Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PLAG1 - PLAG1 zinc finger
Function
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5324 | ENSG00000181690 | PLAG1 | Q6DJT9 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000181690 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00363 | COL6A3 | up-regulates | PLAG1 | activates | R-2509 | 5 | 4 | Drugs (2) |
| CMF-00364 | COL6A3 | up-regulates | PLAG1 | activates | R-2508 | 5 | 4 | Drugs (4) |
| CMF-00365 | COL6A3 | up-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-00366 | COL6A3 | up-regulates | PLAG1 | activates | R-2510 | 5 | 4 | Drugs (5) |
| CMF-01153 | ZNF292 | down-regulates | PLAG1 | activates | R-2509 | 5 | 2 | Drugs (2) |
| CMF-01154 | ZNF292 | down-regulates | PLAG1 | activates | R-2508 | 5 | 2 | Drugs (4) |
| CMF-02007 | PCDH9 | down-regulates | PLAG1 | activates | R-2510 | 5 | 1 | Drugs (5) |
| CMF-03288 | HRNR | down-regulates | PLAG1 | activates | R-2510 | 5 | 1 | Drugs (5) |
| CMF-05353 | AMAC1 | down-regulates | PLAG1 | activates | R-2509 | 5 | 1 | Drugs (2) |
| CMF-05790 | ADAMTS19 | down-regulates | PLAG1 | activates | R-2509 | 5 | 3 | Drugs (2) |
| CMF-05791 | ADAMTS19 | down-regulates | PLAG1 | activates | R-2512 | 5 | 3 | Drugs (2) |
| CMF-05792 | ADAMTS19 | down-regulates | PLAG1 | activates | R-2510 | 5 | 3 | Drugs (5) |
| CMF-06315 | AFF2 | down-regulates | PLAG1 | activates | R-2510 | 5 | 1 | Drugs (5) |
| CMF-06549 | SETD2 | down-regulates | PLAG1 | activates | R-2510 | 5 | 1 | Drugs (5) |
| CMF-09289 | RP1 | down-regulates | PLAG1 | activates | R-2509 | 5 | 3 | Drugs (2) |
| CMF-09290 | RP1 | down-regulates | PLAG1 | activates | R-2512 | 5 | 3 | Drugs (2) |
| CMF-09291 | RP1 | down-regulates | PLAG1 | activates | R-2510 | 5 | 3 | Drugs (5) |
| CMF-12376 | GPR98 | down-regulates | PLAG1 | activates | R-2508 | 5 | 3 | Drugs (4) |
| CMF-12377 | GPR98 | down-regulates | PLAG1 | activates | R-2512 | 5 | 3 | Drugs (2) |
| CMF-12378 | GPR98 | down-regulates | PLAG1 | activates | R-2510 | 5 | 3 | Drugs (5) |
| CMF-14377 | ST18 | down-regulates | PLAG1 | activates | R-2510 | 5 | 1 | Drugs (5) |
| CMF-17686 | MRPL32 | down-regulates | PLAG1 | activates | R-2508 | 5 | 1 | Drugs (4) |
| CMF-18115 | KCNH5 | down-regulates | PLAG1 | activates | R-2510 | 5 | 1 | Drugs (5) |
| CMF-19596 | NF1 | up-regulates | PLAG1 | activates | R-2509 | 5 | 4 | Drugs (2) |
| CMF-19597 | NF1 | up-regulates | PLAG1 | activates | R-2508 | 5 | 4 | Drugs (4) |
| CMF-19598 | NF1 | up-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-19599 | NF1 | up-regulates | PLAG1 | activates | R-2510 | 5 | 4 | Drugs (5) |
| CMF-25114 | IQSEC3 | down-regulates | PLAG1 | activates | R-2509 | 5 | 1 | Drugs (2) |
| CMF-25180 | ABCA9 | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-25354 | PARG | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-26723 | ITGA10 | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-28297 | KRTAP4-8 | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-28454 | MYO9B | down-regulates | PLAG1 | activates | R-2509 | 5 | 4 | Drugs (2) |
| CMF-28455 | MYO9B | down-regulates | PLAG1 | activates | R-2508 | 5 | 4 | Drugs (4) |
| CMF-28456 | MYO9B | down-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-28457 | MYO9B | down-regulates | PLAG1 | activates | R-2510 | 5 | 4 | Drugs (5) |
| CMF-28676 | PCNX | down-regulates | PLAG1 | activates | R-2510 | 5 | 1 | Drugs (5) |
| CMF-29137 | FOLH1B | down-regulates | PLAG1 | activates | R-2509 | 5 | 2 | Drugs (2) |
| CMF-29138 | FOLH1B | down-regulates | PLAG1 | activates | R-2508 | 5 | 2 | Drugs (4) |