Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
LTF - lactotransferrin
Function
Isoform DeltaLfTranscription factor with antiproliferative properties and ability to induce cell cycle arrest (PubMed:15222485). Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters (PubMed:22320386).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 4057 | ENSG00000012223 | LTF | P02788 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000012223 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00295 | SPTA1 | up-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00696 | HMCN1 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-00751 | DNAH5 | up-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06001 | C4orf35 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-07063 | ATRX | down-regulates | LTF | activates | R-3602 | 2 | 2 | Drugs (1) |
| CMF-07064 | ATRX | down-regulates | LTF | represses | R-3601 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12651 | REN | down-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13587 | FMN1 | up-regulates | LTF | activates | R-3602 | 2 | 2 | Drugs (1) |
| CMF-13971 | REM1 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-14639 | C1orf177 | up-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17348 | CDKL5 | down-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-18095 | DLGAP2 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-20232 | GPR15 | up-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20607 | ADCY1 | up-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21077 | KRTAP4-7 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-22823 | IDH1 | down-regulates | LTF | activates | R-3602 | 2 | 2 | Drugs (1) |
| CMF-22824 | IDH1 | down-regulates | LTF | represses | R-3601 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23342 | CCDC132 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-23981 | TP53 | down-regulates | LTF | activates | R-3602 | 2 | 2 | Drugs (1) |
| CMF-23982 | TP53 | down-regulates | LTF | represses | R-3601 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24231 | LRRC7 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-24766 | CHAT | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-26496 | EGFR | up-regulates | LTF | activates | R-3602 | 2 | 2 | Drugs (1) |
| CMF-26497 | EGFR | up-regulates | LTF | represses | R-3601 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27255 | PDYN | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-28234 | REPIN1 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-28906 | NR1H4 | up-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30310 | MSR1 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |