Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SOX10 - SRY-box transcription factor 10

Function

Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6663 ENSG00000100146 SOX10 P56693

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000100146 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00559HMCN1down-regulatesSOX10repressesR-306385Drugs (33)
CMF-00561HMCN1down-regulatesSOX10repressesR-306685Drugs (4)
CMF-00562HMCN1down-regulatesSOX10repressesR-307085Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-00563HMCN1down-regulatesSOX10repressesR-306985Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-00776TTNdown-regulatesSOX10repressesR-307082Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-00777TTNdown-regulatesSOX10repressesR-306982Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-03124EEF1A1down-regulatesSOX10repressesR-306982Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05366KDELC2down-regulatesSOX10repressesR-307081Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-05682FAT2down-regulatesSOX10activatesR-306483Drugs (11)
CMF-07403THOC2down-regulatesSOX10repressesR-306383Drugs (33)
CMF-07405THOC2down-regulatesSOX10repressesR-306983Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07489MAGup-regulatesSOX10repressesR-307081Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-07982OR5D13down-regulatesSOX10repressesR-306383Drugs (33)
CMF-07984OR5D13down-regulatesSOX10repressesR-306983Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08527MYO3Aup-regulatesSOX10activatesR-306481Drugs (11)
CMF-08687MYH14down-regulatesSOX10repressesR-307082Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-11259OR5W2down-regulatesSOX10repressesR-306682Drugs (4)
CMF-12689PTPRDdown-regulatesSOX10repressesR-306681Drugs (4)
CMF-12961SCN11Adown-regulatesSOX10activatesR-306481Drugs (11)
CMF-14459ANKRD33down-regulatesSOX10activatesR-306481Drugs (11)
CMF-15384DSEdown-regulatesSOX10repressesR-306382Drugs (33)
CMF-16195USP11up-regulatesSOX10repressesR-306681Drugs (4)
CMF-16660DNAJC11down-regulatesSOX10repressesR-306982Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-16875ATAD2down-regulatesSOX10repressesR-306982Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17526CNTNAP3down-regulatesSOX10activatesR-306481Drugs (11)
CMF-17609ODZ1down-regulatesSOX10activatesR-306482Drugs (11)
CMF-17968PRPF40Bup-regulatesSOX10repressesR-306383Drugs (33)
CMF-17969PRPF40Bup-regulatesSOX10repressesR-306683Drugs (4)
CMF-17970PRPF40Bup-regulatesSOX10repressesR-307083Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-20947KLHL13down-regulatesSOX10repressesR-306981Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21331GRIK3down-regulatesSOX10repressesR-306383Drugs (33)
CMF-21333GRIK3down-regulatesSOX10repressesR-306983Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22036COL27A1up-regulatesSOX10activatesR-306481Drugs (11)
CMF-23726TP53up-regulatesSOX10repressesR-306387Drugs (33)
CMF-23728TP53up-regulatesSOX10activatesR-306487Drugs (11)
CMF-23729TP53up-regulatesSOX10repressesR-306687Drugs (4)
CMF-23730TP53up-regulatesSOX10repressesR-307087Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-23731TP53up-regulatesSOX10repressesR-306987Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25913MMP13down-regulatesSOX10activatesR-306481Drugs (11)
CMF-25951C10orf12up-regulatesSOX10repressesR-306382Drugs (33)
CMF-26545AADACL4up-regulatesSOX10repressesR-306381Drugs (33)
CMF-26628C5AR1down-regulatesSOX10repressesR-306381Drugs (33)
CMF-27594ANKRD36down-regulatesSOX10repressesR-306383Drugs (33)
CMF-27596ANKRD36down-regulatesSOX10repressesR-306983Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-27736FSTL5down-regulatesSOX10repressesR-307081Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB