Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation MLL4_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-28758 | MLL4 | down-regulates | ERF | activates | R-3180 | 8 | 1 | Drugs (1) |
| CMF-28759 | MLL4 | down-regulates | EGR1 | activates | R-993 | 20 | 4 | Drugs (4) |
| CMF-28761 | MLL4 | down-regulates | EGR1 | activates | R-998 | 20 | 4 | Drugs (5) |
| CMF-28762 | MLL4 | down-regulates | EGR1 | activates | R-996 | 20 | 4 | Drugs (2) |
| CMF-28763 | MLL4 | down-regulates | JUN | activates | R-218 | 25 | 4 | Drugs (3) |
| CMF-28766 | MLL4 | down-regulates | JUN | activates | R-211 | 25 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB |
| CMF-28770 | MLL4 | down-regulates | STAT5A | activates | R-2950 | 21 | 7 | Drugs (3) |
| CMF-28771 | MLL4 | down-regulates | STAT5A | activates | R-2940 | 21 | 7 | Drugs (2) |
| CMF-28772 | MLL4 | down-regulates | STAT5A | activates | R-2944 | 21 | 7 | Drugs (5) |
| CMF-28774 | MLL4 | down-regulates | STAT5A | activates | R-2954 | 21 | 7 | Drugs (2) |
| CMF-28776 | MLL4 | down-regulates | TFCP2L1 | activates | R-2535 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28777 | MLL4 | down-regulates | IRF3 | activates | R-2438 | 25 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM |
| CMF-28778 | MLL4 | down-regulates | IRF3 | activates | R-2437 | 25 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28780 | MLL4 | down-regulates | IRF3 | activates | R-2427 | 25 | 5 | Drugs (1) |
| CMF-28781 | MLL4 | down-regulates | IRF3 | activates | R-2431 | 25 | 5 | Drugs (2) |
| CMF-28782 | MLL4 | down-regulates | FOS | activates | R-3397 | 6 | 2 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)ASP-3026, ALECTINIB, BRIGATINIB, LORLATINIB, ALECTINIB HYDROCHLORIDE, ENTRECTINIB, DANTROLENE, CRIZOTINIB, PLB1003, ENSARTINIB, DANTROLENE SODIUM, CEP-37440, CONTELTINIB, CERITINIB |
| CMF-28783 | MLL4 | down-regulates | FOS | activates | R-3401 | 6 | 2 | Drugs (1) |
| CMF-28784 | MLL4 | down-regulates | HMGA2 | activates | R-3604 | 2 | 1 | Drugs (1) |
| CMF-28786 | MLL4 | down-regulates | ELF4 | activates | R-3016 | 20 | 2 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-28788 | MLL4 | down-regulates | GLI3 | activates | R-3386 | 6 | 2 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)PAZOPANIB, PEMIGATINIB, BRIVANIB ALANINATE, ERDAFITINIB, HMPL-453, PAZOPANIB HYDROCHLORIDE, BRIVANIB, NINTEDANIB ESYLATE, XL-999, DOVITINIB, ROGARATINIB, AZD-4547, ENMD-2076, INFIGRATINIB, FGFR INHIBITOR DEBIO 1347, INFIGRATINIB PHOSPHATE, NINTEDANIB, FUTIBATINIB, MASITINIB, ORANTINIB, DERAZANTINIB, E-7090, ENMD-981693 |