Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation NALCN_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-09004 | NALCN | up-regulates | POU3F3 | represses | R-2622 | 19 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-09005 | NALCN | up-regulates | POU3F3 | represses | R-2620 | 19 | 2 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, CILENGITIDE, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB, ABITUZUMAB |
| CMF-09008 | NALCN | down-regulates | STAT3 | activates | R-1527 | 25 | 4 | Drugs (3) |
| CMF-09010 | NALCN | down-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-09011 | NALCN | down-regulates | ERF | activates | R-3180 | 8 | 1 | Drugs (1) |
| CMF-09012 | NALCN | down-regulates | RORA | activates | R-1949 | 8 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09014 | NALCN | up-regulates | SOX1 | represses | R-1831 | 20 | 2 | Drugs (2) |
| CMF-09015 | NALCN | up-regulates | SOX1 | represses | R-1847 | 20 | 2 | Drugs (2) |
| CMF-09016 | NALCN | up-regulates | PGR | represses | R-3404 | 8 | 1 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-09018 | NALCN | down-regulates | TEAD3 | activates | R-2105 | 15 | 4 | Drugs (2) |
| CMF-09021 | NALCN | down-regulates | JUN | activates | R-222 | 25 | 7 | Drugs (5) |
| CMF-09023 | NALCN | down-regulates | JUN | activates | R-231 | 25 | 7 | Drugs (2) |
| CMF-09024 | NALCN | down-regulates | JUN | activates | R-224 | 25 | 7 | Drugs (1) |
| CMF-09025 | NALCN | down-regulates | JUN | activates | R-215 | 25 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)SULTHIAME, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, BHQ-880 |
| CMF-09027 | NALCN | down-regulates | JUN | activates | R-211 | 25 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB |
| CMF-09028 | NALCN | down-regulates | HLX | activates | R-3580 | 10 | 2 | Drugs (3) |
| CMF-09029 | NALCN | down-regulates | HLX | activates | R-3582 | 10 | 2 | Drugs (4) |
| CMF-09034 | NALCN | down-regulates | NR2F6 | activates | R-2811 | 7 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DICHLORPHENAMIDE, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-09035 | NALCN | up-regulates | SOX21 | represses | R-3561 | 9 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09036 | NALCN | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-09037 | NALCN | down-regulates | CEBPB | activates | R-1305 | 23 | 4 | Drugs (5) |
| CMF-09038 | NALCN | down-regulates | CEBPB | activates | R-1314 | 23 | 4 | Drugs (1) |
| CMF-09039 | NALCN | down-regulates | CEBPB | activates | R-1312 | 23 | 4 | Drugs (2) |
| CMF-09040 | NALCN | down-regulates | CEBPB | activates | R-1306 | 23 | 4 | Drugs (1) |
| CMF-36382 | NALCN | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36383 | NALCN | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 11 | Drugs (2) |
| CMF-36384 | NALCN | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 11 | Drugs (2) |
| CMF-36385 | NALCN | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 11 | Drugs (2) |
| CMF-36386 | NALCN | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 11 | Drugs (2) |
| CMF-36387 | NALCN | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 11 | Drugs (2) |
| CMF-36388 | NALCN | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 11 | Drugs (2) |
| CMF-36389 | NALCN | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 11 | Drugs (2) |
| CMF-36390 | NALCN | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 11 | Drugs (2) |
| CMF-36391 | NALCN | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 11 | Drugs (2) |
| CMF-36392 | NALCN | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 11 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |