Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
NR0B1 - nuclear receptor subfamily 0 group B member 1
Function
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 190 | ENSG00000169297 | NR0B1 | P51843 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000169297 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00730 | HMCN1 | down-regulates | NR0B1 | represses | R-2533 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01356 | SDPR | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-01517 | MTOR | down-regulates | NR0B1 | represses | R-2532 | 3 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-03152 | EEF1A1 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-03537 | GRIN2A | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-04354 | RBPJL | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04789 | ADAMTS20 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-05341 | PCSK6 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-05420 | KDELC2 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-05990 | SIRPG | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-07193 | ATRX | up-regulates | NR0B1 | represses | R-2532 | 3 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-07195 | ATRX | up-regulates | NR0B1 | represses | R-2533 | 3 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07465 | THOC2 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-08722 | MYH14 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-10157 | FRAS1 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-11341 | RPTN | down-regulates | NR0B1 | represses | R-2532 | 3 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-12785 | ACACB | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-14222 | ZNF516 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15475 | DSE | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-15568 | TAS2R41 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-15711 | DCHS2 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16106 | NFIX | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-16266 | USP11 | up-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16692 | DNAJC11 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-17181 | CDH18 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18327 | MEGF8 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18527 | LAMA1 | down-regulates | NR0B1 | represses | R-2532 | 3 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-18529 | LAMA1 | down-regulates | NR0B1 | represses | R-2533 | 3 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18854 | SLFN13 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-20164 | TDRD9 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20331 | FREM1 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-20627 | ADCY1 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-20695 | CYP4B1 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21118 | KRTAP4-7 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21271 | EGR1 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23015 | IDH1 | up-regulates | NR0B1 | represses | R-2532 | 3 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-23017 | IDH1 | up-regulates | NR0B1 | represses | R-2533 | 3 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23301 | RNF17 | down-regulates | NR0B1 | represses | R-2532 | 3 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-24128 | TP53 | up-regulates | NR0B1 | represses | R-2532 | 3 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-24130 | TP53 | up-regulates | NR0B1 | represses | R-2533 | 3 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25487 | PCDHGB3 | down-regulates | NR0B1 | represses | R-2533 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26347 | CHGB | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-26616 | NAALADL1 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26803 | PCDHA1 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-27534 | KRTAP20-2 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-27664 | ANKRD36 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29900 | ABCC9 | down-regulates | NR0B1 | represses | R-2533 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |