Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
HLX - H2.0 like homeobox
Function
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3142 | ENSG00000136630 | HLX | Q14774 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000136630 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00333 | COL6A3 | up-regulates | HLX | represses | R-3585 | 10 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00335 | COL6A3 | up-regulates | HLX | activates | R-3582 | 10 | 3 | Drugs (4) |
| CMF-01949 | PCDH9 | down-regulates | HLX | activates | R-3582 | 10 | 3 | Drugs (4) |
| CMF-02696 | UBE3C | down-regulates | HLX | activates | R-3580 | 10 | 1 | Drugs (3) |
| CMF-03512 | SCN1A | up-regulates | HLX | activates | R-3583 | 10 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03513 | SCN1A | up-regulates | HLX | activates | R-3588 | 10 | 2 | Drugs (1) |
| CMF-05771 | ADAMTS19 | down-regulates | HLX | activates | R-3582 | 10 | 1 | Drugs (4) |
| CMF-06337 | MATN4 | down-regulates | HLX | activates | R-3580 | 10 | 2 | Drugs (3) |
| CMF-08043 | ABCC4 | down-regulates | HLX | represses | R-3585 | 10 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08596 | FOXR2 | down-regulates | HLX | activates | R-3580 | 10 | 2 | Drugs (3) |
| CMF-08597 | FOXR2 | down-regulates | HLX | activates | R-3582 | 10 | 2 | Drugs (4) |
| CMF-09028 | NALCN | down-regulates | HLX | activates | R-3580 | 10 | 2 | Drugs (3) |
| CMF-09029 | NALCN | down-regulates | HLX | activates | R-3582 | 10 | 2 | Drugs (4) |
| CMF-09270 | RP1 | down-regulates | HLX | activates | R-3580 | 10 | 3 | Drugs (3) |
| CMF-09271 | RP1 | down-regulates | HLX | activates | R-3588 | 10 | 3 | Drugs (1) |
| CMF-09734 | MTF1 | down-regulates | HLX | activates | R-3583 | 10 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10231 | SEMG1 | down-regulates | HLX | activates | R-3582 | 10 | 3 | Drugs (4) |
| CMF-12294 | GPR98 | down-regulates | HLX | activates | R-3580 | 10 | 4 | Drugs (3) |
| CMF-12295 | GPR98 | down-regulates | HLX | activates | R-3582 | 10 | 4 | Drugs (4) |
| CMF-13795 | ADAMTS8 | down-regulates | HLX | represses | R-3585 | 10 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13796 | ADAMTS8 | down-regulates | HLX | activates | R-3580 | 10 | 3 | Drugs (3) |
| CMF-13797 | ADAMTS8 | down-regulates | HLX | activates | R-3582 | 10 | 3 | Drugs (4) |
| CMF-14723 | BCOR | down-regulates | HLX | represses | R-3585 | 10 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17387 | TBC1D8 | down-regulates | HLX | represses | R-3585 | 10 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17727 | PCDHB13 | up-regulates | HLX | activates | R-3583 | 10 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17728 | PCDHB13 | up-regulates | HLX | represses | R-3585 | 10 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19382 | NF1 | up-regulates | HLX | activates | R-3583 | 10 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19383 | NF1 | up-regulates | HLX | represses | R-3585 | 10 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19386 | NF1 | up-regulates | HLX | activates | R-3586 | 10 | 10 | Drugs (58) Regulator Drugs (0)Regulon Drugs (58)ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE |
| CMF-19388 | NF1 | up-regulates | HLX | activates | R-3580 | 10 | 10 | Drugs (3) |
| CMF-19389 | NF1 | up-regulates | HLX | activates | R-3588 | 10 | 10 | Drugs (1) |
| CMF-19391 | NF1 | up-regulates | HLX | activates | R-3582 | 10 | 10 | Drugs (4) |
| CMF-20217 | GPR15 | up-regulates | HLX | activates | R-3583 | 10 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20218 | GPR15 | up-regulates | HLX | represses | R-3585 | 10 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26260 | CEP250 | down-regulates | HLX | activates | R-3580 | 10 | 3 | Drugs (3) |
| CMF-26261 | CEP250 | down-regulates | HLX | activates | R-3582 | 10 | 3 | Drugs (4) |
| CMF-27233 | PCDH11X | down-regulates | HLX | activates | R-3580 | 10 | 1 | Drugs (3) |
| CMF-28404 | MYO9B | down-regulates | HLX | activates | R-3580 | 10 | 5 | Drugs (3) |
| CMF-28406 | MYO9B | down-regulates | HLX | activates | R-3582 | 10 | 5 | Drugs (4) |
| CMF-28548 | SNTG2 | down-regulates | HLX | activates | R-3586 | 10 | 1 | Drugs (58) Regulator Drugs (0)Regulon Drugs (58)ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE |
| CMF-30199 | OR4K13 | down-regulates | HLX | activates | R-3580 | 10 | 1 | Drugs (3) |
| CMF-30537 | JHDM1D | down-regulates | HLX | activates | R-3582 | 10 | 2 | Drugs (4) |