Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CREB3L1 - cAMP responsive element binding protein 3 like 1
Function
(Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 90993 | ENSG00000157613 | CREB3L1 | Q96BA8 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000157613 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04957 | ABCC5 | down-regulates | CREB3L1 | activates | R-3094 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-07033 | ATRX | down-regulates | CREB3L1 | activates | R-3094 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-07034 | ATRX | down-regulates | CREB3L1 | activates | R-3095 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09169 | DSC2 | down-regulates | CREB3L1 | activates | R-3095 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11955 | CSMD1 | up-regulates | CREB3L1 | activates | R-3094 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-12949 | HTR3E | down-regulates | CREB3L1 | activates | R-3094 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20524 | BCL11A | down-regulates | CREB3L1 | activates | R-3095 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22780 | IDH1 | down-regulates | CREB3L1 | activates | R-3094 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-22781 | IDH1 | down-regulates | CREB3L1 | activates | R-3095 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23323 | PABPC3 | down-regulates | CREB3L1 | activates | R-3094 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-23969 | TP53 | down-regulates | CREB3L1 | activates | R-3094 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-24876 | NSUN5 | down-regulates | CREB3L1 | activates | R-3094 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-24877 | NSUN5 | down-regulates | CREB3L1 | activates | R-3095 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25608 | COL6A6 | down-regulates | CREB3L1 | activates | R-3095 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28430 | MYO9B | down-regulates | CREB3L1 | activates | R-3094 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |