Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation PDGFRA_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-22130PDGFRAdown-regulatesIRF2activatesR-431253Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

DANVATIRSEN

CMF-22131PDGFRAdown-regulatesIRF2activatesR-420253Drugs (6)
CMF-22133PDGFRAdown-regulatesESRRAactivatesR-1970194Drugs (7)

Regulator Drugs (0)

Regulon Drugs (7)

BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN

CMF-22137PDGFRAdown-regulatesSPI1activatesR-378259Drugs (7)
CMF-22138PDGFRAdown-regulatesSPI1activatesR-376259Drugs (88)
CMF-22145PDGFRAdown-regulatesSPI1activatesR-373259Drugs (47)
CMF-22147PDGFRAdown-regulatesFOXC1activatesR-646202Drugs (15)
CMF-22148PDGFRAdown-regulatesSTAT5AactivatesR-2949213Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, ALICAFORSEN

CMF-22149PDGFRAdown-regulatesSTAT5AactivatesR-2954213Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

ALEPLASININ, VESENCUMAB

CMF-22150PDGFRAdown-regulatesSTAT5AactivatesR-2955213Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

DANVATIRSEN

CMF-22151PDGFRAdown-regulatesGATA6activatesR-1256181Drugs (5)
CMF-22153PDGFRAdown-regulatesTFCP2L1activatesR-253532Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22154PDGFRAdown-regulatesIRF3activatesR-2449252Drugs (17)
CMF-22155PDGFRAdown-regulatesIRF3activatesR-2430252Drugs (6)
CMF-22156PDGFRAdown-regulatesNFE2L2activatesR-1381103Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22158PDGFRAdown-regulatesELF4activatesR-3010201Drugs (9)
CMF-22159PDGFRAdown-regulatesNR1H2activatesR-360642Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ANG1005

CMF-22161PDGFRAdown-regulatesVDRactivatesR-245144Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-22162PDGFRAdown-regulatesVDRactivatesR-240144Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

HCBE-11, AVDORALIMAB, AVACOPAN

CMF-22166PDGFRAdown-regulatesKLF4activatesR-2122107Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-22168PDGFRAdown-regulatesKLF4activatesR-2120107Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22169PDGFRAdown-regulatesKLF4activatesR-2116107Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22170PDGFRAdown-regulatesKLF4activatesR-2115107Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-22175PDGFRAdown-regulatesRUNX3activatesR-197112Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-22176PDGFRAdown-regulatesRUNX3activatesR-192112Drugs (56)
CMF-22177PDGFRAdown-regulatesELF3activatesR-3692141Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22180PDGFRAdown-regulatesNFATC4activatesR-2712104Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22182PDGFRAdown-regulatesNFATC4activatesR-2705104Drugs (7)
CMF-22183PDGFRAdown-regulatesNFATC4activatesR-2707104Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST

CMF-22184PDGFRAdown-regulatesSTAT6activatesR-2285114Drugs (59)
CMF-22186PDGFRAdown-regulatesSTAT6activatesR-2287114Drugs (6)
CMF-22187PDGFRAdown-regulatesSTAT6activatesR-2280114Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DANVATIRSEN, CARLUMAB

CMF-22190PDGFRAdown-regulatesFLI1activatesR-3267113Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

IMPLITAPIDE, PD-360324, MCS-110, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-22192PDGFRAdown-regulatesFLI1activatesR-3265113Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

RILOTUMUMAB, FICLATUZUMAB

CMF-40414PDGFRAup-regulateshsa-mir-219repressesR-3180411Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ANG1005

CMF-40415PDGFRAup-regulateshsa-mir-9repressesR-572257Drugs (11)
CMF-40416PDGFRAup-regulateshsa-mir-9repressesR-646257Drugs (15)
CMF-40417PDGFRAup-regulateshsa-mir-9repressesR-3010257Drugs (9)
CMF-40418PDGFRAup-regulateshsa-mir-9repressesR-467257Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-40419PDGFRAup-regulateshsa-mir-9repressesR-3138257Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-40420PDGFRAup-regulateshsa-mir-9repressesR-1168257Drugs (7)
CMF-40421PDGFRAup-regulateshsa-mir-9repressesR-3758257Drugs (7)