Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation MYO9B_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-28387 | MYO9B | down-regulates | TEAD4 | activates | R-3367 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28389 | MYO9B | up-regulates | SATB1 | represses | R-1684 | 24 | 4 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-28391 | MYO9B | up-regulates | SATB1 | represses | R-1676 | 24 | 4 | Drugs (4) |
| CMF-28392 | MYO9B | down-regulates | ATF3 | activates | R-466 | 5 | 2 | Drugs (4) |
| CMF-28393 | MYO9B | down-regulates | ATF3 | activates | R-467 | 5 | 2 | Drugs (5) |
| CMF-28396 | MYO9B | down-regulates | LEF1 | activates | R-1412 | 18 | 6 | Drugs (3) |
| CMF-28399 | MYO9B | down-regulates | LEF1 | activates | R-1425 | 18 | 6 | Drugs (2) |
| CMF-28401 | MYO9B | down-regulates | ARID3A | activates | R-680 | 19 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-28404 | MYO9B | down-regulates | HLX | activates | R-3580 | 10 | 5 | Drugs (3) |
| CMF-28406 | MYO9B | down-regulates | HLX | activates | R-3582 | 10 | 5 | Drugs (4) |
| CMF-28408 | MYO9B | down-regulates | RUNX1 | activates | R-276 | 15 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, DAVANAT, NATALIZUMAB, FIRATEGRAST, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-28413 | MYO9B | down-regulates | RUNX1 | activates | R-283 | 15 | 7 | Drugs (5) |
| CMF-28415 | MYO9B | down-regulates | PRRX2 | activates | R-3726 | 11 | 1 | Drugs (2) |
| CMF-28416 | MYO9B | down-regulates | ARID5A | activates | R-166 | 15 | 5 | Drugs (1) |
| CMF-28419 | MYO9B | down-regulates | ARID5A | activates | R-165 | 15 | 5 | Drugs (5) |
| CMF-28423 | MYO9B | down-regulates | GATA6 | activates | R-1256 | 18 | 3 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-28425 | MYO9B | down-regulates | SP1 | activates | R-1376 | 8 | 1 | Drugs (1) |
| CMF-28426 | MYO9B | down-regulates | CREB3L2 | activates | R-3124 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-28428 | MYO9B | down-regulates | TFCP2L1 | activates | R-2535 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28429 | MYO9B | down-regulates | HMGA2 | activates | R-3603 | 2 | 1 | Drugs (3) |
| CMF-28430 | MYO9B | down-regulates | CREB3L1 | activates | R-3094 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-28431 | MYO9B | down-regulates | NR1H2 | activates | R-3606 | 4 | 3 | Drugs (1) |
| CMF-28436 | MYO9B | down-regulates | VDR | activates | R-245 | 14 | 5 | Drugs (5) |
| CMF-28438 | MYO9B | down-regulates | VDR | activates | R-240 | 14 | 5 | Drugs (3) |
| CMF-28440 | MYO9B | down-regulates | FOXC2 | represses | R-2644 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28441 | MYO9B | up-regulates | SOX2 | represses | R-2687 | 16 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-28442 | MYO9B | up-regulates | SOX2 | represses | R-2688 | 16 | 2 | Drugs (90) Regulator Drugs (0)Regulon Drugs (90)IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, CANAKINUMAB, MELOXICAM, BROMFENAC SODIUM, RILONACEPT, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, GEVOKIZUMAB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ICATIBANT ACETATE, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, LABRADIMIL, IBUPROFEN SODIUM, LUTIKIZUMAB, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, FASITIBANT, POLMACOXIB, ICATIBANT, ZILTIVEKIMAB |
| CMF-28445 | MYO9B | down-regulates | MZF1 | activates | R-1013 | 16 | 2 | Drugs (1) |
| CMF-28447 | MYO9B | down-regulates | REL | activates | R-252 | 8 | 4 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-28448 | MYO9B | down-regulates | REL | activates | R-248 | 8 | 4 | Drugs (2) |
| CMF-28450 | MYO9B | down-regulates | RARG | activates | R-2805 | 6 | 1 | Drugs (5) |
| CMF-28452 | MYO9B | down-regulates | BACH1 | activates | R-2754 | 11 | 3 | Drugs (1) |
| CMF-28453 | MYO9B | down-regulates | BACH1 | activates | R-2747 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28454 | MYO9B | down-regulates | PLAG1 | activates | R-2509 | 5 | 4 | Drugs (2) |
| CMF-28455 | MYO9B | down-regulates | PLAG1 | activates | R-2508 | 5 | 4 | Drugs (4) |
| CMF-28456 | MYO9B | down-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-28457 | MYO9B | down-regulates | PLAG1 | activates | R-2510 | 5 | 4 | Drugs (5) |
| CMF-28458 | MYO9B | down-regulates | NFYA | activates | R-510 | 11 | 1 | Drugs (5) |
| CMF-42614 | MYO9B | up-regulates | hsa-mir-33 | represses | R-61 | 29 | 8 | Drugs (1) |
| CMF-42615 | MYO9B | up-regulates | hsa-mir-33 | represses | R-2431 | 29 | 8 | Drugs (2) |
| CMF-42616 | MYO9B | up-regulates | hsa-mir-33 | represses | R-651 | 29 | 8 | Drugs (2) |
| CMF-42617 | MYO9B | up-regulates | hsa-mir-33 | represses | R-2830 | 29 | 8 | Drugs (2) |
| CMF-42618 | MYO9B | up-regulates | hsa-mir-33 | represses | R-2864 | 29 | 8 | Drugs (2) |
| CMF-42619 | MYO9B | up-regulates | hsa-mir-33 | represses | R-2940 | 29 | 8 | Drugs (2) |
| CMF-42620 | MYO9B | up-regulates | hsa-mir-33 | represses | R-3033 | 29 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42621 | MYO9B | up-regulates | hsa-mir-33 | represses | R-3180 | 29 | 8 | Drugs (1) |
| CMF-42622 | MYO9B | up-regulates | hsa-mir-330 | represses | R-2196 | 15 | 13 | Drugs (1) |
| CMF-42623 | MYO9B | up-regulates | hsa-mir-330 | represses | R-166 | 15 | 13 | Drugs (1) |
| CMF-42624 | MYO9B | up-regulates | hsa-mir-330 | represses | R-218 | 15 | 13 | Drugs (3) |
| CMF-42625 | MYO9B | up-regulates | hsa-mir-330 | represses | R-2459 | 15 | 13 | Drugs (3) |
| CMF-42626 | MYO9B | up-regulates | hsa-mir-330 | represses | R-655 | 15 | 13 | Drugs (3) |
| CMF-42627 | MYO9B | up-regulates | hsa-mir-330 | represses | R-2710 | 15 | 13 | Drugs (1) |
| CMF-42628 | MYO9B | up-regulates | hsa-mir-330 | represses | R-2760 | 15 | 13 | Drugs (3) |
| CMF-42629 | MYO9B | up-regulates | hsa-mir-330 | represses | R-2892 | 15 | 13 | Drugs (3) |
| CMF-42630 | MYO9B | up-regulates | hsa-mir-330 | represses | R-2950 | 15 | 13 | Drugs (3) |
| CMF-42631 | MYO9B | up-regulates | hsa-mir-330 | represses | R-1312 | 15 | 13 | Drugs (2) |
| CMF-42632 | MYO9B | up-regulates | hsa-mir-330 | represses | R-1546 | 15 | 13 | Drugs (1) |
| CMF-42633 | MYO9B | up-regulates | hsa-mir-330 | represses | R-3643 | 15 | 13 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42634 | MYO9B | up-regulates | hsa-mir-330 | represses | R-2006 | 15 | 13 | Drugs (3) |
| CMF-42635 | MYO9B | up-regulates | hsa-mir-129 | represses | R-61 | 155 | 15 | Drugs (1) |
| CMF-42636 | MYO9B | up-regulates | hsa-mir-129 | represses | R-2395 | 155 | 15 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-42637 | MYO9B | up-regulates | hsa-mir-129 | represses | R-2431 | 155 | 15 | Drugs (2) |
| CMF-42638 | MYO9B | up-regulates | hsa-mir-129 | represses | R-2585 | 155 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42639 | MYO9B | up-regulates | hsa-mir-129 | represses | R-572 | 155 | 15 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-42640 | MYO9B | up-regulates | hsa-mir-129 | represses | R-646 | 155 | 15 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)ALEPLASININ, SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, BHQ-880, VESENCUMAB, ABITUZUMAB |
| CMF-42641 | MYO9B | up-regulates | hsa-mir-129 | represses | R-651 | 155 | 15 | Drugs (2) |
| CMF-42642 | MYO9B | up-regulates | hsa-mir-129 | represses | R-2830 | 155 | 15 | Drugs (2) |
| CMF-42643 | MYO9B | up-regulates | hsa-mir-129 | represses | R-2864 | 155 | 15 | Drugs (2) |
| CMF-42644 | MYO9B | up-regulates | hsa-mir-129 | represses | R-2940 | 155 | 15 | Drugs (2) |
| CMF-42645 | MYO9B | up-regulates | hsa-mir-129 | represses | R-2972 | 155 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42646 | MYO9B | up-regulates | hsa-mir-129 | represses | R-3010 | 155 | 15 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)SULTHIAME, CILENGITIDE, SENICAPOC, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, ABITUZUMAB |
| CMF-42647 | MYO9B | up-regulates | hsa-mir-129 | represses | R-3033 | 155 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42648 | MYO9B | up-regulates | hsa-mir-129 | represses | R-3061 | 155 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42649 | MYO9B | up-regulates | hsa-mir-129 | represses | R-3180 | 155 | 15 | Drugs (1) |
| CMF-42650 | MYO9B | up-regulates | hsa-mir-101 | represses | R-2395 | 8 | 1 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-42651 | MYO9B | up-regulates | hsa-mir-338 | represses | R-61 | 79 | 21 | Drugs (1) |
| CMF-42652 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2196 | 79 | 21 | Drugs (1) |
| CMF-42653 | MYO9B | up-regulates | hsa-mir-338 | represses | R-166 | 79 | 21 | Drugs (1) |
| CMF-42654 | MYO9B | up-regulates | hsa-mir-338 | represses | R-218 | 79 | 21 | Drugs (3) |
| CMF-42655 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2395 | 79 | 21 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-42656 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2431 | 79 | 21 | Drugs (2) |
| CMF-42657 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2459 | 79 | 21 | Drugs (3) |
| CMF-42658 | MYO9B | up-regulates | hsa-mir-338 | represses | R-651 | 79 | 21 | Drugs (2) |
| CMF-42659 | MYO9B | up-regulates | hsa-mir-338 | represses | R-655 | 79 | 21 | Drugs (3) |
| CMF-42660 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2710 | 79 | 21 | Drugs (1) |
| CMF-42661 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2760 | 79 | 21 | Drugs (3) |
| CMF-42662 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2830 | 79 | 21 | Drugs (2) |
| CMF-42663 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2864 | 79 | 21 | Drugs (2) |
| CMF-42664 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2892 | 79 | 21 | Drugs (3) |
| CMF-42665 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2940 | 79 | 21 | Drugs (2) |
| CMF-42666 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2950 | 79 | 21 | Drugs (3) |
| CMF-42667 | MYO9B | up-regulates | hsa-mir-338 | represses | R-3033 | 79 | 21 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42668 | MYO9B | up-regulates | hsa-mir-338 | represses | R-3180 | 79 | 21 | Drugs (1) |
| CMF-42669 | MYO9B | up-regulates | hsa-mir-338 | represses | R-1312 | 79 | 21 | Drugs (2) |
| CMF-42670 | MYO9B | up-regulates | hsa-mir-338 | represses | R-3643 | 79 | 21 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42671 | MYO9B | up-regulates | hsa-mir-338 | represses | R-2006 | 79 | 21 | Drugs (3) |