Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation FPR2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-19839 | FPR2 | down-regulates | PPARG | activates | R-2331 | 15 | 1 | Drugs (2) |
| CMF-19847 | FPR2 | up-regulates | HOXA7 | activates | R-3762 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-39858 | FPR2 | up-regulates | hsa-mir-454-3p | represses | R-2123 | 31 | 6 | Drugs (1) |
| CMF-39859 | FPR2 | up-regulates | hsa-mir-454-3p | represses | R-419 | 31 | 6 | Drugs (2) |
| CMF-39860 | FPR2 | up-regulates | hsa-mir-454-3p | represses | R-2767 | 31 | 6 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-39861 | FPR2 | up-regulates | hsa-mir-454-3p | represses | R-2885 | 31 | 6 | Drugs (1) |
| CMF-39862 | FPR2 | up-regulates | hsa-mir-454-3p | represses | R-3134 | 31 | 6 | Drugs (1) |
| CMF-39863 | FPR2 | up-regulates | hsa-mir-454-3p | represses | R-1679 | 31 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-39864 | FPR2 | up-regulates | hsa-mir-149 | represses | R-2123 | 51 | 5 | Drugs (1) |
| CMF-39865 | FPR2 | up-regulates | hsa-mir-149 | represses | R-419 | 51 | 5 | Drugs (2) |
| CMF-39866 | FPR2 | up-regulates | hsa-mir-149 | represses | R-2767 | 51 | 5 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-39867 | FPR2 | up-regulates | hsa-mir-149 | represses | R-2885 | 51 | 5 | Drugs (1) |
| CMF-39868 | FPR2 | up-regulates | hsa-mir-149 | represses | R-3134 | 51 | 5 | Drugs (1) |