Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
hsa-mir-10b -
Function
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| - | hsa-mir-10b |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with hsa-mir-10b as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-33903 | TEX15 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 2 | Drugs (2) |
| CMF-33904 | TEX15 | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-34774 | ABCC5 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34775 | ABCC5 | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-34883 | ZFYVE26 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34884 | ZFYVE26 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36013 | AHNAK2 | up-regulates | hsa-mir-10b | represses | R-350 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)DASATINIB, VOBARILIZUMAB, BOSUTINIB, BAFETINIB, TOCILIZUMAB, ILORASERTIB, JNJ-26483327, SARILUMAB, XL-228, SATRALIZUMAB, IC14, TOLIMIDONE, ERITORAN TETRASODIUM, TG100-801, VB-201, ERITORAN, MILATUZUMAB, LEVILIMAB, AMG-557, ENMD-981693 |
| CMF-36110 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-171 | 14 | 12 | Drugs (2) |
| CMF-36111 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36112 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 12 | Drugs (2) |
| CMF-36113 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 12 | Drugs (2) |
| CMF-36114 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 12 | Drugs (2) |
| CMF-36115 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 12 | Drugs (2) |
| CMF-36116 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 12 | Drugs (2) |
| CMF-36117 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 12 | Drugs (2) |
| CMF-36118 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36119 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 12 | Drugs (2) |
| CMF-36120 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 12 | Drugs (2) |
| CMF-36121 | SAMD9L | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 12 | Drugs (2) |
| CMF-36382 | NALCN | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36383 | NALCN | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 11 | Drugs (2) |
| CMF-36384 | NALCN | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 11 | Drugs (2) |
| CMF-36385 | NALCN | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 11 | Drugs (2) |
| CMF-36386 | NALCN | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 11 | Drugs (2) |
| CMF-36387 | NALCN | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 11 | Drugs (2) |
| CMF-36388 | NALCN | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 11 | Drugs (2) |
| CMF-36389 | NALCN | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 11 | Drugs (2) |
| CMF-36390 | NALCN | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 11 | Drugs (2) |
| CMF-36391 | NALCN | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 11 | Drugs (2) |
| CMF-36392 | NALCN | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 11 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-36831 | NBEA | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36832 | NBEA | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37267 | DNAH17 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37268 | DNAH17 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 4 | Drugs (2) |
| CMF-37269 | DNAH17 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 4 | Drugs (2) |
| CMF-37270 | DNAH17 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 4 | Drugs (2) |
| CMF-37517 | HTR3E | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37518 | HTR3E | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38523 | USP11 | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-38607 | ADAMTS2 | down-regulates | hsa-mir-10b | represses | R-350 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)DASATINIB, VOBARILIZUMAB, BOSUTINIB, BAFETINIB, TOCILIZUMAB, ILORASERTIB, JNJ-26483327, SARILUMAB, XL-228, SATRALIZUMAB, IC14, TOLIMIDONE, ERITORAN TETRASODIUM, TG100-801, VB-201, ERITORAN, MILATUZUMAB, LEVILIMAB, AMG-557, ENMD-981693 |
| CMF-38642 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-171 | 14 | 12 | Drugs (2) |
| CMF-38643 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38644 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 12 | Drugs (2) |
| CMF-38645 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 12 | Drugs (2) |
| CMF-38646 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 12 | Drugs (2) |
| CMF-38647 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 12 | Drugs (2) |
| CMF-38648 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 12 | Drugs (2) |
| CMF-38649 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 12 | Drugs (2) |
| CMF-38650 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38651 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 12 | Drugs (2) |
| CMF-38652 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 12 | Drugs (2) |
| CMF-38653 | OR5I1 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 12 | Drugs (2) |
| CMF-38784 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38785 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 10 | Drugs (2) |
| CMF-38786 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 10 | Drugs (2) |
| CMF-38787 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 10 | Drugs (2) |
| CMF-38788 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 10 | Drugs (2) |
| CMF-38789 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 10 | Drugs (2) |
| CMF-38790 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 10 | Drugs (2) |
| CMF-38791 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 10 | Drugs (2) |
| CMF-38792 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 10 | Drugs (2) |
| CMF-38793 | A2BP1 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 10 | Drugs (2) |
| CMF-38854 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-171 | 14 | 12 | Drugs (2) |
| CMF-38855 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38856 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 12 | Drugs (2) |
| CMF-38857 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 12 | Drugs (2) |
| CMF-38858 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 12 | Drugs (2) |
| CMF-38859 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 12 | Drugs (2) |
| CMF-38860 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 12 | Drugs (2) |
| CMF-38861 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 12 | Drugs (2) |
| CMF-38862 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38863 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 12 | Drugs (2) |
| CMF-38864 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 12 | Drugs (2) |
| CMF-38865 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 12 | Drugs (2) |
| CMF-38923 | ANO2 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38924 | ANO2 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 9 | Drugs (2) |
| CMF-38925 | ANO2 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 9 | Drugs (2) |
| CMF-38926 | ANO2 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 9 | Drugs (2) |
| CMF-38927 | ANO2 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 9 | Drugs (2) |
| CMF-38928 | ANO2 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 9 | Drugs (2) |
| CMF-38929 | ANO2 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 9 | Drugs (2) |
| CMF-38930 | ANO2 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 9 | Drugs (2) |
| CMF-38931 | ANO2 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 9 | Drugs (2) |
| CMF-38973 | KCNH5 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-39318 | SLFN13 | down-regulates | hsa-mir-10b | represses | R-350 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)DASATINIB, VOBARILIZUMAB, BOSUTINIB, BAFETINIB, TOCILIZUMAB, ILORASERTIB, JNJ-26483327, SARILUMAB, XL-228, SATRALIZUMAB, IC14, TOLIMIDONE, ERITORAN TETRASODIUM, TG100-801, VB-201, ERITORAN, MILATUZUMAB, LEVILIMAB, AMG-557, ENMD-981693 |
| CMF-39661 | NF1 | down-regulates | hsa-mir-10b | represses | R-350 | 14 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)DASATINIB, VOBARILIZUMAB, BOSUTINIB, BAFETINIB, TOCILIZUMAB, ILORASERTIB, JNJ-26483327, SARILUMAB, XL-228, SATRALIZUMAB, IC14, TOLIMIDONE, ERITORAN TETRASODIUM, TG100-801, VB-201, ERITORAN, MILATUZUMAB, LEVILIMAB, AMG-557, ENMD-981693 |
| CMF-39662 | NF1 | down-regulates | hsa-mir-10b | represses | R-2053 | 14 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-40140 | STAB2 | up-regulates | hsa-mir-10b | represses | R-350 | 14 | 1 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)DASATINIB, VOBARILIZUMAB, BOSUTINIB, BAFETINIB, TOCILIZUMAB, ILORASERTIB, JNJ-26483327, SARILUMAB, XL-228, SATRALIZUMAB, IC14, TOLIMIDONE, ERITORAN TETRASODIUM, TG100-801, VB-201, ERITORAN, MILATUZUMAB, LEVILIMAB, AMG-557, ENMD-981693 |
| CMF-42049 | CD163 | up-regulates | hsa-mir-10b | represses | R-171 | 14 | 11 | Drugs (2) |
| CMF-42050 | CD163 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42051 | CD163 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 11 | Drugs (2) |
| CMF-42052 | CD163 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 11 | Drugs (2) |
| CMF-42053 | CD163 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 11 | Drugs (2) |
| CMF-42054 | CD163 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 11 | Drugs (2) |
| CMF-42055 | CD163 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 11 | Drugs (2) |
| CMF-42056 | CD163 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 11 | Drugs (2) |
| CMF-42057 | CD163 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 11 | Drugs (2) |
| CMF-42058 | CD163 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 11 | Drugs (2) |
| CMF-42059 | CD163 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 11 | Drugs (2) |
| CMF-42584 | ZIC1 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42585 | ZIC1 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 5 | Drugs (2) |
| CMF-42586 | ZIC1 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 5 | Drugs (2) |
| CMF-42587 | ZIC1 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 5 | Drugs (2) |
| CMF-42588 | ZIC1 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 5 | Drugs (2) |
| CMF-42612 | KRTAP4-8 | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-42672 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-171 | 14 | 11 | Drugs (2) |
| CMF-42673 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 11 | Drugs (2) |
| CMF-42674 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 11 | Drugs (2) |
| CMF-42675 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 11 | Drugs (2) |
| CMF-42676 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 11 | Drugs (2) |
| CMF-42677 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 11 | Drugs (2) |
| CMF-42678 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 11 | Drugs (2) |
| CMF-42679 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42680 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 11 | Drugs (2) |
| CMF-42681 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 11 | Drugs (2) |
| CMF-42682 | OR4A47 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 11 | Drugs (2) |
| CMF-42694 | IFT172 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 3 | Drugs (2) |
| CMF-42695 | IFT172 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42696 | IFT172 | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-42829 | ITGAM | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |