressesR-12941551Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT