Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation LAMC3_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-04504LAMC3up-regulatesLHX2repressesR-370871Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

EMRICASAN

CMF-04505LAMC3down-regulatesNFKB1activatesR-297257Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

MIDOSTAURIN, DIPYRIDAMOLE, SOTRASTAURIN, UCN-01, DELCASERTIB, GSK-690693

CMF-04509LAMC3down-regulatesNFKB1activatesR-290257Drugs (110)
CMF-04510LAMC3down-regulatesNFKB1activatesR-299257Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-04512LAMC3up-regulatesSATB1activatesR-1693244Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04513LAMC3up-regulatesSATB1repressesR-1680244Drugs (7)
CMF-04516LAMC3up-regulatesSOX4repressesR-2053155Drugs (9)
CMF-04517LAMC3up-regulatesSOX4repressesR-2056155Drugs (23)
CMF-04520LAMC3up-regulatesSOX12activatesR-1105183Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04525LAMC3down-regulatesESRRAactivatesR-1970197Drugs (7)

Regulator Drugs (0)

Regulon Drugs (7)

BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN

CMF-04528LAMC3down-regulatesESRRAactivatesR-1968197Drugs (7)
CMF-04531LAMC3down-regulatesSPI1activatesR-378259Drugs (7)
CMF-04536LAMC3down-regulatesSPI1activatesR-370259Drugs (199)

Regulator Drugs (0)

Regulon Drugs (199)

PF-04691502, LY-2787106, FOSTAMATINIB DISODIUM, PICOTAMIDE, SARGRAMOSTIM, UMBRALISIB, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, BGT-226, SONOLISIB, RUPATADINE, CSL-324, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, BMS-986142, HM-71224, SUNITINIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, PEXIDARTINIB HYDROCHLORIDE, PF-06651600, AMY-101, LIPEGFILGRASTIM, ABIVERTINIB, VRC-01LS, PAZOPANIB HYDROCHLORIDE, ABIVERTINIB MALEATE, VICRIVIROC, MEDI-2338, VATALANIB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, CAROTUXIMAB, L19TNFA, EDICOTINIB, APLAVIROC, MARAVIROC, AZD-8848, SUNITINIB MALATE, EFALIZUMAB, DACTOLISIB, BOSUTINIB, BAFETINIB, FILGRASTIM, ZANDELISIB, HMPL-523, PLX-7486, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, RILZABRUTINIB, BALUGRASTIM, SPEBRUTINIB, SOTRASTAURIN, PILARALISIB, ILORASERTIB, DAPANSUTRILE, ENMD-2076, RO-5458640, CCX354, PREXIGEBERSEN, AMG-820, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, IBRUTINIB, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, PLX-5622, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, ENTOLIMOD, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, AZD4818, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, EVOBRUTINIB, CPG-52852, R-333, IMIQUIMOD, IC14, OTLERTUZUMAB, GUSACITINIB, BI-836826, TOLIMIDONE, MAVRILIMUMAB, TREGALIZUMAB, ERITORAN TETRASODIUM, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, SPEBRUTINIB BESYLATE, PEGCETACOPLAN, VICRIVIROC MALEATE, LENOGRASTIM, POSELTINIB, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, ACALISIB, PF-232798, ZANOLIMUMAB, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, PIRTOBRUTINIB, TELRATOLIMOD, AZD5672, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, FOSTAMATINIB, ELSUBRUTINIB, IMC-CS4, BRANEBRUTINIB, LENIOLISIB, OZAGREL, PA-799, ARRY-382, EMACTUZUMAB, LINTUZUMAB, TIRABRUTINIB, DELCASERTIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, GSK-690693, SF-1126, ORELABRUTINIB, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AL-78898A, ENMD-981693, PANULISIB, AXATILIMAB

CMF-04538LAMC3down-regulatesSPI1activatesR-385259Drugs (8)
CMF-04541LAMC3down-regulatesTAL1activatesR-315113Drugs (158)

Regulator Drugs (0)

Regulon Drugs (158)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, PAZOPANIB, MIDOSTAURIN, ATN-161, BGT-226, SONOLISIB, RUPATADINE, CSL-324, TERBOGREL, PARSACLISIB, ONERCEPT, R-343, VOXTALISIB, SUNITINIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, DASATINIB, DS-7423, GSK-2269557, ABATACEPT, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, PEXIDARTINIB HYDROCHLORIDE, LIPEGFILGRASTIM, PEGSUNERCEPT, PAZOPANIB HYDROCHLORIDE, GOLIMUMAB, VICRIVIROC, VATALANIB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, EDICOTINIB, APLAVIROC, MARAVIROC, SUNITINIB MALATE, DACTOLISIB, FILGRASTIM, ZANDELISIB, HMPL-523, PLX-7486, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, BALUGRASTIM, AFELIMOMAB, SOTRASTAURIN, OZORALIZUMAB, PILARALISIB, ILORASERTIB, CERTOLIZUMAB PEGOL, ENMD-2076, RO-5458640, MUPARFOSTAT, CCX354, PREXIGEBERSEN, AMG-820, TASELISIB, L19SIP 131I, AMG-319, UCN-01, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, PLX-5622, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, GEMTUZUMAB, ENTOLIMOD, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, AZD4818, BELATACEPT, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, R-333, OTLERTUZUMAB, GUSACITINIB, REMTOLUMAB, BI-836826, ERITORAN TETRASODIUM, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, VICRIVIROC MALEATE, LENOGRASTIM, PEXIDARTINIB, QUIZARTINIB, DUPILUMAB, ACALISIB, PF-232798, MIVAVOTINIB CITRATE, BMS-817399, AZD5672, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, FOSTAMATINIB, IMC-CS4, LENIOLISIB, OZAGREL, PA-799, ARRY-382, EMACTUZUMAB, PLACULUMAB, LINTUZUMAB, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, GSK-690693, SF-1126, CABIRALIZUMAB, ENMD-981693, PANULISIB, AXATILIMAB, NELFINAVIR

CMF-04544LAMC3down-regulatesIRF5activatesR-1089113Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

NANGIBOTIDE, ENILURACIL, GIMERACIL

CMF-04548LAMC3up-regulatesHOXC4activatesR-333971Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04550LAMC3down-regulatesSTAT5AactivatesR-2940216Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-04551LAMC3down-regulatesSTAT5AactivatesR-2954216Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

ALEPLASININ, VESENCUMAB

CMF-04552LAMC3down-regulatesSTAT5AactivatesR-2955216Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

DANVATIRSEN

CMF-04558LAMC3down-regulatesGATA6activatesR-1256188Drugs (5)
CMF-04561LAMC3down-regulatesGATA6activatesR-1258188Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04565LAMC3down-regulatesTFCP2L1activatesR-253631Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04566LAMC3down-regulatesIKZF1activatesR-3137165Drugs (7)

Regulator Drugs (0)

Regulon Drugs (7)

BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN

CMF-04567LAMC3down-regulatesIKZF1activatesR-3135165Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-04568LAMC3down-regulatesIKZF1activatesR-3140165Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04570LAMC3down-regulatesIKZF1activatesR-3138165Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-04571LAMC3down-regulatesIRF3activatesR-2446253Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BIVATUZUMAB

CMF-04572LAMC3down-regulatesIRF3activatesR-2449253Drugs (17)
CMF-04573LAMC3down-regulatesIRF3activatesR-2430253Drugs (6)
CMF-04574LAMC3down-regulatesPRDM1activatesR-153217Drugs (17)
CMF-04575LAMC3down-regulatesPRDM1activatesR-141217Drugs (7)
CMF-04576LAMC3down-regulatesPRDM1activatesR-137217Drugs (144)

Regulator Drugs (0)

Regulon Drugs (144)

PF-04691502, FOSTAMATINIB DISODIUM, UMBRALISIB, MIDOSTAURIN, ATN-161, BGT-226, SONOLISIB, CSL-324, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, BMS-986142, HM-71224, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, R-348, PF-06651600, LIPEGFILGRASTIM, ABIVERTINIB, VRC-01LS, ABIVERTINIB MALEATE, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, EFALIZUMAB, DACTOLISIB, BOSUTINIB, BAFETINIB, FILGRASTIM, ZANDELISIB, HMPL-523, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, RILZABRUTINIB, BALUGRASTIM, SPEBRUTINIB, SOTRASTAURIN, PILARALISIB, ILORASERTIB, DAPANSUTRILE, RO-5458640, MUPARFOSTAT, CCX354, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, IBRUTINIB, TADEKINIG ALFA, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, ENTOLIMOD, IDELALISIB, AZD4818, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, EVOBRUTINIB, SELGANTOLIMOD, R-333, IC14, OTLERTUZUMAB, GUSACITINIB, BI-836826, TOLIMIDONE, MOTOLIMOD, TREGALIZUMAB, ERITORAN TETRASODIUM, TG100-801, SPEBRUTINIB BESYLATE, LENOGRASTIM, POSELTINIB, LIFITEGRAST, VB-201, ACALISIB, ZANOLIMUMAB, MIVAVOTINIB CITRATE, BMS-817399, PIRTOBRUTINIB, TELRATOLIMOD, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, MILATUZUMAB, VOLOCIXIMAB, FOSTAMATINIB, TOMARALIMAB, ELSUBRUTINIB, BRANEBRUTINIB, LENIOLISIB, PA-799, TIRABRUTINIB, DELCASERTIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, GSK-690693, AMG-557, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB

CMF-04578LAMC3down-regulatesPRDM1activatesR-145217Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ABRILUMAB, MAGROLIMAB, NATALIZUMAB, FIRATEGRAST, VEDOLIZUMAB

CMF-04580LAMC3down-regulatesPRDM1activatesR-150217Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

DANVATIRSEN

CMF-04581LAMC3down-regulatesNR1H2activatesR-360641Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ANG1005

CMF-04582LAMC3down-regulatesVDRactivatesR-232145Drugs (60)
CMF-04584LAMC3down-regulatesVDRactivatesR-240145Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

HCBE-11, AVDORALIMAB, AVACOPAN

CMF-04587LAMC3up-regulatesSOX11repressesR-856192Drugs (7)
CMF-04589LAMC3up-regulatesMYCNrepressesR-180652Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NIVOCASAN, EMRICASAN

CMF-04592LAMC3down-regulatesELF3activatesR-3684142Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL

CMF-04597LAMC3down-regulatesNFATC4activatesR-2712103Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04599LAMC3down-regulatesNFATC4activatesR-2707103Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST

CMF-04601LAMC3down-regulatesSTAT6activatesR-2279114Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-04602LAMC3down-regulatesSTAT6activatesR-2285114Drugs (59)
CMF-04603LAMC3down-regulatesSTAT6activatesR-2287114Drugs (6)
CMF-04604LAMC3down-regulatesSTAT6activatesR-2280114Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DANVATIRSEN, CARLUMAB

CMF-04607LAMC3up-regulatesNKX2-2repressesR-3293176Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

BI-505, OBATOCLAX MESYLATE, OBATOCLAX, ALICAFORSEN

CMF-04611LAMC3down-regulatesFLI1activatesR-3267114Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

IMPLITAPIDE, PD-360324, MCS-110, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-04612LAMC3down-regulatesFLI1activatesR-3264114Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

ALEPLASININ, OCRIPLASMIN, VESENCUMAB

CMF-04613LAMC3down-regulatesFLI1activatesR-3265114Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

RILOTUMUMAB, FICLATUZUMAB

CMF-34697LAMC3down-regulateshsa-mir-150repressesR-201611Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-34698LAMC3up-regulateshsa-mir-130brepressesR-24693Drugs (63)
CMF-34699LAMC3up-regulateshsa-mir-130brepressesR-29093Drugs (110)
CMF-34700LAMC3up-regulateshsa-mir-130brepressesR-35693Drugs (108)