Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

GATA6 - GATA binding protein 6

Function

Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341).

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
2627	ENSG00000141448	GATA6	Q92908

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000141448 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01745	ACAN	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-01963	PCDH9	down-regulates	GATA6	activates	R-1256	18	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02188	ANO1	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02211	PPL	down-regulates	GATA6	activates	R-1261	18	3	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-02225	KCNA10	down-regulates	GATA6	activates	R-1261	18	4	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-02227	KCNA10	down-regulates	GATA6	activates	R-1258	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02312	ERG	down-regulates	GATA6	represses	R-1248	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-02594	ROBO1	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02635	LBP	down-regulates	GATA6	represses	R-1248	18	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-02823	MST1	down-regulates	GATA6	represses	R-1253	18	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-03140	EEF1A1	down-regulates	GATA6	represses	R-1253	18	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-03142	EEF1A1	down-regulates	GATA6	represses	R-1248	18	3	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-03182	ZNF91	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-03403	CCDC60	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-03877	DSP	down-regulates	GATA6	represses	R-1253	18	10	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-03880	DSP	down-regulates	GATA6	represses	R-1248	18	10	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-04164	ESPNP	down-regulates	GATA6	represses	R-1248	18	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-04558	LAMC3	down-regulates	GATA6	activates	R-1256	18	8	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-04561	LAMC3	down-regulates	GATA6	activates	R-1258	18	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04856	NEFM	down-regulates	GATA6	represses	R-1248	18	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-05028	NUP210L	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-05029	NUP210L	down-regulates	GATA6	activates	R-1258	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05098	SPEG	down-regulates	GATA6	activates	R-1256	18	7	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-05304	PCSK6	down-regulates	GATA6	represses	R-1248	18	5	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-05305	PCSK6	down-regulates	GATA6	activates	R-1258	18	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05955	SLC9A4	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-05979	SIRPG	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-06209	HYDIN	down-regulates	GATA6	activates	R-1258	18	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06339	MATN4	down-regulates	GATA6	activates	R-1258	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07717	TRPM2	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-08112	PLEKHG4B	down-regulates	GATA6	activates	R-1256	18	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-08113	PLEKHG4B	down-regulates	GATA6	activates	R-1258	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08699	MYH14	down-regulates	GATA6	represses	R-1253	18	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-08798	FBLN2	down-regulates	GATA6	represses	R-1253	18	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-09093	TLL2	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-09158	RANBP6	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-09434	ZIC4	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-09516	DOCK11	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-10146	EML2	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-10232	SEMG1	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-10965	BMP5	down-regulates	GATA6	represses	R-1248	18	3	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-11317	RPTN	down-regulates	GATA6	represses	R-1248	18	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-11501	KIAA1324L	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-11844	SKIV2L	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-11888	PALM2-AKAP2	down-regulates	GATA6	represses	R-1253	18	4	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-11889	PALM2-AKAP2	down-regulates	GATA6	represses	R-1248	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-12648	REN	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-13696	KEL	down-regulates	GATA6	activates	R-1261	18	3	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-13820	ADAMTS8	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-14496	PRKCD	down-regulates	GATA6	activates	R-1258	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15151	YEATS2	down-regulates	GATA6	activates	R-1256	18	5	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-15153	YEATS2	down-regulates	GATA6	activates	R-1261	18	5	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-15287	HCN1	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-15319	GRM8	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-15417	DSE	down-regulates	GATA6	represses	R-1253	18	5	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-15668	DCHS2	down-regulates	GATA6	represses	R-1253	18	4	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-15669	DCHS2	down-regulates	GATA6	represses	R-1248	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-15737	FN1	down-regulates	GATA6	represses	R-1248	18	3	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-15895	TUBBP5	down-regulates	GATA6	represses	R-1248	18	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-15932	OR13C8	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-16064	NFIX	down-regulates	GATA6	represses	R-1248	18	3	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-16159	NLRP11	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-16233	USP11	down-regulates	GATA6	activates	R-1256	18	6	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-16235	USP11	down-regulates	GATA6	activates	R-1258	18	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16453	SUSD5	down-regulates	GATA6	represses	R-1248	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-17066	MAGEA6	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-17392	TBC1D8	down-regulates	GATA6	represses	R-1248	18	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-17489	DYNC1I1	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-17578	ITGAX	down-regulates	GATA6	activates	R-1258	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18302	MEGF8	down-regulates	GATA6	represses	R-1248	18	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-19820	OR6C75	down-regulates	GATA6	activates	R-1258	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20054	ARHGEF16	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-20671	CYP4B1	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-21146	ZNF208	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-21524	KLHL34	down-regulates	GATA6	activates	R-1258	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-21955	FAT1	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-21956	FAT1	down-regulates	GATA6	represses	R-1248	18	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-21973	MRGPRE	down-regulates	GATA6	activates	R-1258	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22151	PDGFRA	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-23377	KRTAP4-11	down-regulates	GATA6	activates	R-1258	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23395	FAM47C	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-25267	PASD1	down-regulates	GATA6	represses	R-1253	18	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-25404	CENPF	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-25596	LOC649330	down-regulates	GATA6	represses	R-1248	18	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, VARESPLADIB METHYL, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-25829	CD163	down-regulates	GATA6	activates	R-1258	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26042	PITX2	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-26216	CARD11	down-regulates	GATA6	activates	R-1261	18	3	Drugs (58) Regulator Drugs (0) Regulon Drugs (58) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-26217	CARD11	down-regulates	GATA6	activates	R-1258	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26265	CEP250	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-26396	MAGEB1	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-27701	FAM83H	down-regulates	GATA6	activates	R-1258	18	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27792	CSMD3	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28084	CELSR3	down-regulates	GATA6	activates	R-1256	18	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28423	MYO9B	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28624	ARHGAP28	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-29095	TUBB4Q	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-29351	RPL13AP6	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-29928	GABRA6	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30483	PROKR2	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-30684	ABCA13	down-regulates	GATA6	activates	R-1256	18	7	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30874	ARMC4	down-regulates	GATA6	represses	R-1253	18	1	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB
CMF-30901	NPY5R	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-31050	PNPLA7	down-regulates	GATA6	represses	R-1253	18	2	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB

GATA6 - GATA binding protein 6

Function

Causal Mechanistic Flows with ENSG00000141448 as Regulator

Regulator Drugs (0)

Regulon Drugs (5)

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Regulon Drugs (58)

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Regulon Drugs (58)

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Regulon Drugs (16)

Regulator Drugs (0)

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Regulator Drugs (0)

Regulon Drugs (16)

Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (16)

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Regulon Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (16)

Regulator Drugs (0)

Regulon Drugs (16)

Regulator Drugs (0)

Regulon Drugs (5)

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Regulon Drugs (0)

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Regulon Drugs (16)

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Regulon Drugs (5)

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Regulator Drugs (0)

Regulon Drugs (5)

Regulator Drugs (0)

Regulon Drugs (16)

Regulator Drugs (0)

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Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (9)

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Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (5)

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Regulon Drugs (5)

Regulator Drugs (0)

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Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (5)

Regulator Drugs (0)

Regulon Drugs (9)

Regulator Drugs (0)

Regulon Drugs (9)