Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ATF1 - activating transcription factor 1
Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 466 | ENSG00000123268 | ATF1 | P18846 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000123268 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04007 | DSP | up-regulates | ATF1 | activates | R-457 | 7 | 4 | Drugs (1) |
| CMF-17809 | ANO2 | down-regulates | ATF1 | activates | R-457 | 7 | 2 | Drugs (1) |
| CMF-18844 | SLFN13 | up-regulates | ATF1 | activates | R-457 | 7 | 1 | Drugs (1) |
| CMF-19571 | NF1 | up-regulates | ATF1 | activates | R-457 | 7 | 2 | Drugs (1) |
| CMF-21429 | GRIK3 | up-regulates | ATF1 | activates | R-457 | 7 | 1 | Drugs (1) |
| CMF-21723 | MUC17 | up-regulates | ATF1 | activates | R-457 | 7 | 3 | Drugs (1) |