Regulon

Regulon: R-3094

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
132.7649819Pr-137Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
3998 ENSG00000074695 LMAN1 P49257
64778 ENSG00000075420 FNDC3B Q53EP0
966 ENSG00000085063 CD59 P13987
10484 ENSG00000100934 SEC23A Q15436
5573 ENSG00000108946 PRKAR1A P10644
10312 ENSG00000110719 TCIRG1 Q13488
813 ENSG00000128595 CALU O43852
51303 ENSG00000134285 FKBP11 Q9NYL4
8763 ENSG00000135535 CD164 Q04900
56929 ENSG00000145780 FEM1C Q96JP0
476 ENSG00000163399 ATP1A1 P05023
7106 ENSG00000214063 TSPAN4 O14817
81567 ENSG00000239264 TXNDC5 Q8NBS9

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
LANATOSIDE CATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
DIGOXINATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
ACETYLDIGITOXINATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
DIGITOXINATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
DESLANOSIDEATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor40
ISTAROXIMEATP1A1Small moleculeINHIBITORSodium/potassium-transporting ATPase inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-3094

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-04957ABCC5down-regulatesCREB3L1activatesR-309421Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-07033ATRXdown-regulatesCREB3L1activatesR-309422Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-11955CSMD1up-regulatesCREB3L1activatesR-309421Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-12949HTR3Edown-regulatesCREB3L1activatesR-309421Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-22780IDH1down-regulatesCREB3L1activatesR-309422Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-23323PABPC3down-regulatesCREB3L1activatesR-309421Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-23969TP53down-regulatesCREB3L1activatesR-309421Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-24876NSUN5down-regulatesCREB3L1activatesR-309422Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME

CMF-28430MYO9Bdown-regulatesCREB3L1activatesR-309421Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME