Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PARP1 - poly(ADP-ribose) polymerase 1
Function
Poly [ADP-ribose] polymerase 1, processed N-terminusThis cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 142 | ENSG00000143799 | PARP1 | P09874 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000143799 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00841 | MUC2 | down-regulates | PARP1 | activates | R-2372 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00844 | MUC2 | down-regulates | PARP1 | activates | R-2374 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01755 | ATP2B2 | up-regulates | PARP1 | activates | R-2374 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02493 | DNAH9 | up-regulates | PARP1 | activates | R-2374 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02716 | ABCA5 | up-regulates | PARP1 | activates | R-2371 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03897 | DSP | up-regulates | PARP1 | activates | R-2372 | 11 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03900 | DSP | up-regulates | PARP1 | activates | R-2374 | 11 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05512 | IL18RAP | up-regulates | PARP1 | activates | R-2374 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07542 | ANO7 | down-regulates | PARP1 | activates | R-2371 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08534 | MYO3A | up-regulates | PARP1 | activates | R-2374 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09145 | RSBN1L | down-regulates | PARP1 | activates | R-2371 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10671 | ITIH5L | up-regulates | PARP1 | activates | R-2374 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11176 | DGKD | down-regulates | PARP1 | activates | R-2374 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13094 | CLYBL | up-regulates | PARP1 | activates | R-2371 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13517 | FMN1 | up-regulates | PARP1 | activates | R-2372 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13520 | FMN1 | up-regulates | PARP1 | activates | R-2374 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13698 | KEL | down-regulates | PARP1 | activates | R-2374 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14007 | PLEKHA5 | up-regulates | PARP1 | activates | R-2370 | 11 | 1 | Drugs (1) |
| CMF-14310 | STK31 | down-regulates | PARP1 | activates | R-2372 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15189 | ERCC6 | down-regulates | PARP1 | activates | R-2371 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16238 | USP11 | down-regulates | PARP1 | activates | R-2372 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22200 | TEK | down-regulates | PARP1 | activates | R-2374 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27932 | CXorf22 | up-regulates | PARP1 | activates | R-2372 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30001 | CYP4F3 | down-regulates | PARP1 | activates | R-2374 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30585 | C17orf71 | up-regulates | PARP1 | activates | R-2372 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31146 | LRFN2 | up-regulates | PARP1 | activates | R-2374 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |