Regulon

Regulon: R-2767

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
182.1925170Pr-4Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
2896 ENSG00000030582 GRN P28799
55843 ENSG00000075884 ARHGAP15 Q53QZ3
1075 ENSG00000109861 CTSC P53634
7421 ENSG00000111424 VDR F1D8P8
5777 ENSG00000111679 PTPN6 P29350
8673 ENSG00000118640 VAMP8 Q9BV40
59342 ENSG00000121064 SCPEP1 I3L2N6
5880 ENSG00000128340 RAC2 P15153
10095 ENSG00000130429 ARPC1B O15143
26578 ENSG00000134996 OSTF1 Q92882
9056 ENSG00000155465 SLC7A7 Q9UM01
10538 ENSG00000156127 BATF Q16520
5603 ENSG00000156711 MAPK13 A0A024RD04
56833 ENSG00000158714 SLAMF8 Q9P0V8
1508 ENSG00000164733 CTSB E9PSG5
2203 ENSG00000165140 FBP1 P09467
10437 ENSG00000216490 IFI30 P13284
240 ENSG00000275565 ALOX5 P09917

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
CALCIFEDIOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
BECOCALCIDIOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
PARICALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
INECALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
ERGOCALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist40
CHOLECALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist41
DOXERCALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist40
CALCITRIOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
BRENSOCATIBCTSCSmall moleculeINHIBITORDipeptidyl peptidase I inhibitor30
ELDECALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
CALCIPOTRIENEVDRSmall moleculeAGONISTVitamin D receptor agonist40
SEOCALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
PEFCALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
LUNACALCIPOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
DP001VDRSmall moleculeAGONISTVitamin D receptor agonist20
ALFACALCIDOLVDRSmall moleculeAGONISTVitamin D receptor agonist40

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2767

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01923PCDH9up-regulatesNR2F1repressesR-2767154Drugs (16)
CMF-18147NWD1down-regulatesNR2F1repressesR-2767151Drugs (16)
CMF-24187OR4K5up-regulatesNR2F1repressesR-2767151Drugs (16)
CMF-31072LRFN2up-regulatesNR2F1repressesR-2767155Drugs (16)
CMF-34017MCM6down-regulateshsa-mir-129repressesR-276715576Drugs (16)
CMF-34179ANO1up-regulateshsa-mir-454-3prepressesR-2767311Drugs (16)
CMF-34180ANO1up-regulateshsa-mir-488repressesR-2767191Drugs (16)
CMF-34407WDR90up-regulateshsa-mir-93repressesR-27674416Drugs (16)
CMF-34984SIRPGdown-regulateshsa-mir-346repressesR-27672018Drugs (16)
CMF-35033FGFR3down-regulateshsa-mir-346repressesR-27672016Drugs (16)
CMF-35059FGFR3down-regulateshsa-mir-454-3prepressesR-27673129Drugs (16)
CMF-35091FGFR3down-regulateshsa-mir-20brepressesR-27674426Drugs (16)
CMF-35278ATRXup-regulateshsa-mir-454-3prepressesR-27673122Drugs (16)
CMF-35501ATRXup-regulateshsa-mir-17-3prepressesR-27675231Drugs (16)
CMF-35534ATRXup-regulateshsa-mir-93repressesR-27674435Drugs (16)
CMF-35721ATRXup-regulateshsa-mir-20brepressesR-27674435Drugs (16)
CMF-36003AHNAK2up-regulateshsa-mir-93repressesR-27674426Drugs (16)
CMF-36031AHNAK2up-regulateshsa-mir-20brepressesR-27674426Drugs (16)
CMF-36164TNK2up-regulateshsa-mir-17-3prepressesR-27675240Drugs (16)
CMF-36697ATP8A2up-regulateshsa-mir-454-3prepressesR-27673127Drugs (16)
CMF-36740ATP8A2up-regulateshsa-mir-17-3prepressesR-27675240Drugs (16)
CMF-36769ATP8A2up-regulateshsa-mir-93repressesR-27674432Drugs (16)
CMF-36803ATP8A2up-regulateshsa-mir-20brepressesR-27674431Drugs (16)
CMF-37209CYP4F22down-regulateshsa-mir-129repressesR-276715535Drugs (16)
CMF-37707ADAMTS8up-regulateshsa-mir-17-3prepressesR-27675240Drugs (16)
CMF-37805ANKRD33down-regulateshsa-mir-488repressesR-2767196Drugs (16)
CMF-37827ANKRD33down-regulateshsa-mir-93repressesR-27674425Drugs (16)
CMF-38013PPEF2down-regulateshsa-mir-346repressesR-27672016Drugs (16)
CMF-38117OR51F1up-regulateshsa-mir-93repressesR-27674435Drugs (16)
CMF-38330ZNF845up-regulateshsa-mir-454-3prepressesR-27673127Drugs (16)
CMF-38460KCNB2down-regulateshsa-mir-17-3prepressesR-27675236Drugs (16)
CMF-38487KCNB2down-regulateshsa-mir-93repressesR-27674427Drugs (16)
CMF-38504NFIXdown-regulateshsa-mir-346repressesR-27672017Drugs (16)
CMF-38995SGIP1down-regulateshsa-mir-17-3prepressesR-27675226Drugs (16)
CMF-39019SGIP1down-regulateshsa-mir-93repressesR-27674423Drugs (16)
CMF-39042SGIP1down-regulateshsa-mir-20brepressesR-27674423Drugs (16)
CMF-39094MEGF8down-regulateshsa-mir-93repressesR-2767444Drugs (16)
CMF-39325INPP5Jup-regulateshsa-mir-488repressesR-27671910Drugs (16)
CMF-39351UPF1down-regulateshsa-mir-346repressesR-27672016Drugs (16)
CMF-39536NF1down-regulateshsa-mir-488repressesR-27671912Drugs (16)
CMF-39636NF1down-regulateshsa-mir-93repressesR-27674431Drugs (16)
CMF-39727NF1down-regulateshsa-mir-20brepressesR-27674431Drugs (16)
CMF-39782RPSAP58down-regulateshsa-mir-17-3prepressesR-27675240Drugs (16)
CMF-39860FPR2up-regulateshsa-mir-454-3prepressesR-2767316Drugs (16)
CMF-39866FPR2up-regulateshsa-mir-149repressesR-2767515Drugs (16)
CMF-39974TDRD9down-regulateshsa-mir-17-3prepressesR-27675242Drugs (16)
CMF-40005THSD7Bup-regulateshsa-mir-454-3prepressesR-2767315Drugs (16)
CMF-40010THSD7Bup-regulateshsa-mir-149repressesR-2767515Drugs (16)
CMF-40433IDH1up-regulateshsa-mir-346repressesR-27672020Drugs (16)
CMF-40522IDH1up-regulateshsa-mir-454-3prepressesR-27673122Drugs (16)
CMF-40652IDH1up-regulateshsa-mir-488repressesR-27671914Drugs (16)
CMF-40789IDH1up-regulateshsa-mir-17-3prepressesR-27675231Drugs (16)
CMF-40824IDH1up-regulateshsa-mir-93repressesR-27674435Drugs (16)
CMF-41011IDH1up-regulateshsa-mir-20brepressesR-27674435Drugs (16)
CMF-41231TP53up-regulateshsa-mir-346repressesR-27672020Drugs (16)
CMF-41351TP53up-regulateshsa-mir-17-3prepressesR-27675252Drugs (16)
CMF-41393TP53up-regulateshsa-mir-93repressesR-27674444Drugs (16)
CMF-41555TP53up-regulateshsa-mir-20brepressesR-27674444Drugs (16)
CMF-41576WBSCR17down-regulateshsa-mir-17-3prepressesR-27675212Drugs (16)
CMF-41782IQSEC3up-regulateshsa-mir-454-3prepressesR-27673125Drugs (16)
CMF-41916IQSEC3up-regulateshsa-mir-20brepressesR-27674434Drugs (16)
CMF-42020CD163up-regulateshsa-mir-149repressesR-27675116Drugs (16)
CMF-42151NAALADL1down-regulateshsa-mir-346repressesR-27672018Drugs (16)
CMF-42471FSTL5down-regulateshsa-mir-17-3prepressesR-27675216Drugs (16)
CMF-42762AQP10up-regulateshsa-mir-129repressesR-276715541Drugs (16)
CMF-42967ESRRBdown-regulateshsa-mir-454-3prepressesR-27673115Drugs (16)
CMF-42987ESRRBdown-regulateshsa-mir-488repressesR-2767194Drugs (16)
CMF-43006ESRRBdown-regulateshsa-mir-17-3prepressesR-27675228Drugs (16)
CMF-43046ESRRBdown-regulateshsa-mir-20brepressesR-27674428Drugs (16)
CMF-43190PRKDCdown-regulateshsa-mir-346repressesR-27672016Drugs (16)