Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ELF3 - E74 like ETS transcription factor 3
Function
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1999 | ENSG00000163435 | ELF3 | P78545 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000163435 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01569 | CACNA1B | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-01654 | ZNF814 | down-regulates | ELF3 | activates | R-3684 | 14 | 1 | Drugs (4) |
| CMF-02922 | KCNU1 | down-regulates | ELF3 | activates | R-3695 | 14 | 1 | Drugs (2) |
| CMF-03197 | GCC2 | down-regulates | ELF3 | activates | R-3686 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04592 | LAMC3 | down-regulates | ELF3 | activates | R-3684 | 14 | 2 | Drugs (4) |
| CMF-05043 | NUP210L | down-regulates | ELF3 | activates | R-3695 | 14 | 2 | Drugs (2) |
| CMF-05149 | KCNH1 | up-regulates | ELF3 | activates | R-3686 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05826 | SYNE2 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-05949 | KIAA1244 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-06060 | OTOA | down-regulates | ELF3 | activates | R-3684 | 14 | 3 | Drugs (4) |
| CMF-06188 | MDGA2 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-07122 | ATRX | down-regulates | ELF3 | activates | R-3684 | 14 | 8 | Drugs (4) |
| CMF-07123 | ATRX | down-regulates | ELF3 | activates | R-3692 | 14 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07124 | ATRX | down-regulates | ELF3 | activates | R-3695 | 14 | 8 | Drugs (2) |
| CMF-07125 | ATRX | down-regulates | ELF3 | activates | R-3686 | 14 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07680 | SAMD9L | down-regulates | ELF3 | activates | R-3695 | 14 | 1 | Drugs (2) |
| CMF-07858 | TNK2 | down-regulates | ELF3 | activates | R-3686 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08234 | EPHA5 | down-regulates | ELF3 | represses | R-3690 | 14 | 2 | Drugs (1) |
| CMF-08542 | MYO3A | down-regulates | ELF3 | represses | R-3690 | 14 | 2 | Drugs (1) |
| CMF-09973 | FBN1 | down-regulates | ELF3 | activates | R-3684 | 14 | 1 | Drugs (4) |
| CMF-11583 | MYH15 | down-regulates | ELF3 | activates | R-3684 | 14 | 2 | Drugs (4) |
| CMF-11617 | DBR1 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-12192 | CELSR1 | down-regulates | ELF3 | represses | R-3690 | 14 | 4 | Drugs (1) |
| CMF-12567 | ADAMTS16 | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12955 | HTR3E | down-regulates | ELF3 | activates | R-3684 | 14 | 1 | Drugs (4) |
| CMF-13941 | HRH2 | up-regulates | ELF3 | activates | R-3695 | 14 | 4 | Drugs (2) |
| CMF-13942 | HRH2 | up-regulates | ELF3 | activates | R-3686 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14042 | CEACAM20 | down-regulates | ELF3 | represses | R-3683 | 14 | 3 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-14043 | CEACAM20 | down-regulates | ELF3 | activates | R-3695 | 14 | 3 | Drugs (2) |
| CMF-15041 | TG | down-regulates | ELF3 | represses | R-3683 | 14 | 3 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-15042 | TG | down-regulates | ELF3 | activates | R-3695 | 14 | 3 | Drugs (2) |
| CMF-15325 | GRM8 | down-regulates | ELF3 | represses | R-3683 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-16097 | NFIX | down-regulates | ELF3 | represses | R-3690 | 14 | 3 | Drugs (1) |
| CMF-17262 | MAP3K7 | down-regulates | ELF3 | activates | R-3692 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17438 | LGALS8 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-17571 | BRAF | down-regulates | ELF3 | represses | R-3683 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-17678 | DCAF8L2 | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18416 | FANCM | down-regulates | ELF3 | activates | R-3695 | 14 | 2 | Drugs (2) |
| CMF-18417 | FANCM | down-regulates | ELF3 | activates | R-3686 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18667 | CHRND | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18843 | SLFN13 | down-regulates | ELF3 | represses | R-3690 | 14 | 1 | Drugs (1) |
| CMF-20233 | GPR15 | up-regulates | ELF3 | activates | R-3684 | 14 | 1 | Drugs (4) |
| CMF-20462 | CUX2 | down-regulates | ELF3 | represses | R-3690 | 14 | 5 | Drugs (1) |
| CMF-21538 | KLHL34 | down-regulates | ELF3 | activates | R-3686 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21962 | FAT1 | down-regulates | ELF3 | represses | R-3683 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-21980 | MRGPRE | down-regulates | ELF3 | activates | R-3695 | 14 | 1 | Drugs (2) |
| CMF-22177 | PDGFRA | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22912 | IDH1 | down-regulates | ELF3 | activates | R-3684 | 14 | 9 | Drugs (4) |
| CMF-22914 | IDH1 | down-regulates | ELF3 | activates | R-3692 | 14 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22915 | IDH1 | down-regulates | ELF3 | activates | R-3695 | 14 | 9 | Drugs (2) |
| CMF-22916 | IDH1 | down-regulates | ELF3 | activates | R-3686 | 14 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23056 | AOX1 | down-regulates | ELF3 | activates | R-3692 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23284 | RNF17 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-24166 | HEATR5A | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-24838 | SULT1B1 | down-regulates | ELF3 | represses | R-3683 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-25085 | IQSEC3 | down-regulates | ELF3 | activates | R-3695 | 14 | 2 | Drugs (2) |
| CMF-25297 | PASD1 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-26706 | FBN2 | down-regulates | ELF3 | represses | R-3683 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-27716 | FAM83H | down-regulates | ELF3 | activates | R-3684 | 14 | 3 | Drugs (4) |
| CMF-27717 | FAM83H | down-regulates | ELF3 | activates | R-3695 | 14 | 3 | Drugs (2) |
| CMF-27718 | FAM83H | down-regulates | ELF3 | activates | R-3686 | 14 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28117 | CELSR3 | down-regulates | ELF3 | activates | R-3684 | 14 | 1 | Drugs (4) |
| CMF-28274 | ZIC1 | down-regulates | ELF3 | represses | R-3683 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-29082 | DNAH3 | down-regulates | ELF3 | represses | R-3683 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-29243 | AQP10 | down-regulates | ELF3 | activates | R-3686 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29378 | UHRF1BP1L | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30081 | FAM126B | down-regulates | ELF3 | represses | R-3683 | 14 | 3 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-30082 | FAM126B | down-regulates | ELF3 | represses | R-3690 | 14 | 3 | Drugs (1) |
| CMF-30778 | ZDBF2 | down-regulates | ELF3 | activates | R-3692 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30779 | ZDBF2 | down-regulates | ELF3 | activates | R-3695 | 14 | 2 | Drugs (2) |
| CMF-31058 | PNPLA7 | down-regulates | ELF3 | represses | R-3683 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |