Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

JUN - Jun proto-oncogene, AP-1 transcription factor subunit

Function

Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
3725	ENSG00000177606	JUN	P05412

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000177606 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00329	COL6A3	up-regulates	JUN	activates	R-222	25	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-00330	COL6A3	up-regulates	JUN	activates	R-231	25	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-00331	COL6A3	up-regulates	JUN	activates	R-224	25	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-00332	COL6A3	up-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-00399	ZNF99	up-regulates	JUN	activates	R-213	25	1	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-00596	HMCN1	up-regulates	JUN	activates	R-222	25	14	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-00597	HMCN1	up-regulates	JUN	activates	R-218	25	14	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-00598	HMCN1	up-regulates	JUN	activates	R-209	25	14	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB
CMF-00599	HMCN1	up-regulates	JUN	activates	R-227	25	14	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN
CMF-00600	HMCN1	up-regulates	JUN	activates	R-226	25	14	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-00601	HMCN1	up-regulates	JUN	activates	R-217	25	14	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-00602	HMCN1	up-regulates	JUN	activates	R-231	25	14	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-00603	HMCN1	up-regulates	JUN	activates	R-212	25	14	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-00604	HMCN1	up-regulates	JUN	activates	R-214	25	14	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-00605	HMCN1	up-regulates	JUN	activates	R-213	25	14	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-00606	HMCN1	up-regulates	JUN	activates	R-224	25	14	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-00608	HMCN1	up-regulates	JUN	activates	R-216	25	14	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-00609	HMCN1	up-regulates	JUN	activates	R-211	25	14	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-01267	KRT37	up-regulates	JUN	activates	R-226	25	3	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-01268	KRT37	up-regulates	JUN	activates	R-212	25	3	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-01269	KRT37	up-regulates	JUN	activates	R-225	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01466	MTOR	up-regulates	JUN	activates	R-218	25	7	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-01467	MTOR	up-regulates	JUN	activates	R-226	25	7	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-01468	MTOR	up-regulates	JUN	activates	R-231	25	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-01469	MTOR	up-regulates	JUN	activates	R-214	25	7	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-01470	MTOR	up-regulates	JUN	activates	R-224	25	7	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-01471	MTOR	up-regulates	JUN	activates	R-216	25	7	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-02126	ABCA4	up-regulates	JUN	activates	R-231	25	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-03132	EEF1A1	up-regulates	JUN	activates	R-218	25	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-03440	ZNF28	down-regulates	JUN	activates	R-211	25	3	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-04750	ADAMTS20	up-regulates	JUN	activates	R-228	25	5	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-04751	ADAMTS20	up-regulates	JUN	activates	R-214	25	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-04752	ADAMTS20	up-regulates	JUN	activates	R-225	25	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04753	ADAMTS20	up-regulates	JUN	activates	R-224	25	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-05074	SPEG	down-regulates	JUN	activates	R-222	25	7	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-05075	SPEG	down-regulates	JUN	activates	R-217	25	7	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-05076	SPEG	down-regulates	JUN	activates	R-212	25	7	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-05079	SPEG	down-regulates	JUN	activates	R-215	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) SULTHIAME, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, BHQ-880
CMF-05288	PCSK6	up-regulates	JUN	activates	R-209	25	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB
CMF-05289	PCSK6	up-regulates	JUN	activates	R-217	25	6	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-05290	PCSK6	up-regulates	JUN	activates	R-225	25	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05888	FAM71B	down-regulates	JUN	activates	R-215	25	1	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) SULTHIAME, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, BHQ-880
CMF-08472	MSL3	down-regulates	JUN	activates	R-218	25	7	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-08473	MSL3	down-regulates	JUN	activates	R-217	25	7	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-08474	MSL3	down-regulates	JUN	activates	R-212	25	7	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-08476	MSL3	down-regulates	JUN	activates	R-216	25	7	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-08478	MSL3	down-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-09021	NALCN	down-regulates	JUN	activates	R-222	25	7	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-09023	NALCN	down-regulates	JUN	activates	R-231	25	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-09024	NALCN	down-regulates	JUN	activates	R-224	25	7	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-09025	NALCN	down-regulates	JUN	activates	R-215	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) SULTHIAME, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, BHQ-880
CMF-09027	NALCN	down-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-09425	ZIC4	up-regulates	JUN	activates	R-224	25	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-09426	ZIC4	up-regulates	JUN	activates	R-211	25	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-10462	MYOM2	up-regulates	JUN	activates	R-216	25	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-11106	ATF7IP2	up-regulates	JUN	activates	R-226	25	2	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-11516	OR2T6	down-regulates	JUN	activates	R-218	25	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-11839	SKIV2L	up-regulates	JUN	activates	R-207	25	3	Drugs (77) Regulator Drugs (0) Regulon Drugs (77) SARGRAMOSTIM, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, RUPATADINE, INTERFERON GAMMA-1B, SUNITINIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, AME-133V, ABATACEPT, L19IL2, AS-1409, PEXIDARTINIB HYDROCHLORIDE, PAZOPANIB HYDROCHLORIDE, CAFFEINE, CITRATED, MEDI-2338, VATALANIB, VOBARILIZUMAB, L19TNFA, EDICOTINIB, SUNITINIB MALATE, EFALIZUMAB, PLX-7486, TOCILIZUMAB, SOTRASTAURIN, DAPANSUTRILE, ENMD-2076, MUPARFOSTAT, CCX354, AMG-820, L19SIP 131I, UCN-01, TADEKINIG ALFA, PLX-5622, PF-04605412, SARILUMAB, NEIHULIZUMAB, AZD4818, BELATACEPT, SATRALIZUMAB, IC14, OTLERTUZUMAB, BI-836826, CAFFEINE, MAVRILIMUMAB, ERITORAN TETRASODIUM, ADENOSINE, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, DUPILUMAB, VELIFLAPON, BMS-817399, OCRIPLASMIN, ERITORAN, OXTRIPHYLLINE, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, IMC-CS4, NAMODENOSON, ARRY-382, EMACTUZUMAB, DELCASERTIB, LEVILIMAB, NARATUXIMAB EMTANSINE, GSK-690693, THEOPHYLLINE, AMG-557, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AXATILIMAB
CMF-11840	SKIV2L	up-regulates	JUN	activates	R-213	25	3	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-12495	LAMB3	up-regulates	JUN	activates	R-218	25	3	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-12925	HTR3E	down-regulates	JUN	activates	R-209	25	10	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB
CMF-12926	HTR3E	down-regulates	JUN	activates	R-228	25	10	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-12927	HTR3E	down-regulates	JUN	activates	R-217	25	10	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-12928	HTR3E	down-regulates	JUN	activates	R-212	25	10	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-12929	HTR3E	down-regulates	JUN	activates	R-214	25	10	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-12931	HTR3E	down-regulates	JUN	activates	R-224	25	10	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-12934	HTR3E	down-regulates	JUN	activates	R-211	25	10	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-13789	ADAMTS8	down-regulates	JUN	activates	R-222	25	7	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-13790	ADAMTS8	down-regulates	JUN	activates	R-207	25	7	Drugs (77) Regulator Drugs (0) Regulon Drugs (77) SARGRAMOSTIM, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, RUPATADINE, INTERFERON GAMMA-1B, SUNITINIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, AME-133V, ABATACEPT, L19IL2, AS-1409, PEXIDARTINIB HYDROCHLORIDE, PAZOPANIB HYDROCHLORIDE, CAFFEINE, CITRATED, MEDI-2338, VATALANIB, VOBARILIZUMAB, L19TNFA, EDICOTINIB, SUNITINIB MALATE, EFALIZUMAB, PLX-7486, TOCILIZUMAB, SOTRASTAURIN, DAPANSUTRILE, ENMD-2076, MUPARFOSTAT, CCX354, AMG-820, L19SIP 131I, UCN-01, TADEKINIG ALFA, PLX-5622, PF-04605412, SARILUMAB, NEIHULIZUMAB, AZD4818, BELATACEPT, SATRALIZUMAB, IC14, OTLERTUZUMAB, BI-836826, CAFFEINE, MAVRILIMUMAB, ERITORAN TETRASODIUM, ADENOSINE, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, DUPILUMAB, VELIFLAPON, BMS-817399, OCRIPLASMIN, ERITORAN, OXTRIPHYLLINE, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, IMC-CS4, NAMODENOSON, ARRY-382, EMACTUZUMAB, DELCASERTIB, LEVILIMAB, NARATUXIMAB EMTANSINE, GSK-690693, THEOPHYLLINE, AMG-557, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AXATILIMAB
CMF-13791	ADAMTS8	down-regulates	JUN	activates	R-218	25	7	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-13792	ADAMTS8	down-regulates	JUN	activates	R-228	25	7	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-13793	ADAMTS8	down-regulates	JUN	activates	R-213	25	7	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-13794	ADAMTS8	down-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-15645	DCHS2	up-regulates	JUN	activates	R-222	25	9	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-15647	DCHS2	up-regulates	JUN	activates	R-228	25	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-15648	DCHS2	up-regulates	JUN	activates	R-226	25	9	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-15649	DCHS2	up-regulates	JUN	activates	R-231	25	9	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-15650	DCHS2	up-regulates	JUN	activates	R-214	25	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-15651	DCHS2	up-regulates	JUN	activates	R-224	25	9	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-15653	DCHS2	up-regulates	JUN	activates	R-211	25	9	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-15795	GRM3	up-regulates	JUN	activates	R-211	25	1	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-16699	SI	up-regulates	JUN	activates	R-214	25	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-16700	SI	up-regulates	JUN	activates	R-224	25	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-16749	CPNE8	up-regulates	JUN	activates	R-207	25	4	Drugs (77) Regulator Drugs (0) Regulon Drugs (77) SARGRAMOSTIM, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, RUPATADINE, INTERFERON GAMMA-1B, SUNITINIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, AME-133V, ABATACEPT, L19IL2, AS-1409, PEXIDARTINIB HYDROCHLORIDE, PAZOPANIB HYDROCHLORIDE, CAFFEINE, CITRATED, MEDI-2338, VATALANIB, VOBARILIZUMAB, L19TNFA, EDICOTINIB, SUNITINIB MALATE, EFALIZUMAB, PLX-7486, TOCILIZUMAB, SOTRASTAURIN, DAPANSUTRILE, ENMD-2076, MUPARFOSTAT, CCX354, AMG-820, L19SIP 131I, UCN-01, TADEKINIG ALFA, PLX-5622, PF-04605412, SARILUMAB, NEIHULIZUMAB, AZD4818, BELATACEPT, SATRALIZUMAB, IC14, OTLERTUZUMAB, BI-836826, CAFFEINE, MAVRILIMUMAB, ERITORAN TETRASODIUM, ADENOSINE, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, DUPILUMAB, VELIFLAPON, BMS-817399, OCRIPLASMIN, ERITORAN, OXTRIPHYLLINE, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, IMC-CS4, NAMODENOSON, ARRY-382, EMACTUZUMAB, DELCASERTIB, LEVILIMAB, NARATUXIMAB EMTANSINE, GSK-690693, THEOPHYLLINE, AMG-557, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AXATILIMAB
CMF-16750	CPNE8	up-regulates	JUN	activates	R-228	25	4	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-16751	CPNE8	up-regulates	JUN	activates	R-213	25	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-16752	CPNE8	up-regulates	JUN	activates	R-225	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16847	OR5I1	down-regulates	JUN	activates	R-222	25	6	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-16848	OR5I1	down-regulates	JUN	activates	R-228	25	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-16849	OR5I1	down-regulates	JUN	activates	R-214	25	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-16851	OR5I1	down-regulates	JUN	activates	R-224	25	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-16919	TIE1	up-regulates	JUN	activates	R-217	25	3	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-16920	TIE1	up-regulates	JUN	activates	R-212	25	3	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-19348	NF1	up-regulates	JUN	activates	R-222	25	16	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-19350	NF1	up-regulates	JUN	activates	R-207	25	16	Drugs (77) Regulator Drugs (0) Regulon Drugs (77) SARGRAMOSTIM, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, RUPATADINE, INTERFERON GAMMA-1B, SUNITINIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, AME-133V, ABATACEPT, L19IL2, AS-1409, PEXIDARTINIB HYDROCHLORIDE, PAZOPANIB HYDROCHLORIDE, CAFFEINE, CITRATED, MEDI-2338, VATALANIB, VOBARILIZUMAB, L19TNFA, EDICOTINIB, SUNITINIB MALATE, EFALIZUMAB, PLX-7486, TOCILIZUMAB, SOTRASTAURIN, DAPANSUTRILE, ENMD-2076, MUPARFOSTAT, CCX354, AMG-820, L19SIP 131I, UCN-01, TADEKINIG ALFA, PLX-5622, PF-04605412, SARILUMAB, NEIHULIZUMAB, AZD4818, BELATACEPT, SATRALIZUMAB, IC14, OTLERTUZUMAB, BI-836826, CAFFEINE, MAVRILIMUMAB, ERITORAN TETRASODIUM, ADENOSINE, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, DUPILUMAB, VELIFLAPON, BMS-817399, OCRIPLASMIN, ERITORAN, OXTRIPHYLLINE, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, IMC-CS4, NAMODENOSON, ARRY-382, EMACTUZUMAB, DELCASERTIB, LEVILIMAB, NARATUXIMAB EMTANSINE, GSK-690693, THEOPHYLLINE, AMG-557, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AXATILIMAB
CMF-19351	NF1	up-regulates	JUN	activates	R-218	25	16	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-19352	NF1	up-regulates	JUN	activates	R-209	25	16	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB
CMF-19353	NF1	up-regulates	JUN	activates	R-226	25	16	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-19354	NF1	up-regulates	JUN	activates	R-217	25	16	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-19355	NF1	up-regulates	JUN	activates	R-231	25	16	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-19356	NF1	up-regulates	JUN	activates	R-212	25	16	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-19357	NF1	up-regulates	JUN	activates	R-213	25	16	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-19358	NF1	up-regulates	JUN	activates	R-224	25	16	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-19360	NF1	up-regulates	JUN	activates	R-216	25	16	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-19361	NF1	up-regulates	JUN	activates	R-215	25	16	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) SULTHIAME, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, BHQ-880
CMF-19362	NF1	up-regulates	JUN	activates	R-211	25	16	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-20268	ENAM	down-regulates	JUN	activates	R-222	25	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-20269	ENAM	down-regulates	JUN	activates	R-228	25	4	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-20270	ENAM	down-regulates	JUN	activates	R-216	25	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-20271	ENAM	down-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-20716	ALPK1	up-regulates	JUN	activates	R-218	25	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-20717	ALPK1	up-regulates	JUN	activates	R-212	25	4	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-20719	ALPK1	up-regulates	JUN	activates	R-216	25	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-22049	SPHKAP	down-regulates	JUN	activates	R-226	25	3	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-22050	SPHKAP	down-regulates	JUN	activates	R-212	25	3	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-23217	RNF17	up-regulates	JUN	activates	R-218	25	8	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-23218	RNF17	up-regulates	JUN	activates	R-209	25	8	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB
CMF-23219	RNF17	up-regulates	JUN	activates	R-226	25	8	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-23220	RNF17	up-regulates	JUN	activates	R-217	25	8	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-23221	RNF17	up-regulates	JUN	activates	R-212	25	8	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-23222	RNF17	up-regulates	JUN	activates	R-225	25	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23223	RNF17	up-regulates	JUN	activates	R-216	25	8	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-23224	RNF17	up-regulates	JUN	activates	R-211	25	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-23321	PABPC3	down-regulates	JUN	activates	R-227	25	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN
CMF-23322	PABPC3	down-regulates	JUN	activates	R-211	25	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-23358	DOCK2	up-regulates	JUN	activates	R-216	25	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-24157	HEATR5A	up-regulates	JUN	activates	R-226	25	4	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-24158	HEATR5A	up-regulates	JUN	activates	R-212	25	4	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-24159	HEATR5A	up-regulates	JUN	activates	R-225	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24160	HEATR5A	up-regulates	JUN	activates	R-216	25	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-25497	CCDC85A	down-regulates	JUN	activates	R-231	25	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-25498	CCDC85A	down-regulates	JUN	activates	R-216	25	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-26390	MAGEB1	down-regulates	JUN	activates	R-228	25	1	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-26791	ANK1	up-regulates	JUN	activates	R-231	25	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-26996	HMCN1	up-regulates	JUN	activates	R-216	25	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-26997	HMCN1	up-regulates	JUN	activates	R-211	25	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-27026	DNAH5	up-regulates	JUN	activates	R-226	25	4	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-27027	DNAH5	up-regulates	JUN	activates	R-212	25	4	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-27028	DNAH5	up-regulates	JUN	activates	R-214	25	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-27100	NBAS	up-regulates	JUN	activates	R-225	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27252	PDYN	up-regulates	JUN	activates	R-217	25	1	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-27508	KRTAP20-2	up-regulates	JUN	activates	R-207	25	6	Drugs (77) Regulator Drugs (0) Regulon Drugs (77) SARGRAMOSTIM, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, RUPATADINE, INTERFERON GAMMA-1B, SUNITINIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, AME-133V, ABATACEPT, L19IL2, AS-1409, PEXIDARTINIB HYDROCHLORIDE, PAZOPANIB HYDROCHLORIDE, CAFFEINE, CITRATED, MEDI-2338, VATALANIB, VOBARILIZUMAB, L19TNFA, EDICOTINIB, SUNITINIB MALATE, EFALIZUMAB, PLX-7486, TOCILIZUMAB, SOTRASTAURIN, DAPANSUTRILE, ENMD-2076, MUPARFOSTAT, CCX354, AMG-820, L19SIP 131I, UCN-01, TADEKINIG ALFA, PLX-5622, PF-04605412, SARILUMAB, NEIHULIZUMAB, AZD4818, BELATACEPT, SATRALIZUMAB, IC14, OTLERTUZUMAB, BI-836826, CAFFEINE, MAVRILIMUMAB, ERITORAN TETRASODIUM, ADENOSINE, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, DUPILUMAB, VELIFLAPON, BMS-817399, OCRIPLASMIN, ERITORAN, OXTRIPHYLLINE, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, IMC-CS4, NAMODENOSON, ARRY-382, EMACTUZUMAB, DELCASERTIB, LEVILIMAB, NARATUXIMAB EMTANSINE, GSK-690693, THEOPHYLLINE, AMG-557, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AXATILIMAB
CMF-27509	KRTAP20-2	up-regulates	JUN	activates	R-228	25	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-27510	KRTAP20-2	up-regulates	JUN	activates	R-213	25	6	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-27511	KRTAP20-2	up-regulates	JUN	activates	R-225	25	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27512	KRTAP20-2	up-regulates	JUN	activates	R-224	25	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-27784	CSMD3	down-regulates	JUN	activates	R-218	25	3	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-28069	CELSR3	down-regulates	JUN	activates	R-222	25	9	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN
CMF-28070	CELSR3	down-regulates	JUN	activates	R-218	25	9	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-28071	CELSR3	down-regulates	JUN	activates	R-209	25	9	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB
CMF-28072	CELSR3	down-regulates	JUN	activates	R-217	25	9	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-28073	CELSR3	down-regulates	JUN	activates	R-212	25	9	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-28074	CELSR3	down-regulates	JUN	activates	R-224	25	9	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-28075	CELSR3	down-regulates	JUN	activates	R-216	25	9	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-28077	CELSR3	down-regulates	JUN	activates	R-211	25	9	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-28688	SYNM	down-regulates	JUN	activates	R-212	25	3	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-28690	SYNM	down-regulates	JUN	activates	R-216	25	3	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-28763	MLL4	down-regulates	JUN	activates	R-218	25	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-28766	MLL4	down-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-29489	SEMA3E	up-regulates	JUN	activates	R-218	25	7	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-29490	SEMA3E	up-regulates	JUN	activates	R-231	25	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-29491	SEMA3E	up-regulates	JUN	activates	R-212	25	7	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-29492	SEMA3E	up-regulates	JUN	activates	R-216	25	7	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-29494	SEMA3E	up-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-29645	ESRRB	down-regulates	JUN	activates	R-218	25	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-29647	ESRRB	down-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-29866	ABCC9	up-regulates	JUN	activates	R-227	25	8	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN
CMF-29867	ABCC9	up-regulates	JUN	activates	R-231	25	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-29868	ABCC9	up-regulates	JUN	activates	R-214	25	8	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) SULTHIAME, TOSEDOSTAT, BIVATUZUMAB
CMF-29869	ABCC9	up-regulates	JUN	activates	R-224	25	8	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-29870	ABCC9	up-regulates	JUN	activates	R-216	25	8	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN
CMF-29871	ABCC9	up-regulates	JUN	activates	R-215	25	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) SULTHIAME, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, BHQ-880
CMF-29872	ABCC9	up-regulates	JUN	activates	R-211	25	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-30578	C17orf71	up-regulates	JUN	activates	R-217	25	2	Drugs (24) Regulator Drugs (0) Regulon Drugs (24) TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE
CMF-30579	C17orf71	up-regulates	JUN	activates	R-212	25	2	Drugs (62) Regulator Drugs (0) Regulon Drugs (62) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, GOLVATINIB
CMF-30622	SALL4	down-regulates	JUN	activates	R-207	25	9	Drugs (77) Regulator Drugs (0) Regulon Drugs (77) SARGRAMOSTIM, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, RUPATADINE, INTERFERON GAMMA-1B, SUNITINIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, AME-133V, ABATACEPT, L19IL2, AS-1409, PEXIDARTINIB HYDROCHLORIDE, PAZOPANIB HYDROCHLORIDE, CAFFEINE, CITRATED, MEDI-2338, VATALANIB, VOBARILIZUMAB, L19TNFA, EDICOTINIB, SUNITINIB MALATE, EFALIZUMAB, PLX-7486, TOCILIZUMAB, SOTRASTAURIN, DAPANSUTRILE, ENMD-2076, MUPARFOSTAT, CCX354, AMG-820, L19SIP 131I, UCN-01, TADEKINIG ALFA, PLX-5622, PF-04605412, SARILUMAB, NEIHULIZUMAB, AZD4818, BELATACEPT, SATRALIZUMAB, IC14, OTLERTUZUMAB, BI-836826, CAFFEINE, MAVRILIMUMAB, ERITORAN TETRASODIUM, ADENOSINE, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, DUPILUMAB, VELIFLAPON, BMS-817399, OCRIPLASMIN, ERITORAN, OXTRIPHYLLINE, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, IMC-CS4, NAMODENOSON, ARRY-382, EMACTUZUMAB, DELCASERTIB, LEVILIMAB, NARATUXIMAB EMTANSINE, GSK-690693, THEOPHYLLINE, AMG-557, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AXATILIMAB
CMF-30623	SALL4	down-regulates	JUN	activates	R-228	25	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE
CMF-30624	SALL4	down-regulates	JUN	activates	R-226	25	9	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-30625	SALL4	down-regulates	JUN	activates	R-213	25	9	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, ICATIBANT ACETATE, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LABRADIMIL, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, FASITIBANT, ICATIBANT, ZILTIVEKIMAB
CMF-30626	SALL4	down-regulates	JUN	activates	R-225	25	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30627	SALL4	down-regulates	JUN	activates	R-224	25	9	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-30629	SALL4	down-regulates	JUN	activates	R-216	25	9	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN

JUN - Jun proto-oncogene, AP-1 transcription factor subunit

Function

Causal Mechanistic Flows with ENSG00000177606 as Regulator

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Regulon Drugs (62)

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Regulon Drugs (7)